Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

ARAF (A-Raf proto-oncogene, serine/threonine kinase)

Identity

Alias_namesARAF1
v-raf murine sarcoma 3611 viral oncogene homolog 1
Other aliasA-RAF
PKS2
RAFA1
HGNC (Hugo) ARAF
LocusID (NCBI) 369
Atlas_Id 686
Location Xp11.3  [Link to chromosome band Xp11]
Location_base_pair Starts at 47561100 and ends at 47571921 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARAF (Xp11.23) / ARAF (Xp11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Thyroid: Papillary Carcinoma with inv(7)(q21q34) AKAP9/BRAF


External links

Nomenclature
HGNC (Hugo)ARAF   646
Cards
Entrez_Gene (NCBI)ARAF  369  A-Raf proto-oncogene, serine/threonine kinase
AliasesA-RAF; ARAF1; PKS2; RAFA1
GeneCards (Weizmann)ARAF
Ensembl hg19 (Hinxton)ENSG00000078061 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078061 [Gene_View]  chrX:47561100-47571921 [Contig_View]  ARAF [Vega]
ICGC DataPortalENSG00000078061
TCGA cBioPortalARAF
AceView (NCBI)ARAF
Genatlas (Paris)ARAF
WikiGenes369
SOURCE (Princeton)ARAF
Genetics Home Reference (NIH)ARAF
Genomic and cartography
GoldenPath hg38 (UCSC)ARAF  -     chrX:47561100-47571921 +  Xp11.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARAF  -     Xp11.3   [Description]    (hg19-Feb_2009)
EnsemblARAF - Xp11.3 [CytoView hg19]  ARAF - Xp11.3 [CytoView hg38]
Mapping of homologs : NCBIARAF [Mapview hg19]  ARAF [Mapview hg38]
OMIM311010   
Gene and transcription
Genbank (Entrez)AB158254 AB208831 AF052136 AK130043 AK297453
RefSeq transcript (Entrez)NM_001256196 NM_001256197 NM_001654
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARAF
Cluster EST : UnigeneHs.446641 [ NCBI ]
CGAP (NCI)Hs.446641
Alternative Splicing GalleryENSG00000078061
Gene ExpressionARAF [ NCBI-GEO ]   ARAF [ EBI - ARRAY_EXPRESS ]   ARAF [ SEEK ]   ARAF [ MEM ]
Gene Expression Viewer (FireBrowse)ARAF [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)369
GTEX Portal (Tissue expression)ARAF
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10398   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10398  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10398
Splice isoforms : SwissVarP10398
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP10398
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RBD (PS50898)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)DAG/PE-bd    Kinase-like_dom    PE/DAG-bd    Prot_kinase_dom    Protein_kinase_ATP_BS    RBD_dom    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)C1_1 (PF00130)    Pkinase_Tyr (PF07714)    RBD (PF02196)   
Domain families : Pfam (NCBI)pfam00130    pfam07714    pfam02196   
Domain families : Smart (EMBL)C1 (SM00109)  RBD (SM00455)  S_TKc (SM00220)  
Conserved Domain (NCBI)ARAF
DMDM Disease mutations369
Blocks (Seattle)ARAF
PDB (SRS)1WXM    2MSE   
PDB (PDBSum)1WXM    2MSE   
PDB (IMB)1WXM    2MSE   
PDB (RSDB)1WXM    2MSE   
Structural Biology KnowledgeBase1WXM    2MSE   
SCOP (Structural Classification of Proteins)1WXM    2MSE   
CATH (Classification of proteins structures)1WXM    2MSE   
SuperfamilyP10398
Human Protein AtlasENSG00000078061
Peptide AtlasP10398
HPRD02405
IPIIPI00872240   IPI00020578   
Protein Interaction databases
DIP (DOE-UCLA)P10398
IntAct (EBI)P10398
FunCoupENSG00000078061
BioGRIDARAF
STRING (EMBL)ARAF
ZODIACARAF
Ontologies - Pathways
QuickGOP10398
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cellular_component  mitochondrion  cytosol  cytosol  cellular protein modification process  multicellular organism development  negative regulation of signal transduction  cell differentiation  mitogen-activated protein kinase kinase binding  regulation of TOR signaling  regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of peptidyl-serine phosphorylation  negative regulation of apoptotic process  metal ion binding  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cellular_component  mitochondrion  cytosol  cytosol  cellular protein modification process  multicellular organism development  negative regulation of signal transduction  cell differentiation  mitogen-activated protein kinase kinase binding  regulation of TOR signaling  regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of peptidyl-serine phosphorylation  negative regulation of apoptotic process  metal ion binding  positive regulation of ERK1 and ERK2 cascade  
Pathways : KEGG   
NDEx NetworkARAF
Atlas of Cancer Signalling NetworkARAF
Wikipedia pathwaysARAF
Orthology - Evolution
OrthoDB369
GeneTree (enSembl)ENSG00000078061
Phylogenetic Trees/Animal Genes : TreeFamARAF
HOVERGENP10398
HOGENOMP10398
Homologs : HomoloGeneARAF
Homology/Alignments : Family Browser (UCSC)ARAF
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARAF [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARAF
dbVarARAF
ClinVarARAF
1000_GenomesARAF 
Exome Variant ServerARAF
ExAC (Exome Aggregation Consortium)ARAF (select the gene name)
Genetic variants : HAPMAP369
Genomic Variants (DGV)ARAF [DGVbeta]
DECIPHERARAF [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARAF 
Mutations
ICGC Data PortalARAF 
TCGA Data PortalARAF 
Broad Tumor PortalARAF
OASIS PortalARAF [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARAF  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARAF
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ARAF
DgiDB (Drug Gene Interaction Database)ARAF
DoCM (Curated mutations)ARAF (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARAF (select a term)
intoGenARAF
Cancer3DARAF(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM311010   
Orphanet
MedgenARAF
Genetic Testing Registry ARAF
NextProtP10398 [Medical]
TSGene369
GENETestsARAF
Target ValidationARAF
Huge Navigator ARAF [HugePedia]
snp3D : Map Gene to Disease369
BioCentury BCIQARAF
ClinGenARAF
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD369
Chemical/Pharm GKB GenePA24928
Clinical trialARAF
Miscellaneous
canSAR (ICR)ARAF (select the gene name)
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARAF
EVEXARAF
GoPubMedARAF
iHOPARAF
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:57:44 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.