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APOL2 (apolipoprotein L2)

Identity

Alias_symbol (synonym)APOL-II
Other aliasAPOL3
HGNC (Hugo) APOL2
LocusID (NCBI) 23780
Atlas_Id 53919
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 36622255 and ends at 36635689 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
APOL2 (22q12.3) / SNCA (4q22.1)APOL2 (22q12.3) / ULK2 (17p11.2)ZFAND2A (7p22.3) / APOL2 (22q12.3)
APOL2 22q12.3 / ULK2 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)APOL2   619
Cards
Entrez_Gene (NCBI)APOL2  23780  apolipoprotein L2
AliasesAPOL-II; APOL3
GeneCards (Weizmann)APOL2
Ensembl hg19 (Hinxton)ENSG00000128335 [Gene_View]  chr22:36622255-36635689 [Contig_View]  APOL2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128335 [Gene_View]  chr22:36622255-36635689 [Contig_View]  APOL2 [Vega]
ICGC DataPortalENSG00000128335
TCGA cBioPortalAPOL2
AceView (NCBI)APOL2
Genatlas (Paris)APOL2
WikiGenes23780
SOURCE (Princeton)APOL2
Genetics Home Reference (NIH)APOL2
Genomic and cartography
GoldenPath hg19 (UCSC)APOL2  -     chr22:36622255-36635689 -  22q12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)APOL2  -     22q12.3   [Description]    (hg38-Dec_2013)
EnsemblAPOL2 - 22q12.3 [CytoView hg19]  APOL2 - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBIAPOL2 [Mapview hg19]  APOL2 [Mapview hg38]
OMIM181500   607252   
Gene and transcription
Genbank (Entrez)AB208990 AF305225 AF305429 AF324223 AF324224
RefSeq transcript (Entrez)NM_030882 NM_145637
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_023229 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)APOL2
Cluster EST : UnigeneHs.474740 [ NCBI ]
CGAP (NCI)Hs.474740
Alternative Splicing GalleryENSG00000128335
Gene ExpressionAPOL2 [ NCBI-GEO ]   APOL2 [ EBI - ARRAY_EXPRESS ]   APOL2 [ SEEK ]   APOL2 [ MEM ]
Gene Expression Viewer (FireBrowse)APOL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23780
GTEX Portal (Tissue expression)APOL2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQE5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQE5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQE5
Splice isoforms : SwissVarQ9BQE5
PhosPhoSitePlusQ9BQE5
Domains : Interpro (EBI)ApoL   
Domain families : Pfam (Sanger)ApoL (PF05461)   
Domain families : Pfam (NCBI)pfam05461   
Conserved Domain (NCBI)APOL2
DMDM Disease mutations23780
Blocks (Seattle)APOL2
SuperfamilyQ9BQE5
Human Protein AtlasENSG00000128335
Peptide AtlasQ9BQE5
HPRD06263
IPIIPI00877964   IPI00880121   IPI01012274   IPI01011797   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQE5
IntAct (EBI)Q9BQE5
FunCoupENSG00000128335
BioGRIDAPOL2
STRING (EMBL)APOL2
ZODIACAPOL2
Ontologies - Pathways
QuickGOQ9BQE5
Ontology : AmiGOreceptor binding  extracellular region  endoplasmic reticulum membrane  lipid metabolic process  lipid transport  acute-phase response  multicellular organism development  high-density lipoprotein particle binding  cholesterol metabolic process  lipid binding  membrane  lipoprotein metabolic process  maternal process involved in female pregnancy  
Ontology : EGO-EBIreceptor binding  extracellular region  endoplasmic reticulum membrane  lipid metabolic process  lipid transport  acute-phase response  multicellular organism development  high-density lipoprotein particle binding  cholesterol metabolic process  lipid binding  membrane  lipoprotein metabolic process  maternal process involved in female pregnancy  
NDEx NetworkAPOL2
Atlas of Cancer Signalling NetworkAPOL2
Wikipedia pathwaysAPOL2
Orthology - Evolution
OrthoDB23780
GeneTree (enSembl)ENSG00000128335
Phylogenetic Trees/Animal Genes : TreeFamAPOL2
HOVERGENQ9BQE5
HOGENOMQ9BQE5
Homologs : HomoloGeneAPOL2
Homology/Alignments : Family Browser (UCSC)APOL2
Gene fusions - Rearrangements
Fusion : MitelmanAPOL2/ULK2 [22q12.3/17p11.2]  
Fusion: TCGAAPOL2 22q12.3 ULK2 17p11.2 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPOL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APOL2
dbVarAPOL2
ClinVarAPOL2
1000_GenomesAPOL2 
Exome Variant ServerAPOL2
ExAC (Exome Aggregation Consortium)APOL2 (select the gene name)
Genetic variants : HAPMAP23780
Genomic Variants (DGV)APOL2 [DGVbeta]
DECIPHER (Syndromes)22:36622255-36635689  ENSG00000128335
CONAN: Copy Number AnalysisAPOL2 
Mutations
ICGC Data PortalAPOL2 
TCGA Data PortalAPOL2 
Broad Tumor PortalAPOL2
OASIS PortalAPOL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPOL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APOL2
DgiDB (Drug Gene Interaction Database)APOL2
DoCM (Curated mutations)APOL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOL2 (select a term)
intoGenAPOL2
Cancer3DAPOL2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM181500    607252   
Orphanet
MedgenAPOL2
Genetic Testing Registry APOL2
NextProtQ9BQE5 [Medical]
TSGene23780
GENETestsAPOL2
Huge Navigator APOL2 [HugePedia]
snp3D : Map Gene to Disease23780
BioCentury BCIQAPOL2
ClinGenAPOL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23780
Chemical/Pharm GKB GenePA24905
Clinical trialAPOL2
Miscellaneous
canSAR (ICR)APOL2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPOL2
EVEXAPOL2
GoPubMedAPOL2
iHOPAPOL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 14:52:43 CEST 2017

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