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ARF4 (ADP ribosylation factor 4)

Identity

Alias_namesARF2
ADP-ribosylation factor 2
Other alias
HGNC (Hugo) ARF4
LocusID (NCBI) 378
Atlas_Id 43125
Location 3p14.3  [Link to chromosome band 3p14]
Location_base_pair Starts at 57557090 and ends at 57583215 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARF4 (3p14.3) / DEC1 (9q33.1)ZZZ3 (1p31.1) / ARF4 (3p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(q13;q23) KMT2A/SMAP1


External links

Nomenclature
HGNC (Hugo)ARF4   655
Cards
Entrez_Gene (NCBI)ARF4  378  ADP ribosylation factor 4
AliasesARF2
GeneCards (Weizmann)ARF4
Ensembl hg19 (Hinxton)ENSG00000168374 [Gene_View]  chr3:57557090-57583215 [Contig_View]  ARF4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168374 [Gene_View]  chr3:57557090-57583215 [Contig_View]  ARF4 [Vega]
ICGC DataPortalENSG00000168374
TCGA cBioPortalARF4
AceView (NCBI)ARF4
Genatlas (Paris)ARF4
WikiGenes378
SOURCE (Princeton)ARF4
Genetics Home Reference (NIH)ARF4
Genomic and cartography
GoldenPath hg19 (UCSC)ARF4  -     chr3:57557090-57583215 -  3p14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARF4  -     3p14.3   [Description]    (hg38-Dec_2013)
EnsemblARF4 - 3p14.3 [CytoView hg19]  ARF4 - 3p14.3 [CytoView hg38]
Mapping of homologs : NCBIARF4 [Mapview hg19]  ARF4 [Mapview hg38]
OMIM601177   
Gene and transcription
Genbank (Entrez)AF493883 AK313008 BC003364 BC008753 BC016325
RefSeq transcript (Entrez)NM_001660
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)ARF4
Cluster EST : UnigeneHs.652183 [ NCBI ]
CGAP (NCI)Hs.652183
Alternative Splicing GalleryENSG00000168374
Gene ExpressionARF4 [ NCBI-GEO ]   ARF4 [ EBI - ARRAY_EXPRESS ]   ARF4 [ SEEK ]   ARF4 [ MEM ]
Gene Expression Viewer (FireBrowse)ARF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)378
GTEX Portal (Tissue expression)ARF4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18085   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP18085  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18085
Splice isoforms : SwissVarP18085
PhosPhoSitePlusP18085
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Domain families : Smart (EMBL)ARF (SM00177)  
Conserved Domain (NCBI)ARF4
DMDM Disease mutations378
Blocks (Seattle)ARF4
PDB (SRS)1Z6X   
PDB (PDBSum)1Z6X   
PDB (IMB)1Z6X   
PDB (RSDB)1Z6X   
Structural Biology KnowledgeBase1Z6X   
SCOP (Structural Classification of Proteins)1Z6X   
CATH (Classification of proteins structures)1Z6X   
SuperfamilyP18085
Human Protein AtlasENSG00000168374
Peptide AtlasP18085
HPRD03107
IPIIPI00215918   IPI00947463   IPI00946929   IPI00944969   IPI00792330   IPI00791624   
Protein Interaction databases
DIP (DOE-UCLA)P18085
IntAct (EBI)P18085
FunCoupENSG00000168374
BioGRIDARF4
STRING (EMBL)ARF4
ZODIACARF4
Ontologies - Pathways
QuickGOP18085
Ontology : AmiGOGTPase activity  ARF guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  protein binding  GTP binding  Golgi apparatus  cytosol  cytosol  protein ADP-ribosylation  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  brain development  learning  protein transport  membrane  cell migration  activation of phospholipase D activity  ruffle membrane  negative regulation of apoptotic process  dendritic spine  positive regulation of GTPase activity  apical protein localization  establishment or maintenance of epithelial cell apical/basal polarity  positive regulation of transcription from RNA polymerase II promoter  response to axon injury  dendritic spine development  protein localization to cilium  extracellular exosome  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIGTPase activity  ARF guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  protein binding  GTP binding  Golgi apparatus  cytosol  cytosol  protein ADP-ribosylation  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  retrograde vesicle-mediated transport, Golgi to ER  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  brain development  learning  protein transport  membrane  cell migration  activation of phospholipase D activity  ruffle membrane  negative regulation of apoptotic process  dendritic spine  positive regulation of GTPase activity  apical protein localization  establishment or maintenance of epithelial cell apical/basal polarity  positive regulation of transcription from RNA polymerase II promoter  response to axon injury  dendritic spine development  protein localization to cilium  extracellular exosome  regulation of reactive oxygen species metabolic process  
NDEx NetworkARF4
Atlas of Cancer Signalling NetworkARF4
Wikipedia pathwaysARF4
Orthology - Evolution
OrthoDB378
GeneTree (enSembl)ENSG00000168374
Phylogenetic Trees/Animal Genes : TreeFamARF4
HOVERGENP18085
HOGENOMP18085
Homologs : HomoloGeneARF4
Homology/Alignments : Family Browser (UCSC)ARF4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARF4
dbVarARF4
ClinVarARF4
1000_GenomesARF4 
Exome Variant ServerARF4
ExAC (Exome Aggregation Consortium)ARF4 (select the gene name)
Genetic variants : HAPMAP378
Genomic Variants (DGV)ARF4 [DGVbeta]
DECIPHER (Syndromes)3:57557090-57583215  ENSG00000168374
CONAN: Copy Number AnalysisARF4 
Mutations
ICGC Data PortalARF4 
TCGA Data PortalARF4 
Broad Tumor PortalARF4
OASIS PortalARF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARF4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARF4
DgiDB (Drug Gene Interaction Database)ARF4
DoCM (Curated mutations)ARF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARF4 (select a term)
intoGenARF4
Cancer3DARF4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601177   
Orphanet
MedgenARF4
Genetic Testing Registry ARF4
NextProtP18085 [Medical]
TSGene378
GENETestsARF4
Huge Navigator ARF4 [HugePedia]
snp3D : Map Gene to Disease378
BioCentury BCIQARF4
ClinGenARF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD378
Chemical/Pharm GKB GenePA24937
Clinical trialARF4
Miscellaneous
canSAR (ICR)ARF4 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARF4
EVEXARF4
GoPubMedARF4
iHOPARF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:52:48 CEST 2017

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