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APOL3 (apolipoprotein L3)

Identity

Alias_symbol (synonym)CG12-1
APOLIII
Other aliasCG121
CG12_1
apoL-III
HGNC (Hugo) APOL3
LocusID (NCBI) 80833
Atlas_Id 678
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 36140329 and ends at 36160929 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ABCA5 (17q24.3) / APOL3 (22q12.3)APOL3 (22q12.3) / COL6A3 (2q37.3)APOL3 (22q12.3) / ISX (22q12.3)
DNAJB6 (7q36.3) / APOL3 (22q12.3)ELMO1 (7p14.2) / APOL3 (22q12.3)HLA-B (6p21.33) / APOL3 (22q12.3)
NPIPA1 (16p13.11) / APOL3 (22q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)APOL3   14868
Cards
Entrez_Gene (NCBI)APOL3  80833  apolipoprotein L3
AliasesAPOLIII; CG121; CG12_1; apoL-III
GeneCards (Weizmann)APOL3
Ensembl hg19 (Hinxton)ENSG00000128284 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128284 [Gene_View]  chr22:36140329-36160929 [Contig_View]  APOL3 [Vega]
ICGC DataPortalENSG00000128284
TCGA cBioPortalAPOL3
AceView (NCBI)APOL3
Genatlas (Paris)APOL3
WikiGenes80833
SOURCE (Princeton)APOL3
Genetics Home Reference (NIH)APOL3
Genomic and cartography
GoldenPath hg38 (UCSC)APOL3  -     chr22:36140329-36160929 -  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)APOL3  -     22q12.3   [Description]    (hg19-Feb_2009)
EnsemblAPOL3 - 22q12.3 [CytoView hg19]  APOL3 - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBIAPOL3 [Mapview hg19]  APOL3 [Mapview hg38]
OMIM607253   
Gene and transcription
Genbank (Entrez)AF070675 AF305227 AK025349 AK297892 AY014902
RefSeq transcript (Entrez)NM_014349 NM_030644 NM_145639 NM_145640 NM_145641 NM_145642
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)APOL3
Cluster EST : UnigeneHs.474737 [ NCBI ]
CGAP (NCI)Hs.474737
Alternative Splicing GalleryENSG00000128284
Gene ExpressionAPOL3 [ NCBI-GEO ]   APOL3 [ EBI - ARRAY_EXPRESS ]   APOL3 [ SEEK ]   APOL3 [ MEM ]
Gene Expression Viewer (FireBrowse)APOL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80833
GTEX Portal (Tissue expression)APOL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95236   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95236  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95236
Splice isoforms : SwissVarO95236
PhosPhoSitePlusO95236
Domains : Interpro (EBI)ApoL   
Domain families : Pfam (Sanger)ApoL (PF05461)   
Domain families : Pfam (NCBI)pfam05461   
Conserved Domain (NCBI)APOL3
DMDM Disease mutations80833
Blocks (Seattle)APOL3
SuperfamilyO95236
Human Protein AtlasENSG00000128284
Peptide AtlasO95236
HPRD06264
IPIIPI00302796   IPI00335164   IPI00157607   IPI01012214   IPI00879035   IPI00879355   IPI00879527   IPI00982460   IPI01009994   IPI00984476   IPI00978616   IPI00981812   
Protein Interaction databases
DIP (DOE-UCLA)O95236
IntAct (EBI)O95236
FunCoupENSG00000128284
BioGRIDAPOL3
STRING (EMBL)APOL3
ZODIACAPOL3
Ontologies - Pathways
QuickGOO95236
Ontology : AmiGOsignal transducer activity  lipid transporter activity  extracellular region  cytoplasm  lipid transport  inflammatory response  signal transduction  lipid binding  membrane  lipoprotein metabolic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  
Ontology : EGO-EBIsignal transducer activity  lipid transporter activity  extracellular region  cytoplasm  lipid transport  inflammatory response  signal transduction  lipid binding  membrane  lipoprotein metabolic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  
NDEx NetworkAPOL3
Atlas of Cancer Signalling NetworkAPOL3
Wikipedia pathwaysAPOL3
Orthology - Evolution
OrthoDB80833
GeneTree (enSembl)ENSG00000128284
Phylogenetic Trees/Animal Genes : TreeFamAPOL3
HOVERGENO95236
HOGENOMO95236
Homologs : HomoloGeneAPOL3
Homology/Alignments : Family Browser (UCSC)APOL3
Gene fusions - Rearrangements
Fusion : MitelmanAPOL3/ISX [22q12.3/22q12.3]  
Fusion Cancer (Beijing)HLA-B [6p21.33]  -  APOL3 [22q12.3]  [FUSC003897]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerAPOL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)APOL3
dbVarAPOL3
ClinVarAPOL3
1000_GenomesAPOL3 
Exome Variant ServerAPOL3
ExAC (Exome Aggregation Consortium)APOL3 (select the gene name)
Genetic variants : HAPMAP80833
Genomic Variants (DGV)APOL3 [DGVbeta]
DECIPHERAPOL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisAPOL3 
Mutations
ICGC Data PortalAPOL3 
TCGA Data PortalAPOL3 
Broad Tumor PortalAPOL3
OASIS PortalAPOL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICAPOL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDAPOL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch APOL3
DgiDB (Drug Gene Interaction Database)APOL3
DoCM (Curated mutations)APOL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)APOL3 (select a term)
intoGenAPOL3
Cancer3DAPOL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607253   
Orphanet
MedgenAPOL3
Genetic Testing Registry APOL3
NextProtO95236 [Medical]
TSGene80833
GENETestsAPOL3
Target ValidationAPOL3
Huge Navigator APOL3 [HugePedia]
snp3D : Map Gene to Disease80833
BioCentury BCIQAPOL3
ClinGenAPOL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80833
Chemical/Pharm GKB GenePA24906
Clinical trialAPOL3
Miscellaneous
canSAR (ICR)APOL3 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineAPOL3
EVEXAPOL3
GoPubMedAPOL3
iHOPAPOL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:24:05 CEST 2017

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