Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARFGEF2 (ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited))

Identity

Other namesBIG2
PVNH2
dJ1164I10.1
HGNC (Hugo) ARFGEF2
LocusID (NCBI) 10564
Location 20q13.13
Location_base_pair Starts at 47538275 and ends at 47653230 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ARFGEF2   15853
Entrez_Gene (NCBI)ARFGEF2  10564  ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Cards
GeneCards (Weizmann)ARFGEF2
Ensembl (Hinxton)ENSG00000124198 [Gene_View]  chr20:47538275-47653230 [Contig_View]  ARFGEF2 [Vega]
AceView (NCBI)ARFGEF2
Genatlas (Paris)ARFGEF2
SOURCE (Stanford)NM_006420
Genomic and cartography
GoldenPath (UCSC)ARFGEF2  -  20q13.13   chr20:47538275-47653230 +  20q13.13   [Description]    (hg19-Feb_2009)
EnsemblARFGEF2 - 20q13.13 [CytoView]
Mapping of homologs : NCBIARFGEF2 [Mapview]
OMIM605371   608097   
Gene and transcription
Genbank (Entrez)AB209397 AF084521 AK022623 AK074303 AK302526
RefSeq transcript (SRS)NM_006420
RefSeq transcript (Entrez)NM_006420
RefSeq genomic (SRS)AC_000152 NC_000020 NC_018931 NG_011490 NT_011362 NW_001838666 NW_004078102
RefSeq genomic (Entrez)AC_000152 NC_000020 NC_018931 NG_011490 NT_011362 NW_001838666 NW_004078102
Consensus coding sequences : CCDS (NCBI)ARFGEF2
Cluster EST : UnigeneHs.62578 [ SRS ] Hs.62578 [ NCBI ]
CGAP (NCI)Hs.62578
Alternative Splicing : Fast-db (Paris)GSHG0018817
Alternative Splicing GalleryENSG00000124198
Gene ExpressionARFGEF2 [ NCBI-GEO ]   ARFGEF2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6D5 (SRS) Q9Y6D5 (Uniprot)
NextProtQ9Y6D5
With graphics : InterProQ9Y6D5
Splice isoforms : SwissVarQ9Y6D5(Swissvar)
Domaine pattern : Prosite (SRS)SEC7 (PS50190)   
Domaine pattern : Prosite (Expaxy)SEC7 (PS50190)   
Domains : Interpro (SRS)ARM-like    ARM-type_fold    DUF1981_SEC7_assoc    Sec7    SEC7_alpha_orthog   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    DUF1981_SEC7_assoc    Sec7    SEC7_alpha_orthog   
Related proteins : CluSTrQ9Y6D5
Domain families : Pfam (SRS)DUF1981 (PF09324)    Sec7 (PF01369)   
Domain families : Pfam (Sanger)DUF1981 (PF09324)    Sec7 (PF01369)   
Domain families : Pfam (NCBI)pfam09324    pfam01369   
Domain families : Smart (EMBL)Sec7 (SM00222)  
DMDM10564
Blocks (Seattle)Q9Y6D5
PDB (SRS)3L8N    3SWV   
PDB (PDBSum)3L8N    3SWV   
PDB (IMB)3L8N    3SWV   
PDB (RSDB)3L8N    3SWV   
Human Protein AtlasENSG00000124198
HPRD09250
IPIIPI00002186   IPI01011126   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6D5
IntAct (EBI)Q9Y6D5
FunCoupENSG00000124198
REACTOMEARFGEF2
Protein Interaction Database10564
BioGRIDARFGEF2
InParanoidQ9Y6D5
Interologous Interaction database Q9Y6D5
IntegromeDBARFGEF2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ARFGEF2
SNP (GeneSNP Utah)ARFGEF2
SNP : HGBaseARFGEF2
Genetic variants : HAPMAPARFGEF2
Somatic Mutations in Cancer : COSMICARFGEF2 
CONAN: Copy Number AnalysisARFGEF2 
Mutations and Diseases : HGMDARFGEF2
OMIM605371    608097   
GENETests605371    608097   
Disease Genetic AssociationARFGEF2
Huge Navigator ARFGEF2 [HugePedia]  ARFGEF2 [HugeCancerGEM]
Genomic VariantsARFGEF2  ARFGEF2 [DGVbeta]
snp3D : Map Gene to Disease10564
General knowledge
Homologs : HomoloGeneARFGEF2
Homology/Alignments : Family Browser (UCSC)ARFGEF2
Phylogenetic Trees/Animal Genes : TreeFamARFGEF2
Chemical/Protein Interactions : CTD10564
Chemical/Pharm GKB GenePA24945
Clinical trialARFGEF2
Cancer Resource (Charite)ENSG00000124198
Ontology : AmiGOGolgi membrane  receptor recycling  guanyl-nucleotide exchange factor activity  ARF guanyl-nucleotide exchange factor activity  ARF guanyl-nucleotide exchange factor activity  protein binding  trans-Golgi network  trans-Golgi network  microtubule organizing center  cytosol  axonemal microtubule  exocytosis  Golgi to plasma membrane transport  endosome organization  endomembrane system organization  protein transport  membrane  cytoplasmic membrane-bounded vesicle  vesicle-mediated transport  myosin binding  cell junction  cytoplasmic vesicle  regulation of ARF protein signal transduction  asymmetric synapse  symmetric synapse  positive regulation of tumor necrosis factor production  protein kinase A regulatory subunit binding  intracellular signal transduction  dendritic spine  perinuclear region of cytoplasm  GABA receptor binding  recycling endosome  
Ontology : EGO-EBIGolgi membrane  receptor recycling  guanyl-nucleotide exchange factor activity  ARF guanyl-nucleotide exchange factor activity  ARF guanyl-nucleotide exchange factor activity  protein binding  trans-Golgi network  trans-Golgi network  microtubule organizing center  cytosol  axonemal microtubule  exocytosis  Golgi to plasma membrane transport  endosome organization  endomembrane system organization  protein transport  membrane  cytoplasmic membrane-bounded vesicle  vesicle-mediated transport  myosin binding  cell junction  cytoplasmic vesicle  regulation of ARF protein signal transduction  asymmetric synapse  symmetric synapse  positive regulation of tumor necrosis factor production  protein kinase A regulatory subunit binding  intracellular signal transduction  dendritic spine  perinuclear region of cytoplasm  GABA receptor binding  recycling endosome  
Pathways : BIOCARTAADP-Ribosylation Factor [Genes]   
Other databases
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
PubGeneARFGEF2
iHOPARFGEF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:28:33 CEST 2013
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