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ARHGAP1 (Rho GTPase activating protein 1)

Identity

Alias (NCBI)CDC42GAP
RHOGAP
RHOGAP1
p50rhoGAP
HGNC (Hugo) ARHGAP1
HGNC Alias symbRhoGAP
p50rhoGAP
CDC42GAP
Cdc42GAP
LocusID (NCBI) 392
Atlas_Id 694
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46677081 and ends at 46700619 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMBRA1 (11p11.2) / ARHGAP1 (11p11.2)DPP9 (19p13.3) / ARHGAP1 (11p11.2)GLIS3 (9p24.2) / ARHGAP1 (11p11.2)
MCU (10q22.1) / ARHGAP1 (11p11.2)PHF21A (11p11.2) / ARHGAP1 (11p11.2)PPP6R3 (11q13.2) / ARHGAP1 (11p11.2)
SERINC2 (1p35.2) / ARHGAP1 (11p11.2)AMBRA1 11p11.2 / ARHGAP1 11p11.2GLIS3 9p24.2 / ARHGAP1 11p11.2
PHF21A 11p11.2 / ARHGAP1 11p11.2PPP6R3 11q13.2 / ARHGAP1 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)ARHGAP1   673
Cards
Entrez_Gene (NCBI)ARHGAP1    Rho GTPase activating protein 1
AliasesCDC42GAP; RHOGAP; RHOGAP1; p50rhoGAP
GeneCards (Weizmann)ARHGAP1
Ensembl hg19 (Hinxton)ENSG00000175220 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175220 [Gene_View]  ENSG00000175220 [Sequence]  chr11:46677081-46700619 [Contig_View]  ARHGAP1 [Vega]
ICGC DataPortalENSG00000175220
TCGA cBioPortalARHGAP1
AceView (NCBI)ARHGAP1
Genatlas (Paris)ARHGAP1
SOURCE (Princeton)ARHGAP1
Genetics Home Reference (NIH)ARHGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP1  -     chr11:46677081-46700619 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP1  -     11p11.2   [Description]    (hg19-Feb_2009)
GoldenPathARHGAP1 - 11p11.2 [CytoView hg19]  ARHGAP1 - 11p11.2 [CytoView hg38]
ImmunoBaseENSG00000175220
genome Data Viewer NCBIARHGAP1 [Mapview hg19]  
OMIM602732   
Gene and transcription
Genbank (Entrez)AI640658 AK126404 AK298562 AK307296 AK310605
RefSeq transcript (Entrez)NM_004308
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP1
Alternative Splicing GalleryENSG00000175220
Gene ExpressionARHGAP1 [ NCBI-GEO ]   ARHGAP1 [ EBI - ARRAY_EXPRESS ]   ARHGAP1 [ SEEK ]   ARHGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP1 [ Firebrowse - Broad ]
GenevisibleExpression of ARHGAP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)392
GTEX Portal (Tissue expression)ARHGAP1
Human Protein AtlasENSG00000175220-ARHGAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07960   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07960  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07960
Splice isoforms : SwissVarQ07960
PhosPhoSitePlusQ07960
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    RHOGAP (PS50238)   
Domains : Interpro (EBI)CRAL-TRIO_dom    CRAL-TRIO_dom_sf    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)CRAL_TRIO_2 (PF13716)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam13716    pfam00620   
Domain families : Smart (EMBL)RhoGAP (SM00324)  SEC14 (SM00516)  
Conserved Domain (NCBI)ARHGAP1
Blocks (Seattle)ARHGAP1
PDB (RSDB)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR    5M6X    5M70    6R3V   
PDB Europe1AM4    1GRN    1OW3    1RGP    1TX4    2NGR    5M6X    5M70    6R3V   
PDB (PDBSum)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR    5M6X    5M70    6R3V   
PDB (IMB)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR    5M6X    5M70    6R3V   
Structural Biology KnowledgeBase1AM4    1GRN    1OW3    1RGP    1TX4    2NGR    5M6X    5M70    6R3V   
SCOP (Structural Classification of Proteins)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR    5M6X    5M70    6R3V   
CATH (Classification of proteins structures)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR    5M6X    5M70    6R3V   
SuperfamilyQ07960
Human Protein Atlas [tissue]ENSG00000175220-ARHGAP1 [tissue]
Peptide AtlasQ07960
HPRD04108
IPIIPI00020567   IPI00941730   IPI00382580   IPI00980090   IPI00978293   
Protein Interaction databases
DIP (DOE-UCLA)Q07960
IntAct (EBI)Q07960
BioGRIDARHGAP1
STRING (EMBL)ARHGAP1
ZODIACARHGAP1
Ontologies - Pathways
QuickGOQ07960
Ontology : AmiGOGTPase activator activity  protein binding  cytoplasm  cytosol  small GTPase mediated signal transduction  Rho protein signal transduction  endosome membrane  endosomal transport  SH3 domain binding  small GTPase binding  transferrin transport  positive regulation of GTPase activity  cadherin binding  perinuclear region of cytoplasm  regulation of small GTPase mediated signal transduction  extracellular exosome  sorting endosome  negative regulation of endocytic recycling  
Ontology : EGO-EBIGTPase activator activity  protein binding  cytoplasm  cytosol  small GTPase mediated signal transduction  Rho protein signal transduction  endosome membrane  endosomal transport  SH3 domain binding  small GTPase binding  transferrin transport  positive regulation of GTPase activity  cadherin binding  perinuclear region of cytoplasm  regulation of small GTPase mediated signal transduction  extracellular exosome  sorting endosome  negative regulation of endocytic recycling  
Pathways : BIOCARTARho cell motility signaling pathway [Genes]   
NDEx NetworkARHGAP1
Atlas of Cancer Signalling NetworkARHGAP1
Wikipedia pathwaysARHGAP1
Orthology - Evolution
OrthoDB392
GeneTree (enSembl)ENSG00000175220
Phylogenetic Trees/Animal Genes : TreeFamARHGAP1
HOGENOMQ07960
Homologs : HomoloGeneARHGAP1
Homology/Alignments : Family Browser (UCSC)ARHGAP1
Gene fusions - Rearrangements
Fusion : MitelmanAMBRA1/ARHGAP1 [11p11.2/11p11.2]  
Fusion : MitelmanGLIS3/ARHGAP1 [9p24.2/11p11.2]  
Fusion : MitelmanPHF21A/ARHGAP1 [11p11.2/11p11.2]  
Fusion : MitelmanPPP6R3/ARHGAP1 [11q13.2/11p11.2]  
Fusion PortalAMBRA1 11p11.2 ARHGAP1 11p11.2 LUAD
Fusion PortalGLIS3 9p24.2 ARHGAP1 11p11.2 LUAD
Fusion PortalPHF21A 11p11.2 ARHGAP1 11p11.2 BLCA
Fusion PortalPPP6R3 11q13.2 ARHGAP1 11p11.2 LUSC
Fusion : QuiverARHGAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP1 [hg38]
dbVarARHGAP1
ClinVarARHGAP1
MonarchARHGAP1
1000_GenomesARHGAP1 
Exome Variant ServerARHGAP1
GNOMAD BrowserENSG00000175220
Varsome BrowserARHGAP1
Genomic Variants (DGV)ARHGAP1 [DGVbeta]
DECIPHERARHGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP1 
Mutations
ICGC Data PortalARHGAP1 
TCGA Data PortalARHGAP1 
Broad Tumor PortalARHGAP1
OASIS PortalARHGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARHGAP1
Mutations and Diseases : HGMDARHGAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP1
DgiDB (Drug Gene Interaction Database)ARHGAP1
DoCM (Curated mutations)ARHGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP1 (select a term)
intoGenARHGAP1
Cancer3DARHGAP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602732   
Orphanet
DisGeNETARHGAP1
MedgenARHGAP1
Genetic Testing Registry ARHGAP1
NextProtQ07960 [Medical]
GENETestsARHGAP1
Target ValidationARHGAP1
Huge Navigator ARHGAP1 [HugePedia]
ClinGenARHGAP1
Clinical trials, drugs, therapy
MyCancerGenomeARHGAP1
Protein Interactions : CTD
Pharm GKB GenePA24956
PharosQ07960
Clinical trialARHGAP1
Miscellaneous
canSAR (ICR)ARHGAP1 (select the gene name)
HarmonizomeARHGAP1
DataMed IndexARHGAP1
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARHGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:11:26 CET 2021

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