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ARFGAP1 (ADP ribosylation factor GTPase activating protein 1)

Identity

Alias_namesARF1GAP
ADP-ribosylation factor 1 GTPase activating protein
Alias_symbol (synonym)FLJ10767
bA261N11.3
Other aliasHRIHFB2281
HGNC (Hugo) ARFGAP1
LocusID (NCBI) 55738
Atlas_Id 60455
Location 20q13.33  [Link to chromosome band 20q13]
Location_base_pair Starts at 63272785 and ends at 63289790 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARFGAP1 (20q13.33) / ARFGAP1 (20q13.33)ARFGAP1 (20q13.33) / SPAG4 (20q11.22)GUK1 (1q42.13) / ARFGAP1 (20q13.33)
SEC31A (4q21.22) / ARFGAP1 (20q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARFGAP1   15852
Cards
Entrez_Gene (NCBI)ARFGAP1  55738  ADP ribosylation factor GTPase activating protein 1
AliasesARF1GAP; HRIHFB2281
GeneCards (Weizmann)ARFGAP1
Ensembl hg19 (Hinxton)ENSG00000101199 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101199 [Gene_View]  chr20:63272785-63289790 [Contig_View]  ARFGAP1 [Vega]
ICGC DataPortalENSG00000101199
TCGA cBioPortalARFGAP1
AceView (NCBI)ARFGAP1
Genatlas (Paris)ARFGAP1
WikiGenes55738
SOURCE (Princeton)ARFGAP1
Genetics Home Reference (NIH)ARFGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)ARFGAP1  -     chr20:63272785-63289790 +  20q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARFGAP1  -     20q13.33   [Description]    (hg19-Feb_2009)
EnsemblARFGAP1 - 20q13.33 [CytoView hg19]  ARFGAP1 - 20q13.33 [CytoView hg38]
Mapping of homologs : NCBIARFGAP1 [Mapview hg19]  ARFGAP1 [Mapview hg38]
OMIM608377   
Gene and transcription
Genbank (Entrez)AA565406 AB015340 AK001629 AK027268 AK027441
RefSeq transcript (Entrez)NM_001281482 NM_001281483 NM_001281484 NM_018209 NM_175609
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARFGAP1
Cluster EST : UnigeneHs.25584 [ NCBI ]
CGAP (NCI)Hs.25584
Alternative Splicing GalleryENSG00000101199
Gene ExpressionARFGAP1 [ NCBI-GEO ]   ARFGAP1 [ EBI - ARRAY_EXPRESS ]   ARFGAP1 [ SEEK ]   ARFGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARFGAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55738
GTEX Portal (Tissue expression)ARFGAP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N6T3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N6T3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N6T3
Splice isoforms : SwissVarQ8N6T3
PhosPhoSitePlusQ8N6T3
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)   
Domains : Interpro (EBI)ArfGAP   
Domain families : Pfam (Sanger)ArfGap (PF01412)   
Domain families : Pfam (NCBI)pfam01412   
Domain families : Smart (EMBL)ArfGap (SM00105)  
Conserved Domain (NCBI)ARFGAP1
DMDM Disease mutations55738
Blocks (Seattle)ARFGAP1
PDB (SRS)3DWD    3O47   
PDB (PDBSum)3DWD    3O47   
PDB (IMB)3DWD    3O47   
PDB (RSDB)3DWD    3O47   
Structural Biology KnowledgeBase3DWD    3O47   
SCOP (Structural Classification of Proteins)3DWD    3O47   
CATH (Classification of proteins structures)3DWD    3O47   
SuperfamilyQ8N6T3
Human Protein AtlasENSG00000101199
Peptide AtlasQ8N6T3
HPRD06443
IPIIPI00175169   IPI00217354   IPI00449160   IPI00922590   IPI01014630   IPI01020998   IPI00984211   IPI01023007   IPI00973726   IPI00983453   IPI00974085   IPI00977182   
Protein Interaction databases
DIP (DOE-UCLA)Q8N6T3
IntAct (EBI)Q8N6T3
FunCoupENSG00000101199
BioGRIDARFGAP1
STRING (EMBL)ARFGAP1
ZODIACARFGAP1
Ontologies - Pathways
QuickGOQ8N6T3
Ontology : AmiGOGTPase activator activity  protein binding  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  postsynaptic density  protein transport  regulation of endocytosis  IRE1-mediated unfolded protein response  positive regulation of GTPase activity  metal ion binding  
Ontology : EGO-EBIGTPase activator activity  protein binding  Golgi apparatus  cytosol  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  postsynaptic density  protein transport  regulation of endocytosis  IRE1-mediated unfolded protein response  positive regulation of GTPase activity  metal ion binding  
Pathways : BIOCARTAADP-Ribosylation Factor [Genes]   
Pathways : KEGGEndocytosis   
NDEx NetworkARFGAP1
Atlas of Cancer Signalling NetworkARFGAP1
Wikipedia pathwaysARFGAP1
Orthology - Evolution
OrthoDB55738
GeneTree (enSembl)ENSG00000101199
Phylogenetic Trees/Animal Genes : TreeFamARFGAP1
HOVERGENQ8N6T3
HOGENOMQ8N6T3
Homologs : HomoloGeneARFGAP1
Homology/Alignments : Family Browser (UCSC)ARFGAP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARFGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARFGAP1
dbVarARFGAP1
ClinVarARFGAP1
1000_GenomesARFGAP1 
Exome Variant ServerARFGAP1
ExAC (Exome Aggregation Consortium)ARFGAP1 (select the gene name)
Genetic variants : HAPMAP55738
Genomic Variants (DGV)ARFGAP1 [DGVbeta]
DECIPHERARFGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARFGAP1 
Mutations
ICGC Data PortalARFGAP1 
TCGA Data PortalARFGAP1 
Broad Tumor PortalARFGAP1
OASIS PortalARFGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARFGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARFGAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARFGAP1
DgiDB (Drug Gene Interaction Database)ARFGAP1
DoCM (Curated mutations)ARFGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARFGAP1 (select a term)
intoGenARFGAP1
Cancer3DARFGAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608377   
Orphanet
MedgenARFGAP1
Genetic Testing Registry ARFGAP1
NextProtQ8N6T3 [Medical]
TSGene55738
GENETestsARFGAP1
Huge Navigator ARFGAP1 [HugePedia]
snp3D : Map Gene to Disease55738
BioCentury BCIQARFGAP1
ClinGenARFGAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55738
Chemical/Pharm GKB GenePA164741246
Clinical trialARFGAP1
Miscellaneous
canSAR (ICR)ARFGAP1 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARFGAP1
EVEXARFGAP1
GoPubMedARFGAP1
iHOPARFGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 11:00:38 CEST 2017

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