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ARHGAP15 (Rho GTPase activating protein 15)

Identity

Alias_symbol (synonym)BM046
Other alias
HGNC (Hugo) ARHGAP15
LocusID (NCBI) 55843
Atlas_Id 43133
Location 2q22.2  [Link to chromosome band 2q22]
Location_base_pair Starts at 143129330 and ends at 143768352 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP15 (2q22.2) / FBXO2 (1p36.22)ARHGAP15 (2q22.2) / INPP5D (2q37.1)ARHGAP15 (2q22.2) / KYNU (2q22.2)
ARHGAP15 (2q22.2) / LILRA6 (19q13.42)ARHGAP15 (2q22.2) / MBNL1 (3q25.1)BCAS3 (17q23.2) / ARHGAP15 (2q22.2)
GBP2 (1p22.2) / ARHGAP15 (2q22.2)PDCD10 (3q26.1) / ARHGAP15 (2q22.2)TMEM182 (2q12.1) / ARHGAP15 (2q22.2)
ARHGAP15 2q22.2 / KYNU 2q22.2TMEM182 2q12.1 / ARHGAP15 2q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP15   21030
Cards
Entrez_Gene (NCBI)ARHGAP15  55843  Rho GTPase activating protein 15
AliasesBM046
GeneCards (Weizmann)ARHGAP15
Ensembl hg19 (Hinxton)ENSG00000075884 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075884 [Gene_View]  chr2:143129330-143768352 [Contig_View]  ARHGAP15 [Vega]
ICGC DataPortalENSG00000075884
TCGA cBioPortalARHGAP15
AceView (NCBI)ARHGAP15
Genatlas (Paris)ARHGAP15
WikiGenes55843
SOURCE (Princeton)ARHGAP15
Genetics Home Reference (NIH)ARHGAP15
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP15  -     chr2:143129330-143768352 +  2q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP15  -     2q22.2   [Description]    (hg19-Feb_2009)
EnsemblARHGAP15 - 2q22.2 [CytoView hg19]  ARHGAP15 - 2q22.2 [CytoView hg38]
Mapping of homologs : NCBIARHGAP15 [Mapview hg19]  ARHGAP15 [Mapview hg38]
OMIM610578   
Gene and transcription
Genbank (Entrez)AF212222 AF217507 AF217522 AK226014 AK303490
RefSeq transcript (Entrez)NM_018460
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP15
Cluster EST : UnigeneHs.171011 [ NCBI ]
CGAP (NCI)Hs.171011
Alternative Splicing GalleryENSG00000075884
Gene ExpressionARHGAP15 [ NCBI-GEO ]   ARHGAP15 [ EBI - ARRAY_EXPRESS ]   ARHGAP15 [ SEEK ]   ARHGAP15 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55843
GTEX Portal (Tissue expression)ARHGAP15
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53QZ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53QZ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53QZ3
Splice isoforms : SwissVarQ53QZ3
PhosPhoSitePlusQ53QZ3
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)   
Domains : Interpro (EBI)PH_dom-like    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00169    pfam00620   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP15
DMDM Disease mutations55843
Blocks (Seattle)ARHGAP15
PDB (SRS)3BYI   
PDB (PDBSum)3BYI   
PDB (IMB)3BYI   
PDB (RSDB)3BYI   
Structural Biology KnowledgeBase3BYI   
SCOP (Structural Classification of Proteins)3BYI   
CATH (Classification of proteins structures)3BYI   
SuperfamilyQ53QZ3
Human Protein AtlasENSG00000075884
Peptide AtlasQ53QZ3
HPRD06447
IPIIPI00182116   IPI00916670   IPI00916850   
Protein Interaction databases
DIP (DOE-UCLA)Q53QZ3
IntAct (EBI)Q53QZ3
FunCoupENSG00000075884
BioGRIDARHGAP15
STRING (EMBL)ARHGAP15
ZODIACARHGAP15
Ontologies - Pathways
QuickGOQ53QZ3
Ontology : AmiGOGTPase activator activity  GTPase activator activity  cytosol  signal transduction  regulation of cell shape  membrane  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  GTPase activator activity  cytosol  signal transduction  regulation of cell shape  membrane  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGAP15
Atlas of Cancer Signalling NetworkARHGAP15
Wikipedia pathwaysARHGAP15
Orthology - Evolution
OrthoDB55843
GeneTree (enSembl)ENSG00000075884
Phylogenetic Trees/Animal Genes : TreeFamARHGAP15
HOVERGENQ53QZ3
HOGENOMQ53QZ3
Homologs : HomoloGeneARHGAP15
Homology/Alignments : Family Browser (UCSC)ARHGAP15
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP15/KYNU [2q22.2/2q22.2]  
Fusion : MitelmanBCAS3/ARHGAP15 [17q23.2/2q22.2]  [t(2;17)(q22;q23)]  
Fusion : MitelmanTMEM182/ARHGAP15 [2q12.1/2q22.2]  [t(2;2)(q12;q22)]  
Fusion: TCGAARHGAP15 2q22.2 KYNU 2q22.2 LUAD
Fusion: TCGATMEM182 2q12.1 ARHGAP15 2q22.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP15
dbVarARHGAP15
ClinVarARHGAP15
1000_GenomesARHGAP15 
Exome Variant ServerARHGAP15
ExAC (Exome Aggregation Consortium)ARHGAP15 (select the gene name)
Genetic variants : HAPMAP55843
Genomic Variants (DGV)ARHGAP15 [DGVbeta]
DECIPHERARHGAP15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP15 
Mutations
ICGC Data PortalARHGAP15 
TCGA Data PortalARHGAP15 
Broad Tumor PortalARHGAP15
OASIS PortalARHGAP15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP15
DgiDB (Drug Gene Interaction Database)ARHGAP15
DoCM (Curated mutations)ARHGAP15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP15 (select a term)
intoGenARHGAP15
Cancer3DARHGAP15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610578   
Orphanet
MedgenARHGAP15
Genetic Testing Registry ARHGAP15
NextProtQ53QZ3 [Medical]
TSGene55843
GENETestsARHGAP15
Huge Navigator ARHGAP15 [HugePedia]
snp3D : Map Gene to Disease55843
BioCentury BCIQARHGAP15
ClinGenARHGAP15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55843
Chemical/Pharm GKB GenePA134938065
Clinical trialARHGAP15
Miscellaneous
canSAR (ICR)ARHGAP15 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP15
EVEXARHGAP15
GoPubMedARHGAP15
iHOPARHGAP15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:06:31 CEST 2017

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