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ARF1 (ADP ribosylation factor 1)

Identity

Other alias-
HGNC (Hugo) ARF1
LocusID (NCBI) 375
Atlas_Id 43123
Location 1q42.13  [Link to chromosome band 1q42]
Location_base_pair Starts at 228082660 and ends at 228099212 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARF1 (1q42.13) / ARF1 (1q42.13)ARF1 (1q42.13) / DCAF5 (14q24.1)ARF1 (1q42.13) / HSPA9 (5q31.2)
ARF1 (1q42.13) / PFN2 (3q25.1)ARF1 (1q42.13) / PLCD4 (2q35)ATXN7 (3p14.1) / ARF1 (1q42.13)
CTCF (16q22.1) / ARF1 (1q42.13)DCAF5 (14q24.1) / ARF1 (1q42.13)GUK1 (1q42.13) / ARF1 (1q42.13)
PDIA3 (15q15.3) / ARF1 (1q42.13)ARF1 1q42.13 / HSPA9 5q31.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(q13;q23) KMT2A/SMAP1


External links

Nomenclature
HGNC (Hugo)ARF1   652
Cards
Entrez_Gene (NCBI)ARF1  375  ADP ribosylation factor 1
Aliases
GeneCards (Weizmann)ARF1
Ensembl hg19 (Hinxton)ENSG00000143761 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143761 [Gene_View]  chr1:228082660-228099212 [Contig_View]  ARF1 [Vega]
ICGC DataPortalENSG00000143761
TCGA cBioPortalARF1
AceView (NCBI)ARF1
Genatlas (Paris)ARF1
WikiGenes375
SOURCE (Princeton)ARF1
Genetics Home Reference (NIH)ARF1
Genomic and cartography
GoldenPath hg38 (UCSC)ARF1  -     chr1:228082660-228099212 +  1q42.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARF1  -     1q42.13   [Description]    (hg19-Feb_2009)
EnsemblARF1 - 1q42.13 [CytoView hg19]  ARF1 - 1q42.13 [CytoView hg38]
Mapping of homologs : NCBIARF1 [Mapview hg19]  ARF1 [Mapview hg38]
OMIM103180   
Gene and transcription
Genbank (Entrez)AF052179 AF055002 AF493881 AK000620 AK057838
RefSeq transcript (Entrez)NM_001024226 NM_001024227 NM_001024228 NM_001658
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARF1
Cluster EST : UnigeneHs.286221 [ NCBI ]
CGAP (NCI)Hs.286221
Alternative Splicing GalleryENSG00000143761
Gene ExpressionARF1 [ NCBI-GEO ]   ARF1 [ EBI - ARRAY_EXPRESS ]   ARF1 [ SEEK ]   ARF1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)375
GTEX Portal (Tissue expression)ARF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP84077   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP84077  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP84077
Splice isoforms : SwissVarP84077
PhosPhoSitePlusP84077
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Conserved Domain (NCBI)ARF1
DMDM Disease mutations375
Blocks (Seattle)ARF1
PDB (SRS)1HUR    1RE0    1U81    3O47    4HMY   
PDB (PDBSum)1HUR    1RE0    1U81    3O47    4HMY   
PDB (IMB)1HUR    1RE0    1U81    3O47    4HMY   
PDB (RSDB)1HUR    1RE0    1U81    3O47    4HMY   
Structural Biology KnowledgeBase1HUR    1RE0    1U81    3O47    4HMY   
SCOP (Structural Classification of Proteins)1HUR    1RE0    1U81    3O47    4HMY   
CATH (Classification of proteins structures)1HUR    1RE0    1U81    3O47    4HMY   
SuperfamilyP84077
Human Protein AtlasENSG00000143761
Peptide AtlasP84077
HPRD00054
IPIIPI00215914   IPI00930263   IPI00921373   
Protein Interaction databases
DIP (DOE-UCLA)P84077
IntAct (EBI)P84077
FunCoupENSG00000143761
BioGRIDARF1
STRING (EMBL)ARF1
ZODIACARF1
Ontologies - Pathways
QuickGOP84077
Ontology : AmiGOGolgi membrane  magnesium ion binding  regulation of receptor internalization  RNA binding  GTPase activity  signal transducer activity, downstream of receptor  protein binding  GTP binding  late endosome  peroxisomal membrane  trans-Golgi network  cytosol  plasma membrane  focal adhesion  phosphatidylinositol biosynthetic process  cellular copper ion homeostasis  post-Golgi vesicle-mediated transport  actin filament organization  small GTPase mediated signal transduction  postsynaptic density  protein transport  GDP binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein domain specific binding  sarcomere  COPI-coated vesicle  cell leading edge  regulation of Arp2/3 complex-mediated actin nucleation  very-low-density lipoprotein particle assembly  neuron projection  positive regulation of catalytic activity  protein complex  postsynaptic membrane  positive regulation of endocytosis  positive regulation of calcium ion-dependent exocytosis  protein heterodimerization activity  perinuclear region of cytoplasm  regulation of defense response to virus by virus  positive regulation of protein secretion  Golgi to transport vesicle transport  long term synaptic depression  positive regulation of dendritic spine development  extracellular exosome  synaptic vesicle budding  dendritic spine organization  lysosomal membrane organization  positive regulation of sodium ion transmembrane transport  positive regulation of late endosome to lysosome transport  positive regulation of ER to Golgi vesicle-mediated transport  regulation of phospholipid metabolic process  mitotic cleavage furrow ingression  phospholipase D activator activity  
Ontology : EGO-EBIGolgi membrane  magnesium ion binding  regulation of receptor internalization  RNA binding  GTPase activity  signal transducer activity, downstream of receptor  protein binding  GTP binding  late endosome  peroxisomal membrane  trans-Golgi network  cytosol  plasma membrane  focal adhesion  phosphatidylinositol biosynthetic process  cellular copper ion homeostasis  post-Golgi vesicle-mediated transport  actin filament organization  small GTPase mediated signal transduction  postsynaptic density  protein transport  GDP binding  antigen processing and presentation of exogenous peptide antigen via MHC class II  protein domain specific binding  sarcomere  COPI-coated vesicle  cell leading edge  regulation of Arp2/3 complex-mediated actin nucleation  very-low-density lipoprotein particle assembly  neuron projection  positive regulation of catalytic activity  protein complex  postsynaptic membrane  positive regulation of endocytosis  positive regulation of calcium ion-dependent exocytosis  protein heterodimerization activity  perinuclear region of cytoplasm  regulation of defense response to virus by virus  positive regulation of protein secretion  Golgi to transport vesicle transport  long term synaptic depression  positive regulation of dendritic spine development  extracellular exosome  synaptic vesicle budding  dendritic spine organization  lysosomal membrane organization  positive regulation of sodium ion transmembrane transport  positive regulation of late endosome to lysosome transport  positive regulation of ER to Golgi vesicle-mediated transport  regulation of phospholipid metabolic process  mitotic cleavage furrow ingression  phospholipase D activator activity  
Pathways : BIOCARTAPhosphoinositides and their downstream targets. [Genes]    ADP-Ribosylation Factor [Genes]   
Pathways : KEGGVibrio cholerae infection    Legionellosis   
NDEx NetworkARF1
Atlas of Cancer Signalling NetworkARF1
Wikipedia pathwaysARF1
Orthology - Evolution
OrthoDB375
GeneTree (enSembl)ENSG00000143761
Phylogenetic Trees/Animal Genes : TreeFamARF1
HOVERGENP84077
HOGENOMP84077
Homologs : HomoloGeneARF1
Homology/Alignments : Family Browser (UCSC)ARF1
Gene fusions - Rearrangements
Fusion : MitelmanARF1/HSPA9 [1q42.13/5q31.2]  
Fusion : MitelmanGUK1/ARF1 [1q42.13/1q42.13]  [t(1;1)(q42;q42)]  
Fusion: TCGAARF1 1q42.13 HSPA9 5q31.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARF1
dbVarARF1
ClinVarARF1
1000_GenomesARF1 
Exome Variant ServerARF1
ExAC (Exome Aggregation Consortium)ARF1 (select the gene name)
Genetic variants : HAPMAP375
Genomic Variants (DGV)ARF1 [DGVbeta]
DECIPHERARF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARF1 
Mutations
ICGC Data PortalARF1 
TCGA Data PortalARF1 
Broad Tumor PortalARF1
OASIS PortalARF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARF1
DgiDB (Drug Gene Interaction Database)ARF1
DoCM (Curated mutations)ARF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARF1 (select a term)
intoGenARF1
Cancer3DARF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM103180   
Orphanet
MedgenARF1
Genetic Testing Registry ARF1
NextProtP84077 [Medical]
TSGene375
GENETestsARF1
Target ValidationARF1
Huge Navigator ARF1 [HugePedia]
snp3D : Map Gene to Disease375
BioCentury BCIQARF1
ClinGenARF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD375
Chemical/Pharm GKB GenePA24934
Clinical trialARF1
Miscellaneous
canSAR (ICR)ARF1 (select the gene name)
Probes
Litterature
PubMed191 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARF1
EVEXARF1
GoPubMedARF1
iHOPARF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:24:11 CEST 2017

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