APOBEC3H (apolipoprotein B mRNA editing enzyme catalytic subunit 3H)

2008-05-01  

Identity

HGNC
APOBEC3H
LOCATION
22q13.1
LOCUSID
164668
ALIAS
A3H,ARP-10,ARP10

Other Information

Locus ID:

NCBI: 164668
MIM: 610976
HGNC: 24100
Ensembl: ENSG00000100298

Variants:

dbSNP: 164668
ClinVar: 164668
TCGA: ENSG00000100298
COSMIC: APOBEC3H

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100298ENST00000348946Q6NTF7
ENSG00000100298ENST00000348946B7TQM4
ENSG00000100298ENST00000401756Q6NTF7
ENSG00000100298ENST00000421988A0A087WZI3
ENSG00000100298ENST00000442487Q6NTF7
ENSG00000100298ENST00000442487B7TQM3
ENSG00000100298ENST00000613677Q6NTF7
ENSG00000100298ENST00000613996A0A087WZI3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
mRNA EditingREACTOMER-HSA-75072
mRNA Editing: C to U ConversionREACTOMER-HSA-72200
Formation of the EditosomeREACTOMER-HSA-75094

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
184037102008Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions.139
187790512008Antiretroelement activity of APOBEC3H was lost twice in recent human evolution.121
189457812009Polymorphisms and splice variants influence the antiretroviral activity of human APOBEC3H.93
182993302008Human cytidine deaminase APOBEC3H restricts HIV-1 replication.76
212701452011Analysis of human APOBEC3H haplotypes and anti-human immunodeficiency virus type 1 activity.64
276508912016The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.59
188270272009Sole copy of Z2-type human cytidine deaminase APOBEC3H has inhibitory activity against retrotransposons and HIV-1.55
220130412012The activity spectrum of Vif from multiple HIV-1 subtypes against APOBEC3G, APOBEC3F, and APOBEC3H.54
224575292012APOBEC3A, APOBEC3B, and APOBEC3H haplotype 2 restrict human T-lymphotropic virus type 1.54
241393992013HIV-1 Vif adaptation to human APOBEC3H haplotypes.53

Citation

Dessen P

APOBEC3H (apolipoprotein B mRNA editing enzyme catalytic subunit 3H)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/50124/apobec3h