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APOC1 (apolipoprotein C1)

Identity

Alias_namesapolipoprotein C-I
Other aliasApo-CI
ApoC-I
apo-CIB
apoC-IB
HGNC (Hugo) APOC1
LocusID (NCBI) 341
Atlas_Id 50188
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 44914247 and ends at 44919349 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
APOC1 (19q13.32) / IQCE (7p22.3)APOC1 (19q13.32) / LAMA1 (18p11.31)HIVEP3 (1p34.2) / APOC1 (19q13.32)
APOC1 19q13.32 / IQCE 7p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APOC1   607
Cards
Entrez_Gene (NCBI)APOC1  341  apolipoprotein C1
AliasesApo-CI; ApoC-I; apo-CIB; apoC-IB
GeneCards (Weizmann)APOC1
Ensembl hg19 (Hinxton)ENSG00000130208 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130208 [Gene_View]  chr19:44914247-44919349 [Contig_View]  APOC1 [Vega]
ICGC DataPortalENSG00000130208
TCGA cBioPortalAPOC1
AceView (NCBI)APOC1
Genatlas (Paris)APOC1
WikiGenes341
SOURCE (Princeton)APOC1
Genetics Home Reference (NIH)APOC1
Genomic and cartography
GoldenPath hg38 (UCSC)APOC1  -     chr19:44914247-44919349 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APOC1  -     19q13.32   [Description]    (hg19-Feb_2009)
EnsemblAPOC1 - 19q13.32 [CytoView hg19]  APOC1 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIAPOC1 [Mapview hg19]  APOC1 [Mapview hg38]
OMIM107710   
Gene and transcription
Genbank (Entrez)AF308154 AF308155 AI310334 AI885116 AK225971
RefSeq transcript (Entrez)NM_001321065 NM_001321066 NM_001645
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APOC1
Cluster EST : UnigeneHs.737668 [ NCBI ]
CGAP (NCI)Hs.737668
Alternative Splicing GalleryENSG00000130208
Gene ExpressionAPOC1 [ NCBI-GEO ]   APOC1 [ EBI - ARRAY_EXPRESS ]   APOC1 [ SEEK ]   APOC1 [ MEM ]
Gene Expression Viewer (FireBrowse)APOC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)341
GTEX Portal (Tissue expression)APOC1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02654   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02654  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02654
Splice isoforms : SwissVarP02654
PhosPhoSitePlusP02654
Domains : Interpro (EBI)ApoC-I   
Domain families : Pfam (Sanger)ApoC-I (PF04691)   
Domain families : Pfam (NCBI)pfam04691   
Conserved Domain (NCBI)APOC1
DMDM Disease mutations341
Blocks (Seattle)APOC1
PDB (SRS)1ALE    1ALF    1IOJ    1OPP   
PDB (PDBSum)1ALE    1ALF    1IOJ    1OPP   
PDB (IMB)1ALE    1ALF    1IOJ    1OPP   
PDB (RSDB)1ALE    1ALF    1IOJ    1OPP   
Structural Biology KnowledgeBase1ALE    1ALF    1IOJ    1OPP   
SCOP (Structural Classification of Proteins)1ALE    1ALF    1IOJ    1OPP   
CATH (Classification of proteins structures)1ALE    1ALF    1IOJ    1OPP   
SuperfamilyP02654
Human Protein AtlasENSG00000130208
Peptide AtlasP02654
HPRD00131
IPIIPI00021855   
Protein Interaction databases
DIP (DOE-UCLA)P02654
IntAct (EBI)P02654
FunCoupENSG00000130208
BioGRIDAPOC1
STRING (EMBL)APOC1
ZODIACAPOC1
Ontologies - Pathways
QuickGOP02654
Ontology : AmiGOphospholipase inhibitor activity  fatty acid binding  extracellular region  endoplasmic reticulum  lipid metabolic process  triglyceride metabolic process  cholesterol metabolic process  positive regulation of cholesterol esterification  negative regulation of phosphatidylcholine catabolic process  negative regulation of very-low-density lipoprotein particle clearance  phosphatidylcholine binding  regulation of cholesterol transport  negative regulation of cholesterol transport  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  high-density lipoprotein particle  plasma lipoprotein particle remodeling  high-density lipoprotein particle remodeling  very-low-density lipoprotein particle assembly  chylomicron remnant clearance  very-low-density lipoprotein particle clearance  lipoprotein metabolic process  chylomicron  positive regulation of catalytic activity  negative regulation of fatty acid biosynthetic process  negative regulation of lipid metabolic process  negative regulation of receptor-mediated endocytosis  negative regulation of lipid catabolic process  negative regulation of lipoprotein lipase activity  lipase inhibitor activity  phosphatidylcholine-sterol O-acyltransferase activator activity  extracellular exosome  
Ontology : EGO-EBIphospholipase inhibitor activity  fatty acid binding  extracellular region  endoplasmic reticulum  lipid metabolic process  triglyceride metabolic process  cholesterol metabolic process  positive regulation of cholesterol esterification  negative regulation of phosphatidylcholine catabolic process  negative regulation of very-low-density lipoprotein particle clearance  phosphatidylcholine binding  regulation of cholesterol transport  negative regulation of cholesterol transport  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  high-density lipoprotein particle  plasma lipoprotein particle remodeling  high-density lipoprotein particle remodeling  very-low-density lipoprotein particle assembly  chylomicron remnant clearance  very-low-density lipoprotein particle clearance  lipoprotein metabolic process  chylomicron  positive regulation of catalytic activity  negative regulation of fatty acid biosynthetic process  negative regulation of lipid metabolic process  negative regulation of receptor-mediated endocytosis  negative regulation of lipid catabolic process  negative regulation of lipoprotein lipase activity  lipase inhibitor activity  phosphatidylcholine-sterol O-acyltransferase activator activity  extracellular exosome  
NDEx NetworkAPOC1
Atlas of Cancer Signalling NetworkAPOC1
Wikipedia pathwaysAPOC1
Orthology - Evolution
OrthoDB341
GeneTree (enSembl)ENSG00000130208
Phylogenetic Trees/Animal Genes : TreeFamAPOC1
HOVERGENP02654
HOGENOMP02654
Homologs : HomoloGeneAPOC1
Homology/Alignments : Family Browser (UCSC)APOC1
Gene fusions - Rearrangements
Fusion : MitelmanAPOC1/IQCE [19q13.32/7p22.3]  
Fusion: TCGAAPOC1 19q13.32 IQCE 7p22.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPOC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APOC1
dbVarAPOC1
ClinVarAPOC1
1000_GenomesAPOC1 
Exome Variant ServerAPOC1
ExAC (Exome Aggregation Consortium)APOC1 (select the gene name)
Genetic variants : HAPMAP341
Genomic Variants (DGV)APOC1 [DGVbeta]
DECIPHERAPOC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPOC1 
Mutations
ICGC Data PortalAPOC1 
TCGA Data PortalAPOC1 
Broad Tumor PortalAPOC1
OASIS PortalAPOC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOC1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPOC1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APOC1
DgiDB (Drug Gene Interaction Database)APOC1
DoCM (Curated mutations)APOC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOC1 (select a term)
intoGenAPOC1
Cancer3DAPOC1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107710   
Orphanet
MedgenAPOC1
Genetic Testing Registry APOC1
NextProtP02654 [Medical]
TSGene341
GENETestsAPOC1
Target ValidationAPOC1
Huge Navigator APOC1 [HugePedia]
snp3D : Map Gene to Disease341
BioCentury BCIQAPOC1
ClinGenAPOC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD341
Chemical/Pharm GKB GenePA51
Clinical trialAPOC1
Miscellaneous
canSAR (ICR)APOC1 (select the gene name)
Probes
Litterature
PubMed174 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPOC1
EVEXAPOC1
GoPubMedAPOC1
iHOPAPOC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:46:59 CEST 2017

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