Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARHGAP22 (Rho GTPase activating protein 22)

Identity

Alias_symbol (synonym)RhoGAP2
Other aliasRhoGap22
HGNC (Hugo) ARHGAP22
LocusID (NCBI) 58504
Atlas_Id 43138
Location 10q11.22  [Link to chromosome band 10q11]
Location_base_pair Starts at 48446025 and ends at 48605131 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP22 (10q11.22) / AQP1 (7p14.3)MICU1 (10q22.1) / ARHGAP22 (10q11.22)MICU1 10q22.1 / ARHGAP22 10q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(q11;q22) MICU1/ARHGAP22

External links

Nomenclature
HGNC (Hugo)ARHGAP22   30320
Cards
Entrez_Gene (NCBI)ARHGAP22  58504  Rho GTPase activating protein 22
AliasesRhoGAP2; RhoGap22
GeneCards (Weizmann)ARHGAP22
Ensembl hg19 (Hinxton)ENSG00000128805 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128805 [Gene_View]  ENSG00000128805 [Sequence]  chr10:48446025-48605131 [Contig_View]  ARHGAP22 [Vega]
ICGC DataPortalENSG00000128805
TCGA cBioPortalARHGAP22
AceView (NCBI)ARHGAP22
Genatlas (Paris)ARHGAP22
WikiGenes58504
SOURCE (Princeton)ARHGAP22
Genetics Home Reference (NIH)ARHGAP22
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP22  -     chr10:48446025-48605131 -  10q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP22  -     10q11.22   [Description]    (hg19-Feb_2009)
EnsemblARHGAP22 - 10q11.22 [CytoView hg19]  ARHGAP22 - 10q11.22 [CytoView hg38]
Mapping of homologs : NCBIARHGAP22 [Mapview hg19]  ARHGAP22 [Mapview hg38]
OMIM610585   
Gene and transcription
Genbank (Entrez)AK055037 AK055937 AK127586 AK293579 AY324801
RefSeq transcript (Entrez)NM_001256024 NM_001256025 NM_001256026 NM_001256027 NM_001347735 NM_001347736 NM_001347737 NM_001347738 NM_021226
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP22
Cluster EST : UnigeneHs.740750 [ NCBI ]
CGAP (NCI)Hs.740750
Alternative Splicing GalleryENSG00000128805
Gene ExpressionARHGAP22 [ NCBI-GEO ]   ARHGAP22 [ EBI - ARRAY_EXPRESS ]   ARHGAP22 [ SEEK ]   ARHGAP22 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)58504
GTEX Portal (Tissue expression)ARHGAP22
Human Protein AtlasENSG00000128805-ARHGAP22 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z5H3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z5H3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z5H3
Splice isoforms : SwissVarQ7Z5H3
PhosPhoSitePlusQ7Z5H3
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00169    pfam00620   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP22
DMDM Disease mutations58504
Blocks (Seattle)ARHGAP22
SuperfamilyQ7Z5H3
Human Protein Atlas [tissue]ENSG00000128805-ARHGAP22 [tissue]
Peptide AtlasQ7Z5H3
HPRD12476
IPIIPI00644736   IPI00009685   IPI00941482   IPI01015479   IPI00644168   IPI00967309   IPI00964603   IPI00829760   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z5H3
IntAct (EBI)Q7Z5H3
FunCoupENSG00000128805
BioGRIDARHGAP22
STRING (EMBL)ARHGAP22
ZODIACARHGAP22
Ontologies - Pathways
QuickGOQ7Z5H3
Ontology : AmiGOangiogenesis  GTPase activator activity  protein binding  nucleus  cytosol  focal adhesion  signal transduction  cell differentiation  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  glutamatergic synapse  glutamatergic synapse  regulation of postsynapse organization  regulation of postsynapse organization  
Ontology : EGO-EBIangiogenesis  GTPase activator activity  protein binding  nucleus  cytosol  focal adhesion  signal transduction  cell differentiation  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  glutamatergic synapse  glutamatergic synapse  regulation of postsynapse organization  regulation of postsynapse organization  
NDEx NetworkARHGAP22
Atlas of Cancer Signalling NetworkARHGAP22
Wikipedia pathwaysARHGAP22
Orthology - Evolution
OrthoDB58504
GeneTree (enSembl)ENSG00000128805
Phylogenetic Trees/Animal Genes : TreeFamARHGAP22
HOVERGENQ7Z5H3
HOGENOMQ7Z5H3
Homologs : HomoloGeneARHGAP22
Homology/Alignments : Family Browser (UCSC)ARHGAP22
Gene fusions - Rearrangements
Fusion : MitelmanMICU1/ARHGAP22 [10q22.1/10q11.22]  [t(10;10)(q11;q22)]  
Fusion PortalMICU1 10q22.1 ARHGAP22 10q11.22 BRCA
Fusion : QuiverARHGAP22
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP22
dbVarARHGAP22
ClinVarARHGAP22
1000_GenomesARHGAP22 
Exome Variant ServerARHGAP22
ExAC (Exome Aggregation Consortium)ENSG00000128805
GNOMAD BrowserENSG00000128805
Varsome BrowserARHGAP22
Genetic variants : HAPMAP58504
Genomic Variants (DGV)ARHGAP22 [DGVbeta]
DECIPHERARHGAP22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP22 
Mutations
ICGC Data PortalARHGAP22 
TCGA Data PortalARHGAP22 
Broad Tumor PortalARHGAP22
OASIS PortalARHGAP22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP22  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP22
DgiDB (Drug Gene Interaction Database)ARHGAP22
DoCM (Curated mutations)ARHGAP22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP22 (select a term)
intoGenARHGAP22
Cancer3DARHGAP22(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610585   
Orphanet
DisGeNETARHGAP22
MedgenARHGAP22
Genetic Testing Registry ARHGAP22
NextProtQ7Z5H3 [Medical]
TSGene58504
GENETestsARHGAP22
Target ValidationARHGAP22
Huge Navigator ARHGAP22 [HugePedia]
snp3D : Map Gene to Disease58504
BioCentury BCIQARHGAP22
ClinGenARHGAP22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD58504
Chemical/Pharm GKB GenePA134979724
Clinical trialARHGAP22
Miscellaneous
canSAR (ICR)ARHGAP22 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP22
EVEXARHGAP22
GoPubMedARHGAP22
iHOPARHGAP22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 10:52:03 CET 2018
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