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ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2)

Identity

Alias_namesCENTD1
centaurin, delta 1
Alias_symbol (synonym)PARX
Other alias
HGNC (Hugo) ARAP2
LocusID (NCBI) 116984
Atlas_Id 60453
Location 4p14  [Link to chromosome band 4p14]
Location_base_pair Starts at 36065998 and ends at 36244357 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARAP2 (4p14) / PACS1 (11q13.1)SCCPDH (1q44) / ARAP2 (4p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARAP2   16924
Cards
Entrez_Gene (NCBI)ARAP2  116984  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
AliasesCENTD1; PARX
GeneCards (Weizmann)ARAP2
Ensembl hg19 (Hinxton)ENSG00000047365 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000047365 [Gene_View]  chr4:36065998-36244357 [Contig_View]  ARAP2 [Vega]
ICGC DataPortalENSG00000047365
TCGA cBioPortalARAP2
AceView (NCBI)ARAP2
Genatlas (Paris)ARAP2
WikiGenes116984
SOURCE (Princeton)ARAP2
Genetics Home Reference (NIH)ARAP2
Genomic and cartography
GoldenPath hg38 (UCSC)ARAP2  -     chr4:36065998-36244357 -  4p14   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARAP2  -     4p14   [Description]    (hg19-Feb_2009)
EnsemblARAP2 - 4p14 [CytoView hg19]  ARAP2 - 4p14 [CytoView hg38]
Mapping of homologs : NCBIARAP2 [Mapview hg19]  ARAP2 [Mapview hg38]
OMIM606645   
Gene and transcription
Genbank (Entrez)AB011152 AF411982 AF439781 AK126864 AW274408
RefSeq transcript (Entrez)NM_015230 NM_139182
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARAP2
Cluster EST : UnigeneHs.739008 [ NCBI ]
CGAP (NCI)Hs.739008
Alternative Splicing GalleryENSG00000047365
Gene ExpressionARAP2 [ NCBI-GEO ]   ARAP2 [ EBI - ARRAY_EXPRESS ]   ARAP2 [ SEEK ]   ARAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116984
GTEX Portal (Tissue expression)ARAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WZ64   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WZ64  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WZ64
Splice isoforms : SwissVarQ8WZ64
PhosPhoSitePlusQ8WZ64
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)    PH_DOMAIN (PS50003)    RA (PS50200)    RHOGAP (PS50238)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)ArfGAP    PH_dom-like    PH_domain    RA_dom    Rho_GTPase_activation_prot    RhoGAP_dom    SAM    SAM/pointed   
Domain families : Pfam (Sanger)ArfGap (PF01412)    PH (PF00169)    RA (PF00788)    RhoGAP (PF00620)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam01412    pfam00169    pfam00788    pfam00620    pfam00536   
Domain families : Smart (EMBL)ArfGap (SM00105)  PH (SM00233)  RhoGAP (SM00324)  SAM (SM00454)  
Conserved Domain (NCBI)ARAP2
DMDM Disease mutations116984
Blocks (Seattle)ARAP2
PDB (SRS)1X40    2COD   
PDB (PDBSum)1X40    2COD   
PDB (IMB)1X40    2COD   
PDB (RSDB)1X40    2COD   
Structural Biology KnowledgeBase1X40    2COD   
SCOP (Structural Classification of Proteins)1X40    2COD   
CATH (Classification of proteins structures)1X40    2COD   
SuperfamilyQ8WZ64
Human Protein AtlasENSG00000047365
Peptide AtlasQ8WZ64
HPRD09439
IPIIPI00292471   IPI00386398   IPI00968136   IPI00966152   
Protein Interaction databases
DIP (DOE-UCLA)Q8WZ64
IntAct (EBI)Q8WZ64
FunCoupENSG00000047365
BioGRIDARAP2
STRING (EMBL)ARAP2
ZODIACARAP2
Ontologies - Pathways
QuickGOQ8WZ64
Ontology : AmiGOGTPase activator activity  phosphatidylinositol-3,4,5-trisphosphate binding  cytosol  signal transduction  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  phosphatidylinositol-3,4,5-trisphosphate binding  cytosol  signal transduction  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
Pathways : BIOCARTAADP-Ribosylation Factor [Genes]   
Pathways : KEGGRap1 signaling pathway    Endocytosis   
NDEx NetworkARAP2
Atlas of Cancer Signalling NetworkARAP2
Wikipedia pathwaysARAP2
Orthology - Evolution
OrthoDB116984
GeneTree (enSembl)ENSG00000047365
Phylogenetic Trees/Animal Genes : TreeFamARAP2
HOVERGENQ8WZ64
HOGENOMQ8WZ64
Homologs : HomoloGeneARAP2
Homology/Alignments : Family Browser (UCSC)ARAP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARAP2
dbVarARAP2
ClinVarARAP2
1000_GenomesARAP2 
Exome Variant ServerARAP2
ExAC (Exome Aggregation Consortium)ARAP2 (select the gene name)
Genetic variants : HAPMAP116984
Genomic Variants (DGV)ARAP2 [DGVbeta]
DECIPHERARAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARAP2 
Mutations
ICGC Data PortalARAP2 
TCGA Data PortalARAP2 
Broad Tumor PortalARAP2
OASIS PortalARAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARAP2
DgiDB (Drug Gene Interaction Database)ARAP2
DoCM (Curated mutations)ARAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARAP2 (select a term)
intoGenARAP2
Cancer3DARAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606645   
Orphanet
MedgenARAP2
Genetic Testing Registry ARAP2
NextProtQ8WZ64 [Medical]
TSGene116984
GENETestsARAP2
Target ValidationARAP2
Huge Navigator ARAP2 [HugePedia]
snp3D : Map Gene to Disease116984
BioCentury BCIQARAP2
ClinGenARAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD116984
Chemical/Pharm GKB GenePA164715938
Clinical trialARAP2
Miscellaneous
canSAR (ICR)ARAP2 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARAP2
EVEXARAP2
GoPubMedARAP2
iHOPARAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:01:38 CEST 2017

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