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ARHGAP1 (Rho GTPase activating protein 1)

Identity

Alias_symbol (synonym)RhoGAP
p50rhoGAP
CDC42GAP
Cdc42GAP
Other aliasRHOGAP
RHOGAP1
HGNC (Hugo) ARHGAP1
LocusID (NCBI) 392
Atlas_Id 694
Location 11p11.2  [Link to chromosome band 11p11]
Location_base_pair Starts at 46677075 and ends at 46700665 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMBRA1 (11p11.2) / ARHGAP1 (11p11.2)DPP9 (19p13.3) / ARHGAP1 (11p11.2)GLIS3 (9p24.2) / ARHGAP1 (11p11.2)
MCU (10q22.1) / ARHGAP1 (11p11.2)PHF21A (11p11.2) / ARHGAP1 (11p11.2)PPP6R3 (11q13.2) / ARHGAP1 (11p11.2)
SERINC2 (1p35.2) / ARHGAP1 (11p11.2)AMBRA1 11p11.2 / ARHGAP1 11p11.2GLIS3 9p24.2 / ARHGAP1 11p11.2
PHF21A 11p11.2 / ARHGAP1 11p11.2PPP6R3 11q13.2 / ARHGAP1 11p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP1   673
Cards
Entrez_Gene (NCBI)ARHGAP1  392  Rho GTPase activating protein 1
AliasesCDC42GAP; RHOGAP; RHOGAP1; p50rhoGAP
GeneCards (Weizmann)ARHGAP1
Ensembl hg19 (Hinxton)ENSG00000175220 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000175220 [Gene_View]  chr11:46677075-46700665 [Contig_View]  ARHGAP1 [Vega]
ICGC DataPortalENSG00000175220
TCGA cBioPortalARHGAP1
AceView (NCBI)ARHGAP1
Genatlas (Paris)ARHGAP1
WikiGenes392
SOURCE (Princeton)ARHGAP1
Genetics Home Reference (NIH)ARHGAP1
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP1  -     chr11:46677075-46700665 -  11p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP1  -     11p11.2   [Description]    (hg19-Feb_2009)
EnsemblARHGAP1 - 11p11.2 [CytoView hg19]  ARHGAP1 - 11p11.2 [CytoView hg38]
Mapping of homologs : NCBIARHGAP1 [Mapview hg19]  ARHGAP1 [Mapview hg38]
OMIM602732   
Gene and transcription
Genbank (Entrez)AI640658 AK126404 AK298562 AK307296 AK310605
RefSeq transcript (Entrez)NM_004308
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP1
Cluster EST : UnigeneHs.138860 [ NCBI ]
CGAP (NCI)Hs.138860
Alternative Splicing GalleryENSG00000175220
Gene ExpressionARHGAP1 [ NCBI-GEO ]   ARHGAP1 [ EBI - ARRAY_EXPRESS ]   ARHGAP1 [ SEEK ]   ARHGAP1 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)392
GTEX Portal (Tissue expression)ARHGAP1
Human Protein AtlasENSG00000175220-ARHGAP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07960   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07960  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07960
Splice isoforms : SwissVarQ07960
PhosPhoSitePlusQ07960
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    RHOGAP (PS50238)   
Domains : Interpro (EBI)CRAL-TRIO_dom    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)CRAL_TRIO_2 (PF13716)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam13716    pfam00620   
Domain families : Smart (EMBL)RhoGAP (SM00324)  SEC14 (SM00516)  
Conserved Domain (NCBI)ARHGAP1
DMDM Disease mutations392
Blocks (Seattle)ARHGAP1
PDB (SRS)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR   
PDB (PDBSum)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR   
PDB (IMB)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR   
PDB (RSDB)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR   
Structural Biology KnowledgeBase1AM4    1GRN    1OW3    1RGP    1TX4    2NGR   
SCOP (Structural Classification of Proteins)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR   
CATH (Classification of proteins structures)1AM4    1GRN    1OW3    1RGP    1TX4    2NGR   
SuperfamilyQ07960
Human Protein Atlas [tissue]ENSG00000175220-ARHGAP1 [tissue]
Peptide AtlasQ07960
HPRD04108
IPIIPI00020567   IPI00941730   IPI00382580   IPI00980090   IPI00978293   
Protein Interaction databases
DIP (DOE-UCLA)Q07960
IntAct (EBI)Q07960
FunCoupENSG00000175220
BioGRIDARHGAP1
STRING (EMBL)ARHGAP1
ZODIACARHGAP1
Ontologies - Pathways
QuickGOQ07960
Ontology : AmiGOSH3/SH2 adaptor activity  GTPase activator activity  GTPase activator activity  protein binding  cytoplasm  cytosol  small GTPase mediated signal transduction  Rho protein signal transduction  positive regulation of signal transduction  endosome membrane  SH3 domain binding  Rab GTPase binding  endosome localization  transferrin transport  positive regulation of GTPase activity  cadherin binding  perinuclear region of cytoplasm  regulation of small GTPase mediated signal transduction  extracellular exosome  sorting endosome  ferric iron import across plasma membrane  negative regulation of endocytic recycling  
Ontology : EGO-EBISH3/SH2 adaptor activity  GTPase activator activity  GTPase activator activity  protein binding  cytoplasm  cytosol  small GTPase mediated signal transduction  Rho protein signal transduction  positive regulation of signal transduction  endosome membrane  SH3 domain binding  Rab GTPase binding  endosome localization  transferrin transport  positive regulation of GTPase activity  cadherin binding  perinuclear region of cytoplasm  regulation of small GTPase mediated signal transduction  extracellular exosome  sorting endosome  ferric iron import across plasma membrane  negative regulation of endocytic recycling  
Pathways : BIOCARTARho cell motility signaling pathway [Genes]   
NDEx NetworkARHGAP1
Atlas of Cancer Signalling NetworkARHGAP1
Wikipedia pathwaysARHGAP1
Orthology - Evolution
OrthoDB392
GeneTree (enSembl)ENSG00000175220
Phylogenetic Trees/Animal Genes : TreeFamARHGAP1
HOVERGENQ07960
HOGENOMQ07960
Homologs : HomoloGeneARHGAP1
Homology/Alignments : Family Browser (UCSC)ARHGAP1
Gene fusions - Rearrangements
Fusion : MitelmanAMBRA1/ARHGAP1 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion : MitelmanGLIS3/ARHGAP1 [9p24.2/11p11.2]  [t(9;11)(p24;p11)]  
Fusion : MitelmanPHF21A/ARHGAP1 [11p11.2/11p11.2]  [t(11;11)(p11;p11)]  
Fusion : MitelmanPPP6R3/ARHGAP1 [11q13.2/11p11.2]  [t(11;11)(p11;q13)]  
Fusion: TCGA_MDACCAMBRA1 11p11.2 ARHGAP1 11p11.2 LUAD
Fusion: TCGA_MDACCGLIS3 9p24.2 ARHGAP1 11p11.2 LUAD
Fusion: TCGA_MDACCPHF21A 11p11.2 ARHGAP1 11p11.2 BLCA
Fusion: TCGA_MDACCPPP6R3 11q13.2 ARHGAP1 11p11.2 LUSC
Tumor Fusion PortalARHGAP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP1
dbVarARHGAP1
ClinVarARHGAP1
1000_GenomesARHGAP1 
Exome Variant ServerARHGAP1
ExAC (Exome Aggregation Consortium)ENSG00000175220
GNOMAD BrowserENSG00000175220
Genetic variants : HAPMAP392
Genomic Variants (DGV)ARHGAP1 [DGVbeta]
DECIPHERARHGAP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP1 
Mutations
ICGC Data PortalARHGAP1 
TCGA Data PortalARHGAP1 
Broad Tumor PortalARHGAP1
OASIS PortalARHGAP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP1
DgiDB (Drug Gene Interaction Database)ARHGAP1
DoCM (Curated mutations)ARHGAP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP1 (select a term)
intoGenARHGAP1
Cancer3DARHGAP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602732   
Orphanet
DisGeNETARHGAP1
MedgenARHGAP1
Genetic Testing Registry ARHGAP1
NextProtQ07960 [Medical]
TSGene392
GENETestsARHGAP1
Target ValidationARHGAP1
Huge Navigator ARHGAP1 [HugePedia]
snp3D : Map Gene to Disease392
BioCentury BCIQARHGAP1
ClinGenARHGAP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD392
Chemical/Pharm GKB GenePA24956
Clinical trialARHGAP1
Miscellaneous
canSAR (ICR)ARHGAP1 (select the gene name)
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP1
EVEXARHGAP1
GoPubMedARHGAP1
iHOPARHGAP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:03:32 CET 2017

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