Identity
HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
AD2,APO-E,ApoE4,LDLCQ5,LPG
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 348
MIM: 107741
HGNC: 613
Ensembl: ENSG00000130203
Variants:
dbSNP: 348
ClinVar: 348
TCGA: ENSG00000130203
COSMIC: APOE
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA126 | CYP2C9 | Gene | DataAnnotation | associated | |||
| PA133787052 | VKORC1 | Gene | DataAnnotation | associated | |||
| PA133950441 | hmg coa reductase inhibitors | Chemical | ClinicalAnnotation | associated | PD | ||
| PA164712505 | Antivirals for treatment of HIV infections, combinations | Chemical | ClinicalAnnotation | associated | PD | 15809899, 17700364 | |
| PA164742099 | MTTP | Gene | Pathway | associated | |||
| PA27121 | CYP4F2 | Gene | DataAnnotation | associated | |||
| PA443319 | Alzheimer Disease | Disease | ClinicalAnnotation | associated | PD | ||
| PA443797 | Coronary Disease | Disease | ClinicalAnnotation | associated | PD | 16103896, 17289397, 19667110, 20031582 | |
| PA444417 | Hemorrhage | Disease | ClinicalAnnotation | associated | PD | 29432897 | |
| PA444528 | Hyperlipidemias | Disease | ClinicalAnnotation | associated | PD | 15809899, 16103896, 17289397, 17700364, 19667110, 20031582 | |
| PA445019 | Myocardial Infarction | Disease | ClinicalAnnotation | associated | PD | 10736278 | |
| PA446120 | Hypertriglyceridemia | Disease | ClinicalAnnotation | associated | PD | 12042669, 15809899, 17700364 | |
| PA447230 | HIV Infections | Disease | ClinicalAnnotation | associated | PD | 15809899, 17700364 | |
| PA447298 | venous thromboembolism | Disease | ClinicalAnnotation | associated | PD | 29432897 | |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 16103896, 17289397, 19667110, 20031582 | |
| PA449594 | fenofibrate | Chemical | ClinicalAnnotation | associated | PD | 12042669 | |
| PA449688 | fluvastatin | Chemical | ClinicalAnnotation | associated | PD | 17289397, 30363031 | |
| PA451089 | pravastatin | Chemical | ClinicalAnnotation, LabelAnnotation | associated | PD | 17289397, 19667110 | |
| PA451260 | ritonavir | Chemical | ClinicalAnnotation | associated | PD | 15809899, 17700364 | |
| PA451363 | simvastatin | Chemical | ClinicalAnnotation | associated | PD | 10736278 | |
| PA451906 | warfarin | Chemical | ClinicalAnnotation | associated | PD | 21923605, 29432897 | |
| PA452632 | acenocoumarol | Chemical | ClinicalAnnotation, DataAnnotation | associated | PD | 29432897 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37309703 | 2024 | Obstructive sleep apnea and cognitive functioning in the older general population: The moderating effect of age, sex, ApoE4, and obesity. | 0 |
| 37577852 | 2024 | The relationship between APOE genotype, CSF Tau and cognition across the Alzheimer's disease spectrum, moderation and mediation role of insula network connectivity. | 1 |
| 37646624 | 2024 | Alzheimer's disease phenotype based upon the carrier status of the apolipoprotein E ɛ4 allele. | 1 |
| 37653269 | 2024 | Involvement of ApoE4 in dementia with Lewy bodies in the prodromal and demented stages: evaluation of the Strasbourg cohort. | 0 |
| 37679610 | 2024 | Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition. | 0 |
| 37697966 | 2024 | The roles of apolipoprotein E ε4 on neuropathology and neuroinflammation in patients with Alzheimer's disease. | 1 |
| 37700547 | 2024 | GSK-3β activation mediates apolipoprotein E4-associated cognitive impairment in type 2 diabetes mellitus: A multicenter, cross-sectional study. | 2 |
| 37710144 | 2024 | Understanding the interplay between APO E polymorphism and cognition in the Italian oldest old: results from the "Mugello study". | 0 |
| 37728850 | 2024 | Neuronal Stem Cells from Late-Onset Alzheimer Patients Show Altered Regulation of Sirtuin 1 Depending on Apolipoprotein E Indicating Disturbed Stem Cell Plasticity. | 1 |
| 37759100 | 2024 | Association of APOE gene with longitudinal changes of CSF amyloid beta and tau levels in Alzheimer's disease: racial differences. | 2 |
| 37792627 | 2024 | Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review. | 0 |
| 37801334 | 2024 | The inverse association between the apolipoprotein E ε4 allele and C-reactive protein levels is stronger in persons with obesity and diabetes. | 0 |
| 37805344 | 2024 | The cell biology of APOE in the brain. | 4 |
| 38035998 | 2024 | APOE Genotype Modifies the Association between Midlife Adherence to the Planetary Healthy Diet and Cognitive Function in Later Life among Chinese Adults in Singapore. | 1 |
| 38054895 | 2024 | The current state of apolipoprotein E in dyslipidemia. | 1 |
Citation
Dessen P
APOE (apolipoprotein E)
Atlas Genet Cytogenet Oncol Haematol. 2003-08-01
Online version: http://atlasgeneticsoncology.org/gene/677/apoe
