Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARHGAP19 (Rho GTPase activating protein 19)

Identity

Alias_symbol (synonym)FLJ00194
MGC14258
Other alias-
HGNC (Hugo) ARHGAP19
LocusID (NCBI) 84986
Atlas_Id 43136
Location 6q22.33  [Link to chromosome band 6q22]
Location_base_pair Starts at 97222173 and ends at 97292673 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP19 (10q24.1) / DRG1 (22q12.2)ARHGAP19 (10q24.1) / RRP12 (10q24.1)ARHGAP19 10q24.1 / RRP12 10q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(3;10)(p21;q24) ARHGAP19/ELP6
ARHGAP19/RRP12 (10q24)
t(10;22)(q24;q12) ARHGAP19/DRG1

External links

Nomenclature
HGNC (Hugo)ARHGAP19   23724
Cards
Entrez_Gene (NCBI)ARHGAP19  84986  Rho GTPase activating protein 19
Aliases
GeneCards (Weizmann)ARHGAP19
Ensembl hg19 (Hinxton)ENSG00000213390 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213390 [Gene_View]  ENSG00000213390 [Sequence]  chr10:97222173-97292673 [Contig_View]  ARHGAP19 [Vega]
ICGC DataPortalENSG00000213390
TCGA cBioPortalARHGAP19
AceView (NCBI)ARHGAP19
Genatlas (Paris)ARHGAP19
WikiGenes84986
SOURCE (Princeton)ARHGAP19
Genetics Home Reference (NIH)ARHGAP19
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP19  -     chr10:97222173-97292673 -  6q22.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP19  -     6q22.33   [Description]    (hg19-Feb_2009)
EnsemblARHGAP19 - 6q22.33 [CytoView hg19]  ARHGAP19 - 6q22.33 [CytoView hg38]
Mapping of homologs : NCBIARHGAP19 [Mapview hg19]  ARHGAP19 [Mapview hg38]
OMIM611587   
Gene and transcription
Genbank (Entrez)AA427792 AK074122 AK090447 AK093316 AK093441
RefSeq transcript (Entrez)NM_001204300 NM_001256423 NM_032900
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP19
Cluster EST : UnigeneHs.80305 [ NCBI ]
CGAP (NCI)Hs.80305
Alternative Splicing GalleryENSG00000213390
Gene ExpressionARHGAP19 [ NCBI-GEO ]   ARHGAP19 [ EBI - ARRAY_EXPRESS ]   ARHGAP19 [ SEEK ]   ARHGAP19 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84986
GTEX Portal (Tissue expression)ARHGAP19
Human Protein AtlasENSG00000213390-ARHGAP19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14CB8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14CB8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14CB8
Splice isoforms : SwissVarQ14CB8
PhosPhoSitePlusQ14CB8
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)   
Domains : Interpro (EBI)Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00620   
Domain families : Smart (EMBL)RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP19
DMDM Disease mutations84986
Blocks (Seattle)ARHGAP19
SuperfamilyQ14CB8
Human Protein Atlas [tissue]ENSG00000213390-ARHGAP19 [tissue]
Peptide AtlasQ14CB8
HPRD12475
IPIIPI00784933   IPI00470885   IPI00514228   IPI00480149   IPI00829662   IPI00793286   IPI00783138   IPI01013017   
Protein Interaction databases
DIP (DOE-UCLA)Q14CB8
IntAct (EBI)Q14CB8
FunCoupENSG00000213390
BioGRIDARHGAP19
STRING (EMBL)ARHGAP19
ZODIACARHGAP19
Ontologies - Pathways
QuickGOQ14CB8
Ontology : AmiGOGTPase activator activity  GTPase activator activity  nucleus  cytoplasm  cytosol  plasma membrane  signal transduction  intracellular membrane-bounded organelle  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  GTPase activator activity  nucleus  cytoplasm  cytosol  plasma membrane  signal transduction  intracellular membrane-bounded organelle  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGAP19
Atlas of Cancer Signalling NetworkARHGAP19
Wikipedia pathwaysARHGAP19
Orthology - Evolution
OrthoDB84986
GeneTree (enSembl)ENSG00000213390
Phylogenetic Trees/Animal Genes : TreeFamARHGAP19
HOVERGENQ14CB8
HOGENOMQ14CB8
Homologs : HomoloGeneARHGAP19
Homology/Alignments : Family Browser (UCSC)ARHGAP19
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP19/DRG1 [10q24.1/22q12.2]  
Fusion : MitelmanARHGAP19/RRP12 [10q24.1/10q24.1]  [t(10;10)(q24;q24)]  
Fusion PortalARHGAP19 10q24.1 RRP12 10q24.1 THCA
Fusion : QuiverARHGAP19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP19
dbVarARHGAP19
ClinVarARHGAP19
1000_GenomesARHGAP19 
Exome Variant ServerARHGAP19
ExAC (Exome Aggregation Consortium)ENSG00000213390
GNOMAD BrowserENSG00000213390
Varsome BrowserARHGAP19
Genetic variants : HAPMAP84986
Genomic Variants (DGV)ARHGAP19 [DGVbeta]
DECIPHERARHGAP19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP19 
Mutations
ICGC Data PortalARHGAP19 
TCGA Data PortalARHGAP19 
Broad Tumor PortalARHGAP19
OASIS PortalARHGAP19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP19
DgiDB (Drug Gene Interaction Database)ARHGAP19
DoCM (Curated mutations)ARHGAP19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP19 (select a term)
intoGenARHGAP19
Cancer3DARHGAP19(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611587   
Orphanet
DisGeNETARHGAP19
MedgenARHGAP19
Genetic Testing Registry ARHGAP19
NextProtQ14CB8 [Medical]
TSGene84986
GENETestsARHGAP19
Target ValidationARHGAP19
Huge Navigator ARHGAP19 [HugePedia]
snp3D : Map Gene to Disease84986
BioCentury BCIQARHGAP19
ClinGenARHGAP19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84986
Chemical/Pharm GKB GenePA134917415
Clinical trialARHGAP19
Miscellaneous
canSAR (ICR)ARHGAP19 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP19
EVEXARHGAP19
GoPubMedARHGAP19
iHOPARHGAP19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Aug 16 10:47:32 CEST 2018
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