ARFGAP2 (ADP ribosylation factor GTPase activating protein 2)

2014-11-01  

Identity

HGNC
LOCATION
11p11.2
LOCUSID
ALIAS
IRZ,NBLA10535,ZFP289,ZNF289
FUSION GENES

Other Information

Locus ID:

NCBI: 84364
MIM: 606908
HGNC: 13504
Ensembl: ENSG00000149182

Variants:

dbSNP: 84364
ClinVar: 84364
TCGA: ENSG00000149182
COSMIC: ARFGAP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149182ENST00000426335G5E9L0
ENSG00000149182ENST00000524586E9PM63
ENSG00000149182ENST00000524782Q8N6H7
ENSG00000149182ENST00000525314E9PN48
ENSG00000149182ENST00000525398E9PIY6
ENSG00000149182ENST00000526342E9PMU9
ENSG00000149182ENST00000527776H0YDN9
ENSG00000149182ENST00000527927E9PQP3
ENSG00000149182ENST00000528041E9PNY8
ENSG00000149182ENST00000528444E9PK28
ENSG00000149182ENST00000528708H0YCL1
ENSG00000149182ENST00000529439H0YCA3
ENSG00000149182ENST00000529455H0YDX1
ENSG00000149182ENST00000530596E9PJT7
ENSG00000149182ENST00000532438E9PMR9
ENSG00000149182ENST00000532478H0YF45
ENSG00000149182ENST00000533243E9PM18
ENSG00000149182ENST00000627920A0A0D9SF70
ENSG00000149182ENST00000629231E9PM18

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177608592007Two human ARFGAPs associated with COP-I-coated vesicles.34
190153192008Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.31
192995152009Three homologous ArfGAPs participate in coat protein I-mediated transport.19
208589012010ARFGAP2 and ARFGAP3 are essential for COPI coat assembly on the Golgi membrane of living cells.11
223758482012Distinct role of subcomplexes of the COPI coat in the regulation of ArfGAP2 activity.5

Citation

Dessen P

ARFGAP2 (ADP ribosylation factor GTPase activating protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60456/arfgap2