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ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3)

Identity

Alias_namesCENTD3
centaurin
Alias_symbol (synonym)FLJ21065
DRAG1
Other alias
HGNC (Hugo) ARAP3
LocusID (NCBI) 64411
Atlas_Id 52262
Location 5q31.3  [Link to chromosome band 5q31]
Location_base_pair Starts at 141653401 and ends at 141682233 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARAP3 (5q31.3) / BSDC1 (1p35.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARAP3   24097
Cards
Entrez_Gene (NCBI)ARAP3  64411  ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
AliasesCENTD3; DRAG1
GeneCards (Weizmann)ARAP3
Ensembl hg19 (Hinxton)ENSG00000120318 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120318 [Gene_View]  ENSG00000120318 [Sequence]  chr5:141653401-141682233 [Contig_View]  ARAP3 [Vega]
ICGC DataPortalENSG00000120318
TCGA cBioPortalARAP3
AceView (NCBI)ARAP3
Genatlas (Paris)ARAP3
WikiGenes64411
SOURCE (Princeton)ARAP3
Genetics Home Reference (NIH)ARAP3
Genomic and cartography
GoldenPath hg38 (UCSC)ARAP3  -     chr5:141653401-141682233 -  5q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARAP3  -     5q31.3   [Description]    (hg19-Feb_2009)
EnsemblARAP3 - 5q31.3 [CytoView hg19]  ARAP3 - 5q31.3 [CytoView hg38]
Mapping of homologs : NCBIARAP3 [Mapview hg19]  ARAP3 [Mapview hg38]
OMIM606647   
Gene and transcription
Genbank (Entrez)AJ310567 AK001579 AK024718 AK091385 AK290052
RefSeq transcript (Entrez)NM_022481
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARAP3
Cluster EST : UnigeneHs.726187 [ NCBI ]
CGAP (NCI)Hs.726187
Alternative Splicing GalleryENSG00000120318
Gene ExpressionARAP3 [ NCBI-GEO ]   ARAP3 [ EBI - ARRAY_EXPRESS ]   ARAP3 [ SEEK ]   ARAP3 [ MEM ]
Gene Expression Viewer (FireBrowse)ARAP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64411
GTEX Portal (Tissue expression)ARAP3
Human Protein AtlasENSG00000120318-ARAP3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WWN8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WWN8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WWN8
Splice isoforms : SwissVarQ8WWN8
PhosPhoSitePlusQ8WWN8
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)    PH_DOMAIN (PS50003)    RA (PS50200)    RHOGAP (PS50238)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)ArfGAP    PH_dom-like    PH_domain    RA_dom    Rho_GTPase_activation_prot    RhoGAP_dom    SAM    SAM/pointed    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)ArfGap (PF01412)    PH (PF00169)    RA (PF00788)    RhoGAP (PF00620)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam01412    pfam00169    pfam00788    pfam00620    pfam07647   
Domain families : Smart (EMBL)ArfGap (SM00105)  PH (SM00233)  RhoGAP (SM00324)  SAM (SM00454)  
Conserved Domain (NCBI)ARAP3
DMDM Disease mutations64411
Blocks (Seattle)ARAP3
PDB (SRS)2KG5    2LNW    5JCP    5JD0   
PDB (PDBSum)2KG5    2LNW    5JCP    5JD0   
PDB (IMB)2KG5    2LNW    5JCP    5JD0   
PDB (RSDB)2KG5    2LNW    5JCP    5JD0   
Structural Biology KnowledgeBase2KG5    2LNW    5JCP    5JD0   
SCOP (Structural Classification of Proteins)2KG5    2LNW    5JCP    5JD0   
CATH (Classification of proteins structures)2KG5    2LNW    5JCP    5JD0   
SuperfamilyQ8WWN8
Human Protein Atlas [tissue]ENSG00000120318-ARAP3 [tissue]
Peptide AtlasQ8WWN8
HPRD09441
IPIIPI00103380   IPI00965334   IPI00965073   IPI00964724   IPI00982882   
Protein Interaction databases
DIP (DOE-UCLA)Q8WWN8
IntAct (EBI)Q8WWN8
FunCoupENSG00000120318
BioGRIDARAP3
STRING (EMBL)ARAP3
ZODIACARAP3
Ontologies - Pathways
QuickGOQ8WWN8
Ontology : AmiGOruffle  GTPase activator activity  GTPase activator activity  GTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytoplasm  cytosol  cytoskeleton  plasma membrane  cytoskeleton organization  signal transduction  regulation of cell shape  vesicle-mediated transport  lamellipodium  negative regulation of cell migration  negative regulation of Rac protein signal transduction  negative regulation of Rho protein signal transduction  phosphatidylinositol-3,4-bisphosphate binding  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIruffle  GTPase activator activity  GTPase activator activity  GTPase activator activity  protein binding  phosphatidylinositol-3,4,5-trisphosphate binding  cytoplasm  cytosol  cytoskeleton  plasma membrane  cytoskeleton organization  signal transduction  regulation of cell shape  vesicle-mediated transport  lamellipodium  negative regulation of cell migration  negative regulation of Rac protein signal transduction  negative regulation of Rho protein signal transduction  phosphatidylinositol-3,4-bisphosphate binding  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
NDEx NetworkARAP3
Atlas of Cancer Signalling NetworkARAP3
Wikipedia pathwaysARAP3
Orthology - Evolution
OrthoDB64411
GeneTree (enSembl)ENSG00000120318
Phylogenetic Trees/Animal Genes : TreeFamARAP3
HOVERGENQ8WWN8
HOGENOMQ8WWN8
Homologs : HomoloGeneARAP3
Homology/Alignments : Family Browser (UCSC)ARAP3
Gene fusions - Rearrangements
Fusion : QuiverARAP3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARAP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARAP3
dbVarARAP3
ClinVarARAP3
1000_GenomesARAP3 
Exome Variant ServerARAP3
ExAC (Exome Aggregation Consortium)ENSG00000120318
GNOMAD BrowserENSG00000120318
Genetic variants : HAPMAP64411
Genomic Variants (DGV)ARAP3 [DGVbeta]
DECIPHERARAP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARAP3 
Mutations
ICGC Data PortalARAP3 
TCGA Data PortalARAP3 
Broad Tumor PortalARAP3
OASIS PortalARAP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARAP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARAP3
intOGen PortalARAP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARAP3
DgiDB (Drug Gene Interaction Database)ARAP3
DoCM (Curated mutations)ARAP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARAP3 (select a term)
intoGenARAP3
Cancer3DARAP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606647   
Orphanet
DisGeNETARAP3
MedgenARAP3
Genetic Testing Registry ARAP3
NextProtQ8WWN8 [Medical]
TSGene64411
GENETestsARAP3
Target ValidationARAP3
Huge Navigator ARAP3 [HugePedia]
snp3D : Map Gene to Disease64411
BioCentury BCIQARAP3
ClinGenARAP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64411
Chemical/Pharm GKB GenePA164715983
Clinical trialARAP3
Miscellaneous
canSAR (ICR)ARAP3 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARAP3
EVEXARAP3
GoPubMedARAP3
iHOPARAP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:14:38 CEST 2018

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