ARFRP1 (ADP ribosylation factor related protein 1)

2003-06-01  

Identity

HGNC
LOCATION
20q13.33
LOCUSID
ALIAS
ARL18,ARP,Arp1
FUSION GENES

Other Information

Locus ID:

NCBI: 10139
MIM: 604699
HGNC: 662
Ensembl: ENSG00000101246

Variants:

dbSNP: 10139
ClinVar: 10139
TCGA: ENSG00000101246
COSMIC: ARFRP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101246ENST00000607873Q13795
ENSG00000101246ENST00000612157Q13795
ENSG00000101246ENST00000612256Q13795
ENSG00000101246ENST00000614942Q13795
ENSG00000101246ENST00000618568Q13795
ENSG00000101246ENST00000618838Q13795
ENSG00000101246ENST00000618838A0A384P5U7
ENSG00000101246ENST00000619493Q13795
ENSG00000101246ENST00000619493A0A384P5U7
ENSG00000101246ENST00000622789Q13795
ENSG00000101246ENST00000622789A0A384P5U7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
233266402013A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network.35
161298872005Roles of ARFRP1 (ADP-ribosylation factor-related protein 1) in post-Golgi membrane trafficking.22
192249222009Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes.18
171276202006Knockout of Arfrp1 leads to disruption of ARF-like1 (ARL1) targeting to the trans-Golgi in mouse embryos and HeLa cells.17
225055852012The GTPase ARFRP1 controls the lipidation of chylomicrons in the Golgi of the intestinal epithelium.11
268810672015A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.1
283564832017Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization.1
303485222018The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells.1
315756032019ARFRP1 functions upstream of ARL1 and ARL5 to coordinate recruitment of distinct tethering factors to the trans-Golgi network.1
275501442016ADP-ribosylation Factor-related Protein 1 Interacts with NS5A and Regulates Hepatitis C Virus Propagation.0

Citation

Dessen P

ARFRP1 (ADP ribosylation factor related protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/692/arfrp1