ARFGAP3 (ADP ribosylation factor GTPase activating protein 3)

2012-05-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
ARFGAP1
FUSION GENES

Other Information

Locus ID:

NCBI: 26286
MIM: 612439
HGNC: 661
Ensembl: ENSG00000242247

Variants:

dbSNP: 26286
ClinVar: 26286
TCGA: ENSG00000242247
COSMIC: ARFGAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242247ENST00000263245Q9NP61
ENSG00000242247ENST00000263245A0A024R4U0
ENSG00000242247ENST00000435208B0QYV9
ENSG00000242247ENST00000437119Q9NP61
ENSG00000242247ENST00000453516H0Y6A0
ENSG00000242247ENST00000454099B0QYV8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
177608592007Two human ARFGAPs associated with COP-I-coated vesicles.34
190153192008Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking.31
192995152009Three homologous ArfGAPs participate in coat protein I-mediated transport.19
216478752012ARFGAP3, an androgen target gene, promotes prostate cancer cell proliferation and migration.13
240762382013ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment.11

Citation

Dessen P

ARFGAP3 (ADP ribosylation factor GTPase activating protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52719/arfgap3