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ARC (activity regulated cytoskeleton associated protein)

Identity

Alias (NCBI)Arg3.1
hArc
HGNC (Hugo) ARC
HGNC Alias symbKIAA0278
Arg3.1
LocusID (NCBI) 23237
Atlas_Id 49990
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 142611049 and ends at 142614479 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ARC   648
Cards
Entrez_Gene (NCBI)ARC    activity regulated cytoskeleton associated protein
AliasesArg3.1; hArc
GeneCards (Weizmann)ARC
Ensembl hg19 (Hinxton)ENSG00000198576 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198576 [Gene_View]  ENSG00000198576 [Sequence]  chr8:142611049-142614479 [Contig_View]  ARC [Vega]
ICGC DataPortalENSG00000198576
TCGA cBioPortalARC
AceView (NCBI)ARC
Genatlas (Paris)ARC
SOURCE (Princeton)ARC
Genetics Home Reference (NIH)ARC
Genomic and cartography
GoldenPath hg38 (UCSC)ARC  -     chr8:142611049-142614479 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARC  -     8q24.3   [Description]    (hg19-Feb_2009)
GoldenPathARC - 8q24.3 [CytoView hg19]  ARC - 8q24.3 [CytoView hg38]
ImmunoBaseENSG00000198576
Genome Data Viewer NCBIARC [Mapview hg19]  
OMIM612461   
Gene and transcription
Genbank (Entrez)AF193421 AI096899 BC012321 BC075802 BI752734
RefSeq transcript (Entrez)NM_015193
Consensus coding sequences : CCDS (NCBI)ARC
Gene ExpressionARC [ NCBI-GEO ]   ARC [ EBI - ARRAY_EXPRESS ]   ARC [ SEEK ]   ARC [ MEM ]
Gene Expression Viewer (FireBrowse)ARC [ Firebrowse - Broad ]
GenevisibleExpression of ARC in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23237
GTEX Portal (Tissue expression)ARC
Human Protein AtlasENSG00000198576-ARC [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7LC44   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7LC44  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7LC44
PhosPhoSitePlusQ7LC44
Domains : Interpro (EBI)Activity-reg_cytoskelet-assoc    Arc_C   
Domain families : Pfam (Sanger)Arc_C (PF18162)   
Domain families : Pfam (NCBI)pfam18162   
Conserved Domain (NCBI)ARC
SuperfamilyQ7LC44
AlphaFold pdb e-kbQ7LC44   
Human Protein Atlas [tissue]ENSG00000198576-ARC [tissue]
HPRD12469
Protein Interaction databases
DIP (DOE-UCLA)Q7LC44
IntAct (EBI)Q7LC44
BioGRIDARC
STRING (EMBL)ARC
ZODIACARC
Ontologies - Pathways
QuickGOQ7LC44
Ontology : AmiGOacrosomal vesicle  mRNA binding  protein binding  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  cell cortex  endocytosis  cytoskeleton organization  cytoskeleton organization  endoderm development  learning  long-term memory  long-term memory  anterior/posterior pattern specification  actin cytoskeleton  cell migration  regulation of cell morphogenesis  early endosome membrane  neuronal cell body  dendritic spine  membrane raft  regulation of neuronal synaptic plasticity  modulation of chemical synaptic transmission  mRNA transport  protein homooligomerization  long-term synaptic potentiation  dendritic spine morphogenesis  regulation of dendritic spine morphogenesis  neuronal ribonucleoprotein granule  postsynaptic density membrane  postsynaptic endosome  glutamatergic synapse  regulation of postsynaptic neurotransmitter receptor internalization  vesicle-mediated intercellular transport  regulation of long-term synaptic potentiation  regulation of long-term synaptic potentiation  regulation of long-term synaptic depression  extracellular vesicle  positive regulation of AMPA receptor activity  
Ontology : EGO-EBIacrosomal vesicle  mRNA binding  protein binding  cytoplasm  cytoplasm  cytosol  plasma membrane  plasma membrane  cell cortex  endocytosis  cytoskeleton organization  cytoskeleton organization  endoderm development  learning  long-term memory  long-term memory  anterior/posterior pattern specification  actin cytoskeleton  cell migration  regulation of cell morphogenesis  early endosome membrane  neuronal cell body  dendritic spine  membrane raft  regulation of neuronal synaptic plasticity  modulation of chemical synaptic transmission  mRNA transport  protein homooligomerization  long-term synaptic potentiation  dendritic spine morphogenesis  regulation of dendritic spine morphogenesis  neuronal ribonucleoprotein granule  postsynaptic density membrane  postsynaptic endosome  glutamatergic synapse  regulation of postsynaptic neurotransmitter receptor internalization  vesicle-mediated intercellular transport  regulation of long-term synaptic potentiation  regulation of long-term synaptic potentiation  regulation of long-term synaptic depression  extracellular vesicle  positive regulation of AMPA receptor activity  
Pathways : KEGGAmphetamine addiction   
NDEx NetworkARC
Atlas of Cancer Signalling NetworkARC
Wikipedia pathwaysARC
Orthology - Evolution
OrthoDB23237
GeneTree (enSembl)ENSG00000198576
Phylogenetic Trees/Animal Genes : TreeFamARC
Homologs : HomoloGeneARC
Homology/Alignments : Family Browser (UCSC)ARC
Gene fusions - Rearrangements
Fusion : QuiverARC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARC
dbVarARC
ClinVarARC
MonarchARC
1000_GenomesARC 
Exome Variant ServerARC
GNOMAD BrowserENSG00000198576
Varsome BrowserARC
ACMGARC variants
VarityQ7LC44
Genomic Variants (DGV)ARC [DGVbeta]
DECIPHERARC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARC 
Mutations
ICGC Data PortalARC 
TCGA Data PortalARC 
Broad Tumor PortalARC
OASIS PortalARC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARC  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARC
Mutations and Diseases : HGMDARC
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARC
DgiDB (Drug Gene Interaction Database)ARC
DoCM (Curated mutations)ARC
CIViC (Clinical Interpretations of Variants in Cancer)ARC
Cancer3DARC
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612461   
Orphanet
DisGeNETARC
MedgenARC
Genetic Testing Registry ARC
NextProtQ7LC44 [Medical]
GENETestsARC
Target ValidationARC
Huge Navigator ARC [HugePedia]
ClinGenARC
Clinical trials, drugs, therapy
MyCancerGenomeARC
Protein Interactions : CTDARC
Pharm GKB GenePA24930
PharosQ7LC44
Clinical trialARC
Miscellaneous
canSAR (ICR)ARC
HarmonizomeARC
DataMed IndexARC
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:59:51 CEST 2021

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