APOBEC3D (apolipoprotein B mRNA editing enzyme catalytic subunit 3D)

2014-11-01  

Identity

HGNC
APOBEC3D
LOCATION
22q13.1
LOCUSID
140564
ALIAS
A3D,A3DE,APOBEC3DE,APOBEC3E,ARP6

Other Information

Locus ID:

NCBI: 140564
MIM: 609900
HGNC: 17354
Ensembl: ENSG00000243811

Variants:

dbSNP: 140564
ClinVar: 140564
TCGA: ENSG00000243811
COSMIC: APOBEC3D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000243811ENST00000216099Q96AK3
ENSG00000243811ENST00000216099B2CML4
ENSG00000243811ENST00000427494Q6ICH2
ENSG00000243811ENST00000622217A0A087WX48

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
228076802012Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n.67
230974382013APOBEC3G restricts HIV-1 to a greater extent than APOBEC3F and APOBEC3DE in human primary CD4+ T cells and macrophages.59
190888512008Distinct determinants in HIV-1 Vif and human APOBEC3 proteins are required for the suppression of diverse host anti-viral proteins.39
253301462014APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.39
242278422014APOBEC3 deaminases induce hypermutation in human papillomavirus 16 DNA upon beta interferon stimulation.25
237559662013Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations.20
274397152016APOBEC3 proteins can copackage and comutate HIV-1 genomes.11
274283322016APOBEC3DE Inhibits LINE-1 Retrotransposition by Interacting with ORF1p and Influencing LINE Reverse Transcriptase Activity.6
272890672016APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G.5

Citation

Dessen P

APOBEC3D (apolipoprotein B mRNA editing enzyme catalytic subunit 3D)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60427/apobec3d