Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARFGAP2 (ADP ribosylation factor GTPase activating protein 2)

Identity

Alias_namesZNF289
zinc finger protein 289, ID1 regulated
Alias_symbol (synonym)IRZ
Zfp289
FLJ14576
Other aliasNBLA10535
ZFP289
HGNC (Hugo) ARFGAP2
LocusID (NCBI) 84364
Atlas_Id 60456
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 47164298 and ends at 47177125 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARFGAP2 (11p11.2) / ARFGAP2 (11p11.2)ARFGAP2 (11p11.2) / CELF1 (11p11.2)ARFGAP2 (11p11.2) / FBRSL1 (12q24.33)
ARFGAP2 (11p11.2) / PEMT (17p11.2)ARFGAP2 (11p11.2) / SH3GL2 (9p22.2)ARFGAP2 CELF1
ARFGAP2 FBRSL1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARFGAP2   13504
Cards
Entrez_Gene (NCBI)ARFGAP2  84364  ADP ribosylation factor GTPase activating protein 2
AliasesIRZ; NBLA10535; ZFP289; ZNF289
GeneCards (Weizmann)ARFGAP2
Ensembl hg19 (Hinxton)ENSG00000149182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149182 [Gene_View]  chr11:47164298-47177125 [Contig_View]  ARFGAP2 [Vega]
ICGC DataPortalENSG00000149182
TCGA cBioPortalARFGAP2
AceView (NCBI)ARFGAP2
Genatlas (Paris)ARFGAP2
WikiGenes84364
SOURCE (Princeton)ARFGAP2
Genetics Home Reference (NIH)ARFGAP2
Genomic and cartography
GoldenPath hg38 (UCSC)ARFGAP2  -     chr11:47164298-47177125 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARFGAP2  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblARFGAP2 - 11p11.2 [CytoView hg19]  ARFGAP2 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIARFGAP2 [Mapview hg19]  ARFGAP2 [Mapview hg38]
OMIM606908   
Gene and transcription
Genbank (Entrez)AB073358 AK027482 AK098324 AK129511 AK300347
RefSeq transcript (Entrez)NM_001242832 NM_032389
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARFGAP2
Cluster EST : UnigeneHs.436204 [ NCBI ]
CGAP (NCI)Hs.436204
Alternative Splicing GalleryENSG00000149182
Gene ExpressionARFGAP2 [ NCBI-GEO ]   ARFGAP2 [ EBI - ARRAY_EXPRESS ]   ARFGAP2 [ SEEK ]   ARFGAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)ARFGAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84364
GTEX Portal (Tissue expression)ARFGAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N6H7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N6H7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N6H7
Splice isoforms : SwissVarQ8N6H7
PhosPhoSitePlusQ8N6H7
Domaine pattern : Prosite (Expaxy)ARFGAP (PS50115)   
Domains : Interpro (EBI)ArfGAP   
Domain families : Pfam (Sanger)ArfGap (PF01412)   
Domain families : Pfam (NCBI)pfam01412   
Domain families : Smart (EMBL)ArfGap (SM00105)  
Conserved Domain (NCBI)ARFGAP2
DMDM Disease mutations84364
Blocks (Seattle)ARFGAP2
PDB (SRS)2P57   
PDB (PDBSum)2P57   
PDB (IMB)2P57   
PDB (RSDB)2P57   
Structural Biology KnowledgeBase2P57   
SCOP (Structural Classification of Proteins)2P57   
CATH (Classification of proteins structures)2P57   
SuperfamilyQ8N6H7
Human Protein AtlasENSG00000149182
Peptide AtlasQ8N6H7
HPRD06069
IPIIPI00297322   IPI00903129   IPI00941529   IPI00937554   IPI00976984   IPI00983468   IPI00985421   IPI00982291   IPI00981113   IPI00978642   IPI00984632   IPI00976281   IPI00922903   IPI00979436   IPI00978021   IPI00980023   IPI00977720   IPI00982389   
Protein Interaction databases
DIP (DOE-UCLA)Q8N6H7
IntAct (EBI)Q8N6H7
FunCoupENSG00000149182
BioGRIDARFGAP2
STRING (EMBL)ARFGAP2
ZODIACARFGAP2
Ontologies - Pathways
QuickGOQ8N6H7
Ontology : AmiGOGolgi membrane  GTPase activator activity  Golgi apparatus  cytosol  cytosol  plasma membrane  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  protein transport  positive regulation of GTPase activity  metal ion binding  
Ontology : EGO-EBIGolgi membrane  GTPase activator activity  Golgi apparatus  cytosol  cytosol  plasma membrane  ER to Golgi vesicle-mediated transport  retrograde vesicle-mediated transport, Golgi to ER  protein transport  positive regulation of GTPase activity  metal ion binding  
Pathways : KEGGEndocytosis   
NDEx NetworkARFGAP2
Atlas of Cancer Signalling NetworkARFGAP2
Wikipedia pathwaysARFGAP2
Orthology - Evolution
OrthoDB84364
GeneTree (enSembl)ENSG00000149182
Phylogenetic Trees/Animal Genes : TreeFamARFGAP2
HOVERGENQ8N6H7
HOGENOMQ8N6H7
Homologs : HomoloGeneARFGAP2
Homology/Alignments : Family Browser (UCSC)ARFGAP2
Gene fusions - Rearrangements
Fusion: TCGAARFGAP2 CELF1
Fusion: TCGAARFGAP2 FBRSL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARFGAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARFGAP2
dbVarARFGAP2
ClinVarARFGAP2
1000_GenomesARFGAP2 
Exome Variant ServerARFGAP2
ExAC (Exome Aggregation Consortium)ARFGAP2 (select the gene name)
Genetic variants : HAPMAP84364
Genomic Variants (DGV)ARFGAP2 [DGVbeta]
DECIPHERARFGAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARFGAP2 
Mutations
ICGC Data PortalARFGAP2 
TCGA Data PortalARFGAP2 
Broad Tumor PortalARFGAP2
OASIS PortalARFGAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARFGAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARFGAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARFGAP2
DgiDB (Drug Gene Interaction Database)ARFGAP2
DoCM (Curated mutations)ARFGAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARFGAP2 (select a term)
intoGenARFGAP2
Cancer3DARFGAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606908   
Orphanet
MedgenARFGAP2
Genetic Testing Registry ARFGAP2
NextProtQ8N6H7 [Medical]
TSGene84364
GENETestsARFGAP2
Target ValidationARFGAP2
Huge Navigator ARFGAP2 [HugePedia]
snp3D : Map Gene to Disease84364
BioCentury BCIQARFGAP2
ClinGenARFGAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84364
Chemical/Pharm GKB GenePA162376868
Clinical trialARFGAP2
Miscellaneous
canSAR (ICR)ARFGAP2 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARFGAP2
EVEXARFGAP2
GoPubMedARFGAP2
iHOPARFGAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:01:38 CEST 2017

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