APOC4 (apolipoprotein C4)

2014-11-01  

Identity

HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
APO-CIV,APOC-IV
FUSION GENES

Other Information

Locus ID:

NCBI: 346
MIM: 600745
HGNC: 611
Ensembl: ENSG00000267467

Variants:

dbSNP: 346
ClinVar: 346
TCGA: ENSG00000267467
COSMIC: APOC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000267467ENST00000591600K7EMC3
ENSG00000267467ENST00000592954P55056

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
VLDL interactionsREACTOMER-HSA-8855121
VLDL biosynthesisREACTOMER-HSA-8866423

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
207143482010Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits.246
208646722010Genetic variants influencing circulating lipid levels and risk of coronary artery disease.180
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120321512002Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta.58
219431582011Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.34
203313782010Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus.29
193364752009Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.27
208555652010Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.27
205717542010Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.26
204989212010APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective coronary heart disease risk among UK healthy men.23

Citation

Dessen P

APOC4 (apolipoprotein C4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60432/apoc4