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ARHGAP10 (Rho GTPase activating protein 10)

Identity

Alias_symbol (synonym)FLJ20896
FLJ41791
GRAF2
Other aliasPS-GAP
PSGAP
HGNC (Hugo) ARHGAP10
LocusID (NCBI) 79658
Atlas_Id 43130
Location 4q31.23  [Link to chromosome band 4q31]
Location_base_pair Starts at 148653453 and ends at 148993927 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANK2 (4q25) / ARHGAP10 (4q31.23)ARHGAP10 (4q31.23) / CCDC30 (1p34.2)ARHGAP10 (4q31.23) / FBXW2 (9q33.2)
ARHGAP10 (4q31.23) / NR3C2 (4q31.23)ARHGAP10 (4q31.23) / TMEM184C (4q31.23)C9orf85 (9q21.13) / ARHGAP10 (4q31.23)
EHF (11p13) / ARHGAP10 (4q31.23)FBXW7 (4q31.3) / ARHGAP10 (4q31.23)GOLGA3 (12q24.33) / ARHGAP10 (4q31.23)
MAML3 (4q31.1) / ARHGAP10 (4q31.23)SLPI (20q13.12) / ARHGAP10 (4q31.23)TMEM184C (4q31.23) / ARHGAP10 (4q31.23)
ANK2 4q25 / ARHGAP10 4q31.23ARHGAP10 4q31.23 / FBXW2 9q33.2ARHGAP10 4q31.23 / TMEM184C 4q31.23
FBXW7 4q31.3 / ARHGAP10 4q31.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP10   26099
Cards
Entrez_Gene (NCBI)ARHGAP10  79658  Rho GTPase activating protein 10
AliasesGRAF2; PS-GAP; PSGAP
GeneCards (Weizmann)ARHGAP10
Ensembl hg19 (Hinxton)ENSG00000071205 [Gene_View]  chr4:148653453-148993927 [Contig_View]  ARHGAP10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000071205 [Gene_View]  chr4:148653453-148993927 [Contig_View]  ARHGAP10 [Vega]
ICGC DataPortalENSG00000071205
TCGA cBioPortalARHGAP10
AceView (NCBI)ARHGAP10
Genatlas (Paris)ARHGAP10
WikiGenes79658
SOURCE (Princeton)ARHGAP10
Genetics Home Reference (NIH)ARHGAP10
Genomic and cartography
GoldenPath hg19 (UCSC)ARHGAP10  -     chr4:148653453-148993927 +  4q31.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARHGAP10  -     4q31.23   [Description]    (hg38-Dec_2013)
EnsemblARHGAP10 - 4q31.23 [CytoView hg19]  ARHGAP10 - 4q31.23 [CytoView hg38]
Mapping of homologs : NCBIARHGAP10 [Mapview hg19]  ARHGAP10 [Mapview hg38]
OMIM609746   
Gene and transcription
Genbank (Entrez)AB050785 AK024549 AK123034 AK123785 AK130998
RefSeq transcript (Entrez)NM_024605
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)ARHGAP10
Cluster EST : UnigeneHs.368631 [ NCBI ]
CGAP (NCI)Hs.368631
Alternative Splicing GalleryENSG00000071205
Gene ExpressionARHGAP10 [ NCBI-GEO ]   ARHGAP10 [ EBI - ARRAY_EXPRESS ]   ARHGAP10 [ SEEK ]   ARHGAP10 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79658
GTEX Portal (Tissue expression)ARHGAP10
Protein : pattern, domain, 3D structure
UniProt/SwissProtA1A4S6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA1A4S6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA1A4S6
Splice isoforms : SwissVarA1A4S6
PhosPhoSitePlusA1A4S6
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)PH_dom-like    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom    SH3_domain   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00169    pfam00620    pfam14604   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)ARHGAP10
DMDM Disease mutations79658
Blocks (Seattle)ARHGAP10
PDB (SRS)2MIO   
PDB (PDBSum)2MIO   
PDB (IMB)2MIO   
PDB (RSDB)2MIO   
Structural Biology KnowledgeBase2MIO   
SCOP (Structural Classification of Proteins)2MIO   
CATH (Classification of proteins structures)2MIO   
SuperfamilyA1A4S6
Human Protein AtlasENSG00000071205
Peptide AtlasA1A4S6
HPRD07949
IPIIPI00290332   IPI00902714   
Protein Interaction databases
DIP (DOE-UCLA)A1A4S6
IntAct (EBI)A1A4S6
FunCoupENSG00000071205
BioGRIDARHGAP10
STRING (EMBL)ARHGAP10
ZODIACARHGAP10
Ontologies - Pathways
QuickGOA1A4S6
Ontology : AmiGOGTPase activator activity  protein binding  cytosol  plasma membrane  cytoskeleton organization  signal transduction  negative regulation of apoptotic process  positive regulation of GTPase activity  perinuclear region of cytoplasm  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  protein binding  cytosol  plasma membrane  cytoskeleton organization  signal transduction  negative regulation of apoptotic process  positive regulation of GTPase activity  perinuclear region of cytoplasm  regulation of small GTPase mediated signal transduction  
Pathways : KEGGBacterial invasion of epithelial cells   
NDEx NetworkARHGAP10
Atlas of Cancer Signalling NetworkARHGAP10
Wikipedia pathwaysARHGAP10
Orthology - Evolution
OrthoDB79658
GeneTree (enSembl)ENSG00000071205
Phylogenetic Trees/Animal Genes : TreeFamARHGAP10
HOVERGENA1A4S6
HOGENOMA1A4S6
Homologs : HomoloGeneARHGAP10
Homology/Alignments : Family Browser (UCSC)ARHGAP10
Gene fusions - Rearrangements
Fusion : MitelmanANK2/ARHGAP10 [4q25/4q31.23]  [t(4;4)(q25;q31)]  
Fusion : MitelmanARHGAP10/FBXW2 [4q31.23/9q33.2]  [t(4;9)(q31;q33)]  
Fusion : MitelmanARHGAP10/TMEM184C [4q31.23/4q31.23]  [t(4;4)(q31;q31)]  
Fusion : MitelmanFBXW7/ARHGAP10 [4q31.3/4q31.23]  [t(4;4)(q31;q31)]  
Fusion: TCGAANK2 4q25 ARHGAP10 4q31.23 GBM
Fusion: TCGAARHGAP10 4q31.23 FBXW2 9q33.2 PRAD
Fusion: TCGAARHGAP10 4q31.23 TMEM184C 4q31.23 BLCA BRCA
Fusion: TCGAFBXW7 4q31.3 ARHGAP10 4q31.23 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP10
dbVarARHGAP10
ClinVarARHGAP10
1000_GenomesARHGAP10 
Exome Variant ServerARHGAP10
ExAC (Exome Aggregation Consortium)ARHGAP10 (select the gene name)
Genetic variants : HAPMAP79658
Genomic Variants (DGV)ARHGAP10 [DGVbeta]
DECIPHER (Syndromes)4:148653453-148993927  ENSG00000071205
CONAN: Copy Number AnalysisARHGAP10 
Mutations
ICGC Data PortalARHGAP10 
TCGA Data PortalARHGAP10 
Broad Tumor PortalARHGAP10
OASIS PortalARHGAP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP10
DgiDB (Drug Gene Interaction Database)ARHGAP10
DoCM (Curated mutations)ARHGAP10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP10 (select a term)
intoGenARHGAP10
Cancer3DARHGAP10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609746   
Orphanet
MedgenARHGAP10
Genetic Testing Registry ARHGAP10
NextProtA1A4S6 [Medical]
TSGene79658
GENETestsARHGAP10
Huge Navigator ARHGAP10 [HugePedia]
snp3D : Map Gene to Disease79658
BioCentury BCIQARHGAP10
ClinGenARHGAP10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79658
Chemical/Pharm GKB GenePA134904544
Clinical trialARHGAP10
Miscellaneous
canSAR (ICR)ARHGAP10 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP10
EVEXARHGAP10
GoPubMedARHGAP10
iHOPARHGAP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 14:52:51 CEST 2017

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