ARHGAP18 (Rho GTPase activating protein 18)

2006-10-01  

Identity

HGNC
LOCATION
6q22.33
LOCUSID
ALIAS
MacGAP,SENEX,bA307O14.2
FUSION GENES

Other Information

Locus ID:

NCBI: 93663
MIM: 613351
HGNC: 21035
Ensembl: ENSG00000146376

Variants:

dbSNP: 93663
ClinVar: 93663
TCGA: ENSG00000146376
COSMIC: ARHGAP18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146376ENST00000368149Q8N392

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
190651462009Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.45
190651462009Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia.45
218655952011ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility.27
206640622010Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells.19
286197082017ARHGAP18 Downregulation by miR-200b Suppresses Metastasis of Triple-Negative Breast Cancer by Enhancing Activation of RhoA.16
189876182009Screening for replication of genome-wide SNP associations in sporadic ALS.14
254251452014ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions.13
282519252017The RhoGAP protein ARHGAP18/SENEX localizes to microtubules and regulates their stability in endothelial cells.7
305101482018LncRNA CDKN2BAS predicts poor prognosis in patients with hepatocellular carcinoma and promotes metastasis via the miR-153-5p/ARHGAP18 signaling axis.6
271769322016The correlation of microRNA-181a and target genes with poor prognosis of glioblastoma patients.4

Citation

Dessen P

ARHGAP18 (Rho GTPase activating protein 18)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43135/arhgap18