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ARHGAP12 (Rho GTPase activating protein 12)

Identity

Alias (NCBI)-
HGNC (Hugo) ARHGAP12
HGNC Alias symbFLJ20737
FLJ10971
FLJ21785
LocusID (NCBI) 94134
Atlas_Id 43132
Location 10p11.22  [Link to chromosome band 10p11]
Location_base_pair Starts at 31805398 and ends at 31928831 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP12 (10p11.22) / ARHGAP12 (10p11.22)ARHGAP12 (10p11.22) / DESI1 (22q13.2)ARHGAP12 (10p11.22) / KIF5B (10p11.22)
ARHGAP12 (10p11.22) / SORCS3 (10q25.1)PPIG (2q31.1) / ARHGAP12 (10p11.22)ARHGAP12 10p11.22 PPPDE2
ARHGAP12 10p11.22 / SORCS3 10q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)ARHGAP12   16348
Cards
Entrez_Gene (NCBI)ARHGAP12    Rho GTPase activating protein 12
Aliases
GeneCards (Weizmann)ARHGAP12
Ensembl hg19 (Hinxton)ENSG00000165322 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165322 [Gene_View]  ENSG00000165322 [Sequence]  chr10:31805398-31928831 [Contig_View]  ARHGAP12 [Vega]
ICGC DataPortalENSG00000165322
TCGA cBioPortalARHGAP12
AceView (NCBI)ARHGAP12
Genatlas (Paris)ARHGAP12
SOURCE (Princeton)ARHGAP12
Genetics Home Reference (NIH)ARHGAP12
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP12  -     chr10:31805398-31928831 -  10p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP12  -     10p11.22   [Description]    (hg19-Feb_2009)
GoldenPathARHGAP12 - 10p11.22 [CytoView hg19]  ARHGAP12 - 10p11.22 [CytoView hg38]
ImmunoBaseENSG00000165322
Genome Data Viewer NCBIARHGAP12 [Mapview hg19]  
OMIM610577   
Gene and transcription
Genbank (Entrez)AF131804 AK000744 AK001833 AK025438 AK091182
RefSeq transcript (Entrez)NM_001270695 NM_001270696 NM_001270697 NM_001270698 NM_001270699 NM_018287
Consensus coding sequences : CCDS (NCBI)ARHGAP12
Gene ExpressionARHGAP12 [ NCBI-GEO ]   ARHGAP12 [ EBI - ARRAY_EXPRESS ]   ARHGAP12 [ SEEK ]   ARHGAP12 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP12 [ Firebrowse - Broad ]
GenevisibleExpression of ARHGAP12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)94134
GTEX Portal (Tissue expression)ARHGAP12
Human Protein AtlasENSG00000165322-ARHGAP12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IWW6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IWW6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IWW6
PhosPhoSitePlusQ8IWW6
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)    SH3 (PS50002)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)ARHGAP12_SH3    PH-like_dom_sf    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom    SH3-like_dom_sf    SH3_domain    WW_dom    WW_dom_sf   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00169    pfam00620    pfam14604   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  SH3 (SM00326)  WW (SM00456)  
Conserved Domain (NCBI)ARHGAP12
SuperfamilyQ8IWW6
AlphaFold pdb e-kbQ8IWW6   
Human Protein Atlas [tissue]ENSG00000165322-ARHGAP12 [tissue]
HPRD06446
Protein Interaction databases
DIP (DOE-UCLA)Q8IWW6
IntAct (EBI)Q8IWW6
BioGRIDARHGAP12
STRING (EMBL)ARHGAP12
ZODIACARHGAP12
Ontologies - Pathways
QuickGOQ8IWW6
Ontology : AmiGOphagocytic cup  morphogenesis of an epithelial sheet  GTPase activator activity  cytoplasm  cytosol  phagocytosis, engulfment  actin filament organization  signal transduction  regulation of GTPase activity  regulation of small GTPase mediated signal transduction  negative regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIphagocytic cup  morphogenesis of an epithelial sheet  GTPase activator activity  cytoplasm  cytosol  phagocytosis, engulfment  actin filament organization  signal transduction  regulation of GTPase activity  regulation of small GTPase mediated signal transduction  negative regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGAP12
Atlas of Cancer Signalling NetworkARHGAP12
Wikipedia pathwaysARHGAP12
Orthology - Evolution
OrthoDB94134
GeneTree (enSembl)ENSG00000165322
Phylogenetic Trees/Animal Genes : TreeFamARHGAP12
Homologs : HomoloGeneARHGAP12
Homology/Alignments : Family Browser (UCSC)ARHGAP12
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP12/DESI1 [10p11.22/22q13.2]  
Fusion : MitelmanARHGAP12/SORCS3 [10p11.22/10q25.1]  
Fusion : QuiverARHGAP12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP12
dbVarARHGAP12
ClinVarARHGAP12
MonarchARHGAP12
1000_GenomesARHGAP12 
Exome Variant ServerARHGAP12
GNOMAD BrowserENSG00000165322
Varsome BrowserARHGAP12
ACMGARHGAP12 variants
VarityQ8IWW6
Genomic Variants (DGV)ARHGAP12 [DGVbeta]
DECIPHERARHGAP12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP12 
Mutations
ICGC Data PortalARHGAP12 
TCGA Data PortalARHGAP12 
Broad Tumor PortalARHGAP12
OASIS PortalARHGAP12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARHGAP12
Mutations and Diseases : HGMDARHGAP12
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARHGAP12
DgiDB (Drug Gene Interaction Database)ARHGAP12
DoCM (Curated mutations)ARHGAP12
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP12
Cancer3DARHGAP12
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610577   
Orphanet
DisGeNETARHGAP12
MedgenARHGAP12
Genetic Testing Registry ARHGAP12
NextProtQ8IWW6 [Medical]
GENETestsARHGAP12
Target ValidationARHGAP12
Huge Navigator ARHGAP12 [HugePedia]
ClinGenARHGAP12
Clinical trials, drugs, therapy
MyCancerGenomeARHGAP12
Protein Interactions : CTDARHGAP12
Pharm GKB GenePA24957
PharosQ8IWW6
Clinical trialARHGAP12
Miscellaneous
canSAR (ICR)ARHGAP12
HarmonizomeARHGAP12
DataMed IndexARHGAP12
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARHGAP12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:59:55 CEST 2021
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