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ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1)

Identity

Alias_namesCENTD2
centaurin
Other alias
HGNC (Hugo) ARAP1
LocusID (NCBI) 116985
Atlas_Id 50392
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72685069 and ends at 72752389 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARAP1 (11q13.4) / FADD (11q13.3)ARAP1 (11q13.4) / MOGAT2 (11q13.5)ARAP1 (11q13.4) / RP11-831H9.11 ()
ARAP1 (11q13.4) / SDCCAG3 (9q34.3)ARAP1 (11q13.4) / USP35 (11q14.1)ATP1B1 (1q24.2) / ARAP1 (11q13.4)
MKL1 (22q13.1) / ARAP1 (11q13.4)SLC39A11 (17q24.3) / ARAP1 (11q13.4)ARAP1 11q13.4 / FADD 11q13.3
ARAP1 11q13.4 / MOGAT2 11q13.5ARAP1 11q13.4 RP11-831H9.11ARAP1 11q13.4 / USP35 11q14.1
MKL1 22q13.1 / ARAP1 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARAP1   16925
Cards
Entrez_Gene (NCBI)ARAP1  116985  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
AliasesCENTD2
GeneCards (Weizmann)ARAP1
Ensembl hg19 (Hinxton)ENSG00000186635 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186635 [Gene_View]  chr11:72685069-72752389 [Contig_View]  ARAP1 [Vega]
ICGC DataPortalENSG00000186635
TCGA cBioPortalARAP1
AceView (NCBI)ARAP1
Genatlas (Paris)ARAP1
WikiGenes116985
SOURCE (Princeton)ARAP1
Genetics Home Reference (NIH)ARAP1
Genomic and cartography
GoldenPath hg38 (UCSC)ARAP1  -     chr11:72685069-72752389 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARAP1  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblARAP1 - 11q13.4 [CytoView hg19]  ARAP1 - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIARAP1 [Mapview hg19]  ARAP1 [Mapview hg38]
OMIM606646   
Gene and transcription
Genbank (Entrez)AB018325 AF411983 AJ621557 AJ706973 AK160383
RefSeq transcript (Entrez)NM_001040118 NM_001135190 NM_015242
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARAP1
Cluster EST : UnigeneHs.503165 [ NCBI ]
CGAP (NCI)Hs.503165
Alternative Splicing GalleryENSG00000186635
Gene ExpressionARAP1 [ NCBI-GEO ]   ARAP1 [ EBI - ARRAY_EXPRESS ]   ARAP1 [ SEEK ]   ARAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116985
GTEX Portal (Tissue expression)ARAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96P48   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96P48  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96P48
Splice isoforms : SwissVarQ96P48
PhosPhoSitePlusQ96P48
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)    PH_DOMAIN (PS50003)    RA (PS50200)    RHOGAP (PS50238)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)ArfGAP    PH_dom-like    PH_domain    RA_dom    Rho_GTPase_activation_prot    RhoGAP_dom    SAM    SAM/pointed   
Domain families : Pfam (Sanger)ArfGap (PF01412)    PH (PF00169)    RA (PF00788)    RhoGAP (PF00620)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam01412    pfam00169    pfam00788    pfam00620    pfam00536   
Domain families : Smart (EMBL)ArfGap (SM00105)  PH (SM00233)  RhoGAP (SM00324)  SAM (SM00454)  
Conserved Domain (NCBI)ARAP1
DMDM Disease mutations116985
Blocks (Seattle)ARAP1
PDB (SRS)4X1V   
PDB (PDBSum)4X1V   
PDB (IMB)4X1V   
PDB (RSDB)4X1V   
Structural Biology KnowledgeBase4X1V   
SCOP (Structural Classification of Proteins)4X1V   
CATH (Classification of proteins structures)4X1V   
SuperfamilyQ96P48
Human Protein AtlasENSG00000186635
Peptide AtlasQ96P48
HPRD09440
IPIIPI00479190   IPI00220421   IPI00639996   IPI00646915   IPI00828080   IPI00441964   IPI00925583   IPI00640351   IPI01010563   IPI01009272   IPI00941533   IPI01015959   
Protein Interaction databases
DIP (DOE-UCLA)Q96P48
IntAct (EBI)Q96P48
FunCoupENSG00000186635
BioGRIDARAP1
STRING (EMBL)ARAP1
ZODIACARAP1
Ontologies - Pathways
QuickGOQ96P48
Ontology : AmiGOpositive regulation of receptor recycling  GTPase activator activity  GTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  Golgi apparatus  trans-Golgi network  cytosol  cytosol  plasma membrane  signal transduction  regulation of cell shape  actin filament reorganization involved in cell cycle  cytoplasmic vesicle  type 1 angiotensin receptor binding  Golgi cisterna membrane  intracellular membrane-bounded organelle  positive regulation of GTPase activity  positive regulation of epidermal growth factor receptor signaling pathway  metal ion binding  regulation of small GTPase mediated signal transduction  regulation of cellular component movement  positive regulation of filopodium assembly  negative regulation of stress fiber assembly  
Ontology : EGO-EBIpositive regulation of receptor recycling  GTPase activator activity  GTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  nucleoplasm  Golgi apparatus  trans-Golgi network  cytosol  cytosol  plasma membrane  signal transduction  regulation of cell shape  actin filament reorganization involved in cell cycle  cytoplasmic vesicle  type 1 angiotensin receptor binding  Golgi cisterna membrane  intracellular membrane-bounded organelle  positive regulation of GTPase activity  positive regulation of epidermal growth factor receptor signaling pathway  metal ion binding  regulation of small GTPase mediated signal transduction  regulation of cellular component movement  positive regulation of filopodium assembly  negative regulation of stress fiber assembly  
Pathways : BIOCARTAADP-Ribosylation Factor [Genes]   
Pathways : KEGGRap1 signaling pathway    Endocytosis   
NDEx NetworkARAP1
Atlas of Cancer Signalling NetworkARAP1
Wikipedia pathwaysARAP1
Orthology - Evolution
OrthoDB116985
GeneTree (enSembl)ENSG00000186635
Phylogenetic Trees/Animal Genes : TreeFamARAP1
HOVERGENQ96P48
HOGENOMQ96P48
Homologs : HomoloGeneARAP1
Homology/Alignments : Family Browser (UCSC)ARAP1
Gene fusions - Rearrangements
Fusion : MitelmanARAP1/FADD [11q13.4/11q13.3]  
Fusion : MitelmanARAP1/MOGAT2 [11q13.4/11q13.5]  [t(11;11)(q13;q13)]  
Fusion : MitelmanARAP1/USP35 [11q13.4/11q14.1]  [t(11;11)(q13;q14)]  
Fusion : MitelmanMKL1/ARAP1 [22q13.1/11q13.4]  [t(11;22)(q13;q13)]  
Fusion: TCGAARAP1 11q13.4 FADD 11q13.3 LUAD
Fusion: TCGAARAP1 11q13.4 MOGAT2 11q13.5 BRCA
Fusion: TCGAARAP1 11q13.4 RP11-831H9.11 BRCA
Fusion: TCGAARAP1 11q13.4 USP35 11q14.1 BRCA
Fusion: TCGAMKL1 22q13.1 ARAP1 11q13.4 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARAP1
dbVarARAP1
ClinVarARAP1
1000_GenomesARAP1 
Exome Variant ServerARAP1
ExAC (Exome Aggregation Consortium)ARAP1 (select the gene name)
Genetic variants : HAPMAP116985
Genomic Variants (DGV)ARAP1 [DGVbeta]
DECIPHERARAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARAP1 
Mutations
ICGC Data PortalARAP1 
TCGA Data PortalARAP1 
Broad Tumor PortalARAP1
OASIS PortalARAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARAP1
DgiDB (Drug Gene Interaction Database)ARAP1
DoCM (Curated mutations)ARAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARAP1 (select a term)
intoGenARAP1
Cancer3DARAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606646   
Orphanet
MedgenARAP1
Genetic Testing Registry ARAP1
NextProtQ96P48 [Medical]
TSGene116985
GENETestsARAP1
Target ValidationARAP1
Huge Navigator ARAP1 [HugePedia]
snp3D : Map Gene to Disease116985
BioCentury BCIQARAP1
ClinGenARAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD116985
Chemical/Pharm GKB GenePA164715867
Clinical trialARAP1
Miscellaneous
canSAR (ICR)ARAP1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARAP1
EVEXARAP1
GoPubMedARAP1
iHOPARAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 18:57:45 CEST 2017

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