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ARG1 (arginase 1)

Identity

Alias_namesarginase
Other alias-
HGNC (Hugo) ARG1
LocusID (NCBI) 383
Atlas_Id 43917
Location 6q23.2  [Link to chromosome band 6q23]
Location_base_pair Starts at 131573204 and ends at 131584332 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATXN1 (6p22.3) / ARG1 (6q23.2)MAP7 (6q23.3) / ARG1 (6q23.2)ATXN1 6p22.3 / ARG1 6q23.2
MAP7 6q23.3 / ARG1 6q23.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p22;q23) ATXN1/ARG1
MAP7/ARG1 (6q23)


External links

Nomenclature
HGNC (Hugo)ARG1   663
Cards
Entrez_Gene (NCBI)ARG1  383  arginase 1
Aliases
GeneCards (Weizmann)ARG1
Ensembl hg19 (Hinxton)ENSG00000118520 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118520 [Gene_View]  ENSG00000118520 [Sequence]  chr6:131573204-131584332 [Contig_View]  ARG1 [Vega]
ICGC DataPortalENSG00000118520
TCGA cBioPortalARG1
AceView (NCBI)ARG1
Genatlas (Paris)ARG1
WikiGenes383
SOURCE (Princeton)ARG1
Genetics Home Reference (NIH)ARG1
Genomic and cartography
GoldenPath hg38 (UCSC)ARG1  -     chr6:131573204-131584332 +  6q23.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARG1  -     6q23.2   [Description]    (hg19-Feb_2009)
EnsemblARG1 - 6q23.2 [CytoView hg19]  ARG1 - 6q23.2 [CytoView hg38]
Mapping of homologs : NCBIARG1 [Mapview hg19]  ARG1 [Mapview hg38]
OMIM207800   608313   
Gene and transcription
Genbank (Entrez)AK128314 AW236349 AY074488 BC005321 BC020653
RefSeq transcript (Entrez)NM_000045 NM_001244438
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARG1
Cluster EST : UnigeneHs.440934 [ NCBI ]
CGAP (NCI)Hs.440934
Alternative Splicing GalleryENSG00000118520
Gene ExpressionARG1 [ NCBI-GEO ]   ARG1 [ EBI - ARRAY_EXPRESS ]   ARG1 [ SEEK ]   ARG1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)383
GTEX Portal (Tissue expression)ARG1
Human Protein AtlasENSG00000118520-ARG1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05089   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05089  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05089
Splice isoforms : SwissVarP05089
PhosPhoSitePlusP05089
Domaine pattern : Prosite (Expaxy)ARGINASE_1 (PS01053)    ARGINASE_2 (PS51409)   
Domains : Interpro (EBI)Arginase    Ureohydrolase    Ureohydrolase_dom_sf    Ureohydrolase_Mn_BS   
Domain families : Pfam (Sanger)Arginase (PF00491)   
Domain families : Pfam (NCBI)pfam00491   
Conserved Domain (NCBI)ARG1
DMDM Disease mutations383
Blocks (Seattle)ARG1
PDB (SRS)1WVA    1WVB    2AEB    2PHA    2PHO    2PLL    2ZAV    3DJ8    3E6K    3E6V    3F80    3GMZ    3GN0    3KV2    3LP4    3LP7    3MFV    3MFW    3MJL    3SJT    3SKK    3TF3    3TH7    3THE    3THH    3THJ    4FCI    4FCK    4GSM    4GSV    4GSZ    4GWC    4GWD    4HWW    4HXQ    4IE1   
PDB (PDBSum)1WVA    1WVB    2AEB    2PHA    2PHO    2PLL    2ZAV    3DJ8    3E6K    3E6V    3F80    3GMZ    3GN0    3KV2    3LP4    3LP7    3MFV    3MFW    3MJL    3SJT    3SKK    3TF3    3TH7    3THE    3THH    3THJ    4FCI    4FCK    4GSM    4GSV    4GSZ    4GWC    4GWD    4HWW    4HXQ    4IE1   
PDB (IMB)1WVA    1WVB    2AEB    2PHA    2PHO    2PLL    2ZAV    3DJ8    3E6K    3E6V    3F80    3GMZ    3GN0    3KV2    3LP4    3LP7    3MFV    3MFW    3MJL    3SJT    3SKK    3TF3    3TH7    3THE    3THH    3THJ    4FCI    4FCK    4GSM    4GSV    4GSZ    4GWC    4GWD    4HWW    4HXQ    4IE1   
PDB (RSDB)1WVA    1WVB    2AEB    2PHA    2PHO    2PLL    2ZAV    3DJ8    3E6K    3E6V    3F80    3GMZ    3GN0    3KV2    3LP4    3LP7    3MFV    3MFW    3MJL    3SJT    3SKK    3TF3    3TH7    3THE    3THH    3THJ    4FCI    4FCK    4GSM    4GSV    4GSZ    4GWC    4GWD    4HWW    4HXQ    4IE1   
Structural Biology KnowledgeBase1WVA    1WVB    2AEB    2PHA    2PHO    2PLL    2ZAV    3DJ8    3E6K    3E6V    3F80    3GMZ    3GN0    3KV2    3LP4    3LP7    3MFV    3MFW    3MJL    3SJT    3SKK    3TF3    3TH7    3THE    3THH    3THJ    4FCI    4FCK    4GSM    4GSV    4GSZ    4GWC    4GWD    4HWW    4HXQ    4IE1   
SCOP (Structural Classification of Proteins)1WVA    1WVB    2AEB    2PHA    2PHO    2PLL    2ZAV    3DJ8    3E6K    3E6V    3F80    3GMZ    3GN0    3KV2    3LP4    3LP7    3MFV    3MFW    3MJL    3SJT    3SKK    3TF3    3TH7    3THE    3THH    3THJ    4FCI    4FCK    4GSM    4GSV    4GSZ    4GWC    4GWD    4HWW    4HXQ    4IE1   
CATH (Classification of proteins structures)1WVA    1WVB    2AEB    2PHA    2PHO    2PLL    2ZAV    3DJ8    3E6K    3E6V    3F80    3GMZ    3GN0    3KV2    3LP4    3LP7    3MFV    3MFW    3MJL    3SJT    3SKK    3TF3    3TH7    3THE    3THH    3THJ    4FCI    4FCK    4GSM    4GSV    4GSZ    4GWC    4GWD    4HWW    4HXQ    4IE1   
SuperfamilyP05089
Human Protein Atlas [tissue]ENSG00000118520-ARG1 [tissue]
Peptide AtlasP05089
HPRD01947
IPIIPI00291560   IPI00398768   IPI00038356   
Protein Interaction databases
DIP (DOE-UCLA)P05089
IntAct (EBI)P05089
FunCoupENSG00000118520
BioGRIDARG1
STRING (EMBL)ARG1
ZODIACARG1
Ontologies - Pathways
QuickGOP05089
Ontology : AmiGOurea cycle  urea cycle  liver development  positive regulation of endothelial cell proliferation  adaptive immune response  arginase activity  arginase activity  protein binding  extracellular region  extracellular space  nucleus  cytoplasm  cytoplasm  mitochondrial outer membrane  cytosol  cytosol  arginine catabolic process  aging  response to herbicide  response to manganese ion  response to zinc ion  response to selenium ion  regulation of L-arginine import  response to amine  arginine catabolic process to ornithine  arginine catabolic process to ornithine  manganese ion binding  manganese ion binding  lung development  collagen biosynthetic process  response to vitamin A  response to vitamin E  azurophil granule lumen  specific granule lumen  negative regulation of T cell proliferation  defense response to protozoan  neuron projection  neuronal cell body  response to amino acid  neutrophil degranulation  innate immune response  negative regulation of activated T cell proliferation  response to cadmium ion  response to axon injury  response to methylmercury  mammary gland involution  maternal process involved in female pregnancy  negative regulation of interferon-gamma-mediated signaling pathway  protein homotrimerization  cellular response to hydrogen peroxide  positive regulation of neutrophil mediated killing of fungus  cellular response to lipopolysaccharide  cellular response to interleukin-4  cellular response to glucagon stimulus  cellular response to dexamethasone stimulus  cellular response to transforming growth factor beta stimulus  negative regulation of T-helper 2 cell cytokine production  
Ontology : EGO-EBIurea cycle  urea cycle  liver development  positive regulation of endothelial cell proliferation  adaptive immune response  arginase activity  arginase activity  protein binding  extracellular region  extracellular space  nucleus  cytoplasm  cytoplasm  mitochondrial outer membrane  cytosol  cytosol  arginine catabolic process  aging  response to herbicide  response to manganese ion  response to zinc ion  response to selenium ion  regulation of L-arginine import  response to amine  arginine catabolic process to ornithine  arginine catabolic process to ornithine  manganese ion binding  manganese ion binding  lung development  collagen biosynthetic process  response to vitamin A  response to vitamin E  azurophil granule lumen  specific granule lumen  negative regulation of T cell proliferation  defense response to protozoan  neuron projection  neuronal cell body  response to amino acid  neutrophil degranulation  innate immune response  negative regulation of activated T cell proliferation  response to cadmium ion  response to axon injury  response to methylmercury  mammary gland involution  maternal process involved in female pregnancy  negative regulation of interferon-gamma-mediated signaling pathway  protein homotrimerization  cellular response to hydrogen peroxide  positive regulation of neutrophil mediated killing of fungus  cellular response to lipopolysaccharide  cellular response to interleukin-4  cellular response to glucagon stimulus  cellular response to dexamethasone stimulus  cellular response to transforming growth factor beta stimulus  negative regulation of T-helper 2 cell cytokine production  
Pathways : KEGGArginine and proline metabolism    Amoebiasis   
NDEx NetworkARG1
Atlas of Cancer Signalling NetworkARG1
Wikipedia pathwaysARG1
Orthology - Evolution
OrthoDB383
GeneTree (enSembl)ENSG00000118520
Phylogenetic Trees/Animal Genes : TreeFamARG1
HOVERGENP05089
HOGENOMP05089
Homologs : HomoloGeneARG1
Homology/Alignments : Family Browser (UCSC)ARG1
Gene fusions - Rearrangements
Fusion : MitelmanATXN1/ARG1 [6p22.3/6q23.2]  [t(6;6)(p22;q23)]  
Fusion : MitelmanMAP7/ARG1 [6q23.3/6q23.2]  [t(6;6)(q23;q23)]  
Fusion PortalATXN1 6p22.3 ARG1 6q23.2 LUAD
Fusion PortalMAP7 6q23.3 ARG1 6q23.2 BRCA
Fusion : QuiverARG1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARG1
dbVarARG1
ClinVarARG1
1000_GenomesARG1 
Exome Variant ServerARG1
ExAC (Exome Aggregation Consortium)ENSG00000118520
GNOMAD BrowserENSG00000118520
Varsome BrowserARG1
Genetic variants : HAPMAP383
Genomic Variants (DGV)ARG1 [DGVbeta]
DECIPHERARG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARG1 
Mutations
ICGC Data PortalARG1 
TCGA Data PortalARG1 
Broad Tumor PortalARG1
OASIS PortalARG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch ARG1
DgiDB (Drug Gene Interaction Database)ARG1
DoCM (Curated mutations)ARG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARG1 (select a term)
intoGenARG1
Cancer3DARG1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM207800    608313   
Orphanet417   
DisGeNETARG1
MedgenARG1
Genetic Testing Registry ARG1
NextProtP05089 [Medical]
TSGene383
GENETestsARG1
Target ValidationARG1
Huge Navigator ARG1 [HugePedia]
snp3D : Map Gene to Disease383
BioCentury BCIQARG1
ClinGenARG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD383
Chemical/Pharm GKB GenePA24947
Clinical trialARG1
Miscellaneous
canSAR (ICR)ARG1 (select the gene name)
Probes
Litterature
PubMed159 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARG1
EVEXARG1
GoPubMedARG1
iHOPARG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:09:44 CEST 2018

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