Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

APOC3 (apolipoprotein C-III)

Identity

Alias_namesapolipoprotein C-III
Other aliasAPOCIII
HALP2
HGNC (Hugo) APOC3
LocusID (NCBI) 345
Atlas_Id 51037
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 116700624 and ends at 116703787 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CEP164 (11q23.3) / APOC3 (11q23.3)CEP164 11q23.3 / APOC3 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APOC3   610
Cards
Entrez_Gene (NCBI)APOC3  345  apolipoprotein C-III
AliasesAPOCIII; HALP2
GeneCards (Weizmann)APOC3
Ensembl hg19 (Hinxton)ENSG00000110245 [Gene_View]  chr11:116700624-116703787 [Contig_View]  APOC3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000110245 [Gene_View]  chr11:116700624-116703787 [Contig_View]  APOC3 [Vega]
ICGC DataPortalENSG00000110245
TCGA cBioPortalAPOC3
AceView (NCBI)APOC3
Genatlas (Paris)APOC3
WikiGenes345
SOURCE (Princeton)APOC3
Genetics Home Reference (NIH)APOC3
Genomic and cartography
GoldenPath hg19 (UCSC)APOC3  -     chr11:116700624-116703787 +  11q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)APOC3  -     11q23.3   [Description]    (hg38-Dec_2013)
EnsemblAPOC3 - 11q23.3 [CytoView hg19]  APOC3 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIAPOC3 [Mapview hg19]  APOC3 [Mapview hg38]
OMIM107720   614028   
Gene and transcription
Genbank (Entrez)BC027977 BC121081 BC134419 DQ892044 DQ895238
RefSeq transcript (Entrez)NM_000040
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_008949 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)APOC3
Cluster EST : UnigeneHs.73849 [ NCBI ]
CGAP (NCI)Hs.73849
Alternative Splicing GalleryENSG00000110245
Gene ExpressionAPOC3 [ NCBI-GEO ]   APOC3 [ EBI - ARRAY_EXPRESS ]   APOC3 [ SEEK ]   APOC3 [ MEM ]
Gene Expression Viewer (FireBrowse)APOC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)345
GTEX Portal (Tissue expression)APOC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02656   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02656  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02656
Splice isoforms : SwissVarP02656
PhosPhoSitePlusP02656
Domains : Interpro (EBI)Apo-CIII   
Domain families : Pfam (Sanger)Apo-CIII (PF05778)   
Domain families : Pfam (NCBI)pfam05778   
Domain structure : Prodom (Prabi Lyon)Apo-CIII (PD010414)   
Conserved Domain (NCBI)APOC3
DMDM Disease mutations345
Blocks (Seattle)APOC3
PDB (SRS)2JQ3   
PDB (PDBSum)2JQ3   
PDB (IMB)2JQ3   
PDB (RSDB)2JQ3   
Structural Biology KnowledgeBase2JQ3   
SCOP (Structural Classification of Proteins)2JQ3   
CATH (Classification of proteins structures)2JQ3   
SuperfamilyP02656
Human Protein AtlasENSG00000110245
Peptide AtlasP02656
HPRD00132
IPIIPI00021857   IPI00657715   IPI00657670   
Protein Interaction databases
DIP (DOE-UCLA)P02656
IntAct (EBI)P02656
FunCoupENSG00000110245
BioGRIDAPOC3
STRING (EMBL)APOC3
ZODIACAPOC3
Ontologies - Pathways
QuickGOP02656
Ontology : AmiGOretinoid metabolic process  phospholipid binding  extracellular region  extracellular space  early endosome  triglyceride metabolic process  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of triglyceride biosynthetic process  negative regulation of triglyceride catabolic process  negative regulation of very-low-density lipoprotein particle remodeling  negative regulation of very-low-density lipoprotein particle remodeling  negative regulation of very-low-density lipoprotein particle clearance  negative regulation of high-density lipoprotein particle clearance  negative regulation of low-density lipoprotein particle clearance  cholesterol binding  triglyceride catabolic process  enzyme regulator activity  regulation of Cdc42 protein signal transduction  response to vitamin A  cholesterol efflux  phospholipid efflux  response to triglyceride  very-low-density lipoprotein particle  intermediate-density lipoprotein particle  spherical high-density lipoprotein particle  high-density lipoprotein particle remodeling  very-low-density lipoprotein particle assembly  chylomicron remnant clearance  lipoprotein metabolic process  chylomicron  cholesterol homeostasis  lipoprotein transport  response to peptide hormone  reverse cholesterol transport  negative regulation of fatty acid biosynthetic process  negative regulation of lipid metabolic process  negative regulation of receptor-mediated endocytosis  negative regulation of lipid catabolic process  negative regulation of lipoprotein lipase activity  lipase inhibitor activity  negative regulation of cholesterol import  extracellular exosome  triglyceride homeostasis  response to fatty acid  high-density lipoprotein particle receptor binding  cellular response to glucose stimulus  negative regulation of oxidative phosphorylation  response to simvastatin  
Ontology : EGO-EBIretinoid metabolic process  phospholipid binding  extracellular region  extracellular space  early endosome  triglyceride metabolic process  inflammatory response  G-protein coupled receptor signaling pathway  positive regulation of triglyceride biosynthetic process  negative regulation of triglyceride catabolic process  negative regulation of very-low-density lipoprotein particle remodeling  negative regulation of very-low-density lipoprotein particle remodeling  negative regulation of very-low-density lipoprotein particle clearance  negative regulation of high-density lipoprotein particle clearance  negative regulation of low-density lipoprotein particle clearance  cholesterol binding  triglyceride catabolic process  enzyme regulator activity  regulation of Cdc42 protein signal transduction  response to vitamin A  cholesterol efflux  phospholipid efflux  response to triglyceride  very-low-density lipoprotein particle  intermediate-density lipoprotein particle  spherical high-density lipoprotein particle  high-density lipoprotein particle remodeling  very-low-density lipoprotein particle assembly  chylomicron remnant clearance  lipoprotein metabolic process  chylomicron  cholesterol homeostasis  lipoprotein transport  response to peptide hormone  reverse cholesterol transport  negative regulation of fatty acid biosynthetic process  negative regulation of lipid metabolic process  negative regulation of receptor-mediated endocytosis  negative regulation of lipid catabolic process  negative regulation of lipoprotein lipase activity  lipase inhibitor activity  negative regulation of cholesterol import  extracellular exosome  triglyceride homeostasis  response to fatty acid  high-density lipoprotein particle receptor binding  cellular response to glucose stimulus  negative regulation of oxidative phosphorylation  response to simvastatin  
Pathways : KEGGPPAR signaling pathway   
NDEx NetworkAPOC3
Atlas of Cancer Signalling NetworkAPOC3
Wikipedia pathwaysAPOC3
Orthology - Evolution
OrthoDB345
GeneTree (enSembl)ENSG00000110245
Phylogenetic Trees/Animal Genes : TreeFamAPOC3
HOVERGENP02656
HOGENOMP02656
Homologs : HomoloGeneAPOC3
Homology/Alignments : Family Browser (UCSC)APOC3
Gene fusions - Rearrangements
Fusion : MitelmanCEP164/APOC3 [11q23.3/11q23.3]  [t(11;11)(q23;q23)]  
Fusion: TCGACEP164 11q23.3 APOC3 11q23.3 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPOC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APOC3
dbVarAPOC3
ClinVarAPOC3
1000_GenomesAPOC3 
Exome Variant ServerAPOC3
ExAC (Exome Aggregation Consortium)APOC3 (select the gene name)
Genetic variants : HAPMAP345
Genomic Variants (DGV)APOC3 [DGVbeta]
DECIPHER (Syndromes)11:116700624-116703787  ENSG00000110245
CONAN: Copy Number AnalysisAPOC3 
Mutations
ICGC Data PortalAPOC3 
TCGA Data PortalAPOC3 
Broad Tumor PortalAPOC3
OASIS PortalAPOC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPOC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Pharmacogenomics of Infectious Diseases (PGx_IfD )
BioMutasearch APOC3
DgiDB (Drug Gene Interaction Database)APOC3
DoCM (Curated mutations)APOC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOC3 (select a term)
intoGenAPOC3
Cancer3DAPOC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107720    614028   
Orphanet11532   
MedgenAPOC3
Genetic Testing Registry APOC3
NextProtP02656 [Medical]
TSGene345
GENETestsAPOC3
Huge Navigator APOC3 [HugePedia]
snp3D : Map Gene to Disease345
BioCentury BCIQAPOC3
ClinGenAPOC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD345
Chemical/Pharm GKB GenePA53
Clinical trialAPOC3
Miscellaneous
canSAR (ICR)APOC3 (select the gene name)
Probes
Litterature
PubMed346 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPOC3
EVEXAPOC3
GoPubMedAPOC3
iHOPAPOC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:56:09 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.