Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARF6 (ADP ribosylation factor 6)

Identity

Other alias-
HGNC (Hugo) ARF6
LocusID (NCBI) 382
Atlas_Id 43127
Location 14q21.3  [Link to chromosome band 14q21]
Location_base_pair Starts at 49893018 and ends at 49897054 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAPK1IP1L (14q22.3) / ARF6 (14q21.3)MAPK1IP1L 14q22.3 / ARF6 14q21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(q13;q23) KMT2A/SMAP1


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(14;14)(q21;q22) MAPK1IP1L/ARF6


External links

Nomenclature
HGNC (Hugo)ARF6   659
Cards
Entrez_Gene (NCBI)ARF6  382  ADP ribosylation factor 6
Aliases
GeneCards (Weizmann)ARF6
Ensembl hg19 (Hinxton)ENSG00000165527 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165527 [Gene_View]  ENSG00000165527 [Sequence]  chr14:49893018-49897054 [Contig_View]  ARF6 [Vega]
ICGC DataPortalENSG00000165527
TCGA cBioPortalARF6
AceView (NCBI)ARF6
Genatlas (Paris)ARF6
WikiGenes382
SOURCE (Princeton)ARF6
Genetics Home Reference (NIH)ARF6
Genomic and cartography
GoldenPath hg38 (UCSC)ARF6  -     chr14:49893018-49897054 +  14q21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARF6  -     14q21.3   [Description]    (hg19-Feb_2009)
EnsemblARF6 - 14q21.3 [CytoView hg19]  ARF6 - 14q21.3 [CytoView hg38]
Mapping of homologs : NCBIARF6 [Mapview hg19]  ARF6 [Mapview hg38]
OMIM600464   
Gene and transcription
Genbank (Entrez)AF047432 AF493885 AK313790 AL117621 AL121163
RefSeq transcript (Entrez)NM_001663
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARF6
Cluster EST : UnigeneHs.719973 [ NCBI ]
CGAP (NCI)Hs.719973
Alternative Splicing GalleryENSG00000165527
Gene ExpressionARF6 [ NCBI-GEO ]   ARF6 [ EBI - ARRAY_EXPRESS ]   ARF6 [ SEEK ]   ARF6 [ MEM ]
Gene Expression Viewer (FireBrowse)ARF6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)382
GTEX Portal (Tissue expression)ARF6
Human Protein AtlasENSG00000165527-ARF6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP62330   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP62330  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP62330
Splice isoforms : SwissVarP62330
PhosPhoSitePlusP62330
Domaine pattern : Prosite (Expaxy)ARF (PS51417)   
Domains : Interpro (EBI)P-loop_NTPase    Small_GTP-bd_dom    Small_GTPase_ARF    Small_GTPase_ARF/SAR   
Domain families : Pfam (Sanger)Arf (PF00025)   
Domain families : Pfam (NCBI)pfam00025   
Conserved Domain (NCBI)ARF6
DMDM Disease mutations382
Blocks (Seattle)ARF6
PDB (SRS)1E0S    2A5D    2A5F    2A5G    2BAO    2BAU    2J5X    2W83    3LVQ    3LVR    3N5C    3PCR    4FME    4KAX   
PDB (PDBSum)1E0S    2A5D    2A5F    2A5G    2BAO    2BAU    2J5X    2W83    3LVQ    3LVR    3N5C    3PCR    4FME    4KAX   
PDB (IMB)1E0S    2A5D    2A5F    2A5G    2BAO    2BAU    2J5X    2W83    3LVQ    3LVR    3N5C    3PCR    4FME    4KAX   
PDB (RSDB)1E0S    2A5D    2A5F    2A5G    2BAO    2BAU    2J5X    2W83    3LVQ    3LVR    3N5C    3PCR    4FME    4KAX   
Structural Biology KnowledgeBase1E0S    2A5D    2A5F    2A5G    2BAO    2BAU    2J5X    2W83    3LVQ    3LVR    3N5C    3PCR    4FME    4KAX   
SCOP (Structural Classification of Proteins)1E0S    2A5D    2A5F    2A5G    2BAO    2BAU    2J5X    2W83    3LVQ    3LVR    3N5C    3PCR    4FME    4KAX   
CATH (Classification of proteins structures)1E0S    2A5D    2A5F    2A5G    2BAO    2BAU    2J5X    2W83    3LVQ    3LVR    3N5C    3PCR    4FME    4KAX   
SuperfamilyP62330
Human Protein Atlas [tissue]ENSG00000165527-ARF6 [tissue]
Peptide AtlasP62330
HPRD02714
IPIIPI00215920   
Protein Interaction databases
DIP (DOE-UCLA)P62330
IntAct (EBI)P62330
FunCoupENSG00000165527
BioGRIDARF6
STRING (EMBL)ARF6
ZODIACARF6
Ontologies - Pathways
QuickGOP62330
Ontology : AmiGOruffle  liver development  GTPase activity  protein binding  GTP binding  endosome  endosome  early endosome  Golgi apparatus  cytosol  plasma membrane  focal adhesion  cell cortex  cell cycle  cell adhesion  nervous system development  protein transport  membrane  vesicle-mediated transport  endocytic vesicle  cell differentiation  positive regulation of actin filament polymerization  cortical actin cytoskeleton organization  cortical actin cytoskeleton organization  filopodium membrane  thioesterase binding  cleavage furrow  endocytic recycling  myeloid cell apoptotic process  protein localization to cell surface  regulation of Rac protein signal transduction  protein localization to endosome  myelin sheath  protein N-terminus binding  negative regulation of receptor-mediated endocytosis  cell division  regulation of filopodium assembly  recycling endosome membrane  recycling endosome membrane  regulation of dendritic spine development  extracellular exosome  establishment of epithelial cell polarity  Flemming body  ruffle assembly  hepatocyte apoptotic process  positive regulation of protein localization to plasma membrane  negative regulation of dendrite development  
Ontology : EGO-EBIruffle  liver development  GTPase activity  protein binding  GTP binding  endosome  endosome  early endosome  Golgi apparatus  cytosol  plasma membrane  focal adhesion  cell cortex  cell cycle  cell adhesion  nervous system development  protein transport  membrane  vesicle-mediated transport  endocytic vesicle  cell differentiation  positive regulation of actin filament polymerization  cortical actin cytoskeleton organization  cortical actin cytoskeleton organization  filopodium membrane  thioesterase binding  cleavage furrow  endocytic recycling  myeloid cell apoptotic process  protein localization to cell surface  regulation of Rac protein signal transduction  protein localization to endosome  myelin sheath  protein N-terminus binding  negative regulation of receptor-mediated endocytosis  cell division  regulation of filopodium assembly  recycling endosome membrane  recycling endosome membrane  regulation of dendritic spine development  extracellular exosome  establishment of epithelial cell polarity  Flemming body  ruffle assembly  hepatocyte apoptotic process  positive regulation of protein localization to plasma membrane  negative regulation of dendrite development  
NDEx NetworkARF6
Atlas of Cancer Signalling NetworkARF6
Wikipedia pathwaysARF6
Orthology - Evolution
OrthoDB382
GeneTree (enSembl)ENSG00000165527
Phylogenetic Trees/Animal Genes : TreeFamARF6
HOVERGENP62330
HOGENOMP62330
Homologs : HomoloGeneARF6
Homology/Alignments : Family Browser (UCSC)ARF6
Gene fusions - Rearrangements
Fusion : MitelmanMAPK1IP1L/ARF6 [14q22.3/14q21.3]  [t(14;14)(q21;q22)]  
Fusion PortalMAPK1IP1L 14q22.3 ARF6 14q21.3 BRCA
Fusion : QuiverARF6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARF6
dbVarARF6
ClinVarARF6
1000_GenomesARF6 
Exome Variant ServerARF6
ExAC (Exome Aggregation Consortium)ENSG00000165527
GNOMAD BrowserENSG00000165527
Genetic variants : HAPMAP382
Genomic Variants (DGV)ARF6 [DGVbeta]
DECIPHERARF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARF6 
Mutations
ICGC Data PortalARF6 
TCGA Data PortalARF6 
Broad Tumor PortalARF6
OASIS PortalARF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARF6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARF6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARF6
DgiDB (Drug Gene Interaction Database)ARF6
DoCM (Curated mutations)ARF6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARF6 (select a term)
intoGenARF6
Cancer3DARF6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600464   
Orphanet
DisGeNETARF6
MedgenARF6
Genetic Testing Registry ARF6
NextProtP62330 [Medical]
TSGene382
GENETestsARF6
Target ValidationARF6
Huge Navigator ARF6 [HugePedia]
snp3D : Map Gene to Disease382
BioCentury BCIQARF6
ClinGenARF6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD382
Chemical/Pharm GKB GenePA24942
Clinical trialARF6
Miscellaneous
canSAR (ICR)ARF6 (select the gene name)
Probes
Litterature
PubMed216 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARF6
EVEXARF6
GoPubMedARF6
iHOPARF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:14:40 CEST 2018

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