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APOE (apolipoprotein E)

Identity

Other namesAD2
LDLCQ5
LPG
HGNC (Hugo) APOE
LocusID (NCBI) 348
Location 19q13.32
Location_base_pair Starts at 45409039 and ends at 45412650 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)APOE   613
Cards
Entrez_Gene (NCBI)APOE  348  apolipoprotein E
GeneCards (Weizmann)APOE
Ensembl (Hinxton)ENSG00000130203 [Gene_View]  chr19:45409039-45412650 [Contig_View]  APOE [Vega]
AceView (NCBI)APOE
Genatlas (Paris)APOE
WikiGenes348
SOURCE (Princeton)NM_000041
Genomic and cartography
GoldenPath (UCSC)APOE  -  19q13.32   chr19:45409039-45412650 +  19q13.32   [Description]    (hg19-Feb_2009)
EnsemblAPOE - 19q13.32 [CytoView]
Mapping of homologs : NCBIAPOE [Mapview]
OMIM104310   107741   269600   603075   611771   
Gene and transcription
Genbank (Entrez)AK314898 BC003557 BU848796 DQ892548 DQ895759
RefSeq transcript (Entrez)NM_000041
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_007084 NT_011109 NW_001838496 NW_004929415
Consensus coding sequences : CCDS (NCBI)APOE
Cluster EST : UnigeneHs.654439 [ NCBI ]
CGAP (NCI)Hs.654439
Alternative Splicing : Fast-db (Paris)GSHG0015001
Alternative Splicing GalleryENSG00000130203
Gene ExpressionAPOE [ NCBI-GEO ]     APOE [ SEEK ]   APOE [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02649 (Uniprot)
NextProtP02649  [Medical]
With graphics : InterProP02649
Splice isoforms : SwissVarP02649 (Swissvar)
Domains : Interpro (EBI)ApoA1_A4_E   
Related proteins : CluSTrP02649
Domain families : Pfam (Sanger)Apolipoprotein (PF01442)   
Domain families : Pfam (NCBI)pfam01442   
DMDM Disease mutations348
Blocks (Seattle)P02649
PDB (SRS)1B68    1BZ4    1EA8    1GS9    1H7I    1LE2    1LE4    1LPE    1NFN    1NFO    1OEF    1OEG    1OR2    1OR3    2KC3    2KNY    2L7B   
PDB (PDBSum)1B68    1BZ4    1EA8    1GS9    1H7I    1LE2    1LE4    1LPE    1NFN    1NFO    1OEF    1OEG    1OR2    1OR3    2KC3    2KNY    2L7B   
PDB (IMB)1B68    1BZ4    1EA8    1GS9    1H7I    1LE2    1LE4    1LPE    1NFN    1NFO    1OEF    1OEG    1OR2    1OR3    2KC3    2KNY    2L7B   
PDB (RSDB)1B68    1BZ4    1EA8    1GS9    1H7I    1LE2    1LE4    1LPE    1NFN    1NFO    1OEF    1OEG    1OR2    1OR3    2KC3    2KNY    2L7B   
Human Protein AtlasENSG00000130203
Peptide AtlasP02649
HPRD00135
IPIIPI00021842   IPI00879368   IPI00878953   IPI00879456   
Protein Interaction databases
DIP (DOE-UCLA)P02649
IntAct (EBI)P02649
FunCoupENSG00000130203
BioGRIDAPOE
InParanoidP02649
Interologous Interaction database P02649
IntegromeDBAPOE
STRING (EMBL)APOE
Ontologies - Pathways
Ontology : AmiGOresponse to reactive oxygen species  retinoid metabolic process  beta-amyloid binding  negative regulation of endothelial cell proliferation  response to dietary excess  lipid transporter activity  protein binding  phospholipid binding  extracellular region  extracellular space  cytoplasm  cytoplasm  early endosome  late endosome  Golgi apparatus  plasma membrane  triglyceride metabolic process  triglyceride metabolic process  cholesterol catabolic process  cellular calcium ion homeostasis  receptor-mediated endocytosis  cytoskeleton organization  G-protein coupled receptor signaling pathway  nitric oxide mediated signal transduction  synaptic transmission, cholinergic  aging  phototransduction, visible light  heparin binding  cholesterol metabolic process  cholesterol metabolic process  cell death  lipid binding  regulation of gene expression  negative regulation of platelet activation  positive regulation of cholesterol esterification  positive regulation of cholesterol efflux  positive regulation of cholesterol efflux  peripheral nervous system axon regeneration  antioxidant activity  cholesterol transporter activity  cGMP-mediated signaling  negative regulation of blood coagulation  dendrite  regulation of axon extension  positive regulation of cGMP biosynthetic process  extrinsic to external side of plasma membrane  regulation of Cdc42 protein signal transduction  response to retinoic acid  positive regulation of low-density lipoprotein particle receptor catabolic process  response to insulin  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  low-density lipoprotein particle  intermediate-density lipoprotein particle  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  very-low-density lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  chylomicron remnant clearance  high-density lipoprotein particle clearance  very-low-density lipoprotein particle clearance  very-low-density lipoprotein particle clearance  lipoprotein metabolic process  lipoprotein biosynthetic process  lipoprotein catabolic process  vasodilation  chylomicron  cholesterol homeostasis  identical protein binding  protein homodimerization activity  neuronal cell body  negative regulation of MAP kinase activity  negative regulation of neuron apoptotic process  negative regulation of blood vessel endothelial cell migration  reverse cholesterol transport  small molecule metabolic process  response to ethanol  negative regulation of cholesterol biosynthetic process  positive regulation of axon extension  hydroxyapatite binding  intracellular transport  metal chelating activity  protein heterodimerization activity  tau protein binding  regulation of neuronal synaptic plasticity  oligodendrocyte differentiation  artery morphogenesis  negative regulation of inflammatory response  low-density lipoprotein particle receptor binding  low-density lipoprotein particle receptor binding  positive regulation of nitric-oxide synthase activity  positive regulation of membrane protein ectodomain proteolysis  maintenance of location in cell  phosphatidylcholine-sterol O-acyltransferase activator activity  very-low-density lipoprotein particle receptor binding  very-low-density lipoprotein particle receptor binding  cellular response to interleukin-1  cellular response to growth factor stimulus  cellular response to cholesterol  endocytic vesicle lumen  lipoprotein particle binding  
Ontology : EGO-EBIresponse to reactive oxygen species  retinoid metabolic process  beta-amyloid binding  negative regulation of endothelial cell proliferation  response to dietary excess  lipid transporter activity  protein binding  phospholipid binding  extracellular region  extracellular space  cytoplasm  cytoplasm  early endosome  late endosome  Golgi apparatus  plasma membrane  triglyceride metabolic process  triglyceride metabolic process  cholesterol catabolic process  cellular calcium ion homeostasis  receptor-mediated endocytosis  cytoskeleton organization  G-protein coupled receptor signaling pathway  nitric oxide mediated signal transduction  synaptic transmission, cholinergic  aging  phototransduction, visible light  heparin binding  cholesterol metabolic process  cholesterol metabolic process  cell death  lipid binding  regulation of gene expression  negative regulation of platelet activation  positive regulation of cholesterol esterification  positive regulation of cholesterol efflux  positive regulation of cholesterol efflux  peripheral nervous system axon regeneration  antioxidant activity  cholesterol transporter activity  cGMP-mediated signaling  negative regulation of blood coagulation  dendrite  regulation of axon extension  positive regulation of cGMP biosynthetic process  extrinsic to external side of plasma membrane  regulation of Cdc42 protein signal transduction  response to retinoic acid  positive regulation of low-density lipoprotein particle receptor catabolic process  response to insulin  cholesterol efflux  phospholipid efflux  very-low-density lipoprotein particle  low-density lipoprotein particle  intermediate-density lipoprotein particle  high-density lipoprotein particle  very-low-density lipoprotein particle remodeling  very-low-density lipoprotein particle remodeling  low-density lipoprotein particle remodeling  high-density lipoprotein particle remodeling  high-density lipoprotein particle assembly  chylomicron remnant clearance  high-density lipoprotein particle clearance  very-low-density lipoprotein particle clearance  very-low-density lipoprotein particle clearance  lipoprotein metabolic process  lipoprotein biosynthetic process  lipoprotein catabolic process  vasodilation  chylomicron  cholesterol homeostasis  identical protein binding  protein homodimerization activity  neuronal cell body  negative regulation of MAP kinase activity  negative regulation of neuron apoptotic process  negative regulation of blood vessel endothelial cell migration  reverse cholesterol transport  small molecule metabolic process  response to ethanol  negative regulation of cholesterol biosynthetic process  positive regulation of axon extension  hydroxyapatite binding  intracellular transport  metal chelating activity  protein heterodimerization activity  tau protein binding  regulation of neuronal synaptic plasticity  oligodendrocyte differentiation  artery morphogenesis  negative regulation of inflammatory response  low-density lipoprotein particle receptor binding  low-density lipoprotein particle receptor binding  positive regulation of nitric-oxide synthase activity  positive regulation of membrane protein ectodomain proteolysis  maintenance of location in cell  phosphatidylcholine-sterol O-acyltransferase activator activity  very-low-density lipoprotein particle receptor binding  very-low-density lipoprotein particle receptor binding  cellular response to interleukin-1  cellular response to growth factor stimulus  cellular response to cholesterol  endocytic vesicle lumen  lipoprotein particle binding  
Pathways : KEGGAlzheimer's disease   
REACTOMEAPOE
Protein Interaction DatabaseAPOE
Wikipedia pathwaysAPOE
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)APOE
SNP (GeneSNP Utah)APOE
SNP : HGBaseAPOE
Genetic variants : HAPMAPAPOE
1000_GenomesAPOE 
ICGC programENSG00000130203 
Somatic Mutations in Cancer : COSMICAPOE 
CONAN: Copy Number AnalysisAPOE 
Mutations and Diseases : HGMDAPOE
OMIM104310    107741    269600    603075    611771   
GENETestsAPOE
Disease Genetic AssociationAPOE
Huge Navigator APOE [HugePedia]  APOE [HugeCancerGEM]
Genomic VariantsAPOE  APOE [DGVbeta]
Exome VariantAPOE
dbVarAPOE
ClinVarAPOE
snp3D : Map Gene to Disease348
General knowledge
Homologs : HomoloGeneAPOE
Homology/Alignments : Family Browser (UCSC)APOE
Phylogenetic Trees/Animal Genes : TreeFamAPOE
Chemical/Protein Interactions : CTD348
Chemical/Pharm GKB GenePA55
Clinical trialAPOE
Cancer Resource (Charite)ENSG00000130203
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineAPOE
iHOPAPOE
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:15:39 CEST 2014

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