ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3)

2011-06-01  

Identity

HGNC
LOCATION
5q31.3
LOCUSID
ALIAS
CENTD3,DRAG1
FUSION GENES

Other Information

Locus ID:

NCBI: 64411
MIM: 606647
HGNC: 24097
Ensembl: ENSG00000120318

Variants:

dbSNP: 64411
ClinVar: 64411
TCGA: ENSG00000120318
COSMIC: ARAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120318ENST00000239440Q8WWN8
ENSG00000120318ENST00000504448Q05CH1
ENSG00000120318ENST00000508305G5E9Y3
ENSG00000120318ENST00000513878Q8WWN8
ENSG00000120318ENST00000626478G5E9Y3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
128326192003Functional reconstitution of COPI coat assembly and disassembly using chemically defined components.25
155469192004ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner.24
155699232004EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin.23
173140302007The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.16
210764692011ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion.15
231808202013Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.9
197860922010ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences.7
232395782013Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights.3
273117132016Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3.3
227504192012Identification and structural basis for a novel interaction between Vav2 and Arap3.1

Citation

Dessen P

ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52262/arap3