Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARHGAP24 (Rho GTPase activating protein 24)

Identity

Alias_symbol (synonym)DKFZP564B1162
FLJ33877
FilGAP
Other aliasFILGAP
RC-GAP72
RCGAP72
p73
p73RhoGAP
HGNC (Hugo) ARHGAP24
LocusID (NCBI) 83478
Atlas_Id 695
Location 4q21.23  [Link to chromosome band 4q21]
Location_base_pair Starts at 85930273 and ends at 86002670 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP24 (4q21.23) / ARHGAP24 (4q21.23)ARHGAP24 (4q21.23) / BANK1 (4q24)ARHGAP24 (4q21.23) / NENF (1q32.3)
ARHGAP24 (4q21.23) / NOA1 (4q12)FGD6 (12q22) / ARHGAP24 (4q21.23)ARHGAP24 4q21.23 C4orf14

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;4)(q12;q21) ARHGAP24/NOA1

External links

Nomenclature
HGNC (Hugo)ARHGAP24   25361
Cards
Entrez_Gene (NCBI)ARHGAP24  83478  Rho GTPase activating protein 24
AliasesFILGAP; RC-GAP72; RCGAP72; p73; 
p73RhoGAP
GeneCards (Weizmann)ARHGAP24
Ensembl hg19 (Hinxton)ENSG00000138639 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138639 [Gene_View]  ENSG00000138639 [Sequence]  chr4:85930273-86002670 [Contig_View]  ARHGAP24 [Vega]
ICGC DataPortalENSG00000138639
TCGA cBioPortalARHGAP24
AceView (NCBI)ARHGAP24
Genatlas (Paris)ARHGAP24
WikiGenes83478
SOURCE (Princeton)ARHGAP24
Genetics Home Reference (NIH)ARHGAP24
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP24  -     chr4:85930273-86002670 +  4q21.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP24  -     4q21.23   [Description]    (hg19-Feb_2009)
EnsemblARHGAP24 - 4q21.23 [CytoView hg19]  ARHGAP24 - 4q21.23 [CytoView hg38]
Mapping of homologs : NCBIARHGAP24 [Mapview hg19]  ARHGAP24 [Mapview hg38]
OMIM610586   
Gene and transcription
Genbank (Entrez)AK055572 AK091196 AK098193 AK129988 AK130576
RefSeq transcript (Entrez)NM_001025616 NM_001042669 NM_001287805 NM_001346093 NM_031305
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP24
Cluster EST : UnigeneHs.689398 [ NCBI ]
CGAP (NCI)Hs.689398
Alternative Splicing GalleryENSG00000138639
Gene ExpressionARHGAP24 [ NCBI-GEO ]   ARHGAP24 [ EBI - ARRAY_EXPRESS ]   ARHGAP24 [ SEEK ]   ARHGAP24 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP24 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83478
GTEX Portal (Tissue expression)ARHGAP24
Human Protein AtlasENSG00000138639-ARHGAP24 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N264   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N264  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N264
Splice isoforms : SwissVarQ8N264
PhosPhoSitePlusQ8N264
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00169    pfam00620   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP24
DMDM Disease mutations83478
Blocks (Seattle)ARHGAP24
SuperfamilyQ8N264
Human Protein Atlas [tissue]ENSG00000138639-ARHGAP24 [tissue]
Peptide AtlasQ8N264
HPRD09804
IPIIPI00166301   IPI00010448   IPI00783816   IPI00829821   IPI00442526   IPI01009913   IPI00967419   IPI00966561   IPI00964885   
Protein Interaction databases
DIP (DOE-UCLA)Q8N264
IntAct (EBI)Q8N264
FunCoupENSG00000138639
BioGRIDARHGAP24
STRING (EMBL)ARHGAP24
ZODIACARHGAP24
Ontologies - Pathways
QuickGOQ8N264
Ontology : AmiGOangiogenesis  GTPase activator activity  protein binding  cytosol  cytoskeleton  focal adhesion  signal transduction  cell differentiation  cell projection  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIangiogenesis  GTPase activator activity  protein binding  cytosol  cytoskeleton  focal adhesion  signal transduction  cell differentiation  cell projection  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGAP24
Atlas of Cancer Signalling NetworkARHGAP24
Wikipedia pathwaysARHGAP24
Orthology - Evolution
OrthoDB83478
GeneTree (enSembl)ENSG00000138639
Phylogenetic Trees/Animal Genes : TreeFamARHGAP24
HOVERGENQ8N264
HOGENOMQ8N264
Homologs : HomoloGeneARHGAP24
Homology/Alignments : Family Browser (UCSC)ARHGAP24
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP24/NOA1 [4q21.23/4q12]  
Fusion PortalARHGAP24 4q21.23 C4orf14 BRCA
Fusion : QuiverARHGAP24
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP24 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP24
dbVarARHGAP24
ClinVarARHGAP24
1000_GenomesARHGAP24 
Exome Variant ServerARHGAP24
ExAC (Exome Aggregation Consortium)ENSG00000138639
GNOMAD BrowserENSG00000138639
Varsome BrowserARHGAP24
Genetic variants : HAPMAP83478
Genomic Variants (DGV)ARHGAP24 [DGVbeta]
DECIPHERARHGAP24 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP24 
Mutations
ICGC Data PortalARHGAP24 
TCGA Data PortalARHGAP24 
Broad Tumor PortalARHGAP24
OASIS PortalARHGAP24 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP24  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP24
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP24
DgiDB (Drug Gene Interaction Database)ARHGAP24
DoCM (Curated mutations)ARHGAP24 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP24 (select a term)
intoGenARHGAP24
Cancer3DARHGAP24(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610586   
Orphanet12191   
DisGeNETARHGAP24
MedgenARHGAP24
Genetic Testing Registry ARHGAP24
NextProtQ8N264 [Medical]
TSGene83478
GENETestsARHGAP24
Target ValidationARHGAP24
Huge Navigator ARHGAP24 [HugePedia]
snp3D : Map Gene to Disease83478
BioCentury BCIQARHGAP24
ClinGenARHGAP24
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83478
Chemical/Pharm GKB GenePA134934054
Clinical trialARHGAP24
Miscellaneous
canSAR (ICR)ARHGAP24 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP24
EVEXARHGAP24
GoPubMedARHGAP24
iHOPARHGAP24
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:09:48 CEST 2018
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