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ARHGAP25 (Rho GTPase activating protein 25)

Identity

Alias (NCBI)HEL-S-308
KAIA0053
HGNC (Hugo) ARHGAP25
HGNC Alias symbKIAA0053
LocusID (NCBI) 9938
Atlas_Id 43140
Location 2p13.3  [Link to chromosome band 2p13]
Location_base_pair Starts at 68774910 and ends at 68826825 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MBOAT2 (2p25.1) / ARHGAP25 (2p13.3)MBOAT2 2p25.1 / ARHGAP25 2p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ARHGAP25   28951
Cards
Entrez_Gene (NCBI)ARHGAP25    Rho GTPase activating protein 25
AliasesHEL-S-308; KAIA0053
GeneCards (Weizmann)ARHGAP25
Ensembl hg19 (Hinxton)ENSG00000163219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163219 [Gene_View]  ENSG00000163219 [Sequence]  chr2:68774910-68826825 [Contig_View]  ARHGAP25 [Vega]
ICGC DataPortalENSG00000163219
TCGA cBioPortalARHGAP25
AceView (NCBI)ARHGAP25
Genatlas (Paris)ARHGAP25
SOURCE (Princeton)ARHGAP25
Genetics Home Reference (NIH)ARHGAP25
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP25  -     chr2:68774910-68826825 +  2p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP25  -     2p13.3   [Description]    (hg19-Feb_2009)
GoldenPathARHGAP25 - 2p13.3 [CytoView hg19]  ARHGAP25 - 2p13.3 [CytoView hg38]
ImmunoBaseENSG00000163219
Genome Data Viewer NCBIARHGAP25 [Mapview hg19]  
OMIM610587   
Gene and transcription
Genbank (Entrez)AK290396 AK297056 AK297157 AK298669 AK303591
RefSeq transcript (Entrez)NM_001007231 NM_001166276 NM_001166277 NM_001364819 NM_001364820 NM_001364821 NM_014882
Consensus coding sequences : CCDS (NCBI)ARHGAP25
Gene ExpressionARHGAP25 [ NCBI-GEO ]   ARHGAP25 [ EBI - ARRAY_EXPRESS ]   ARHGAP25 [ SEEK ]   ARHGAP25 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP25 [ Firebrowse - Broad ]
GenevisibleExpression of ARHGAP25 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9938
GTEX Portal (Tissue expression)ARHGAP25
Human Protein AtlasENSG00000163219-ARHGAP25 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42331   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42331  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42331
PhosPhoSitePlusP42331
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)   
Domains : Interpro (EBI)PH-like_dom_sf    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00169    pfam00620   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP25
PDB (RSDB)1V89   
PDB Europe1V89   
PDB (PDBSum)1V89   
PDB (IMB)1V89   
Structural Biology KnowledgeBase1V89   
SCOP (Structural Classification of Proteins)1V89   
CATH (Classification of proteins structures)1V89   
SuperfamilyP42331
AlphaFold pdb e-kbP42331   
Human Protein Atlas [tissue]ENSG00000163219-ARHGAP25 [tissue]
HPRD09805
Protein Interaction databases
DIP (DOE-UCLA)P42331
IntAct (EBI)P42331
BioGRIDARHGAP25
STRING (EMBL)ARHGAP25
ZODIACARHGAP25
Ontologies - Pathways
QuickGOP42331
Ontology : AmiGOphagocytic cup  phagocytic cup  GTPase activator activity  cytosol  phagocytosis, engulfment  phagocytosis, engulfment  actin filament organization  actin filament organization  signal transduction  regulation of small GTPase mediated signal transduction  negative regulation of small GTPase mediated signal transduction  negative regulation of small GTPase mediated signal transduction  activation of GTPase activity  
Ontology : EGO-EBIphagocytic cup  phagocytic cup  GTPase activator activity  cytosol  phagocytosis, engulfment  phagocytosis, engulfment  actin filament organization  actin filament organization  signal transduction  regulation of small GTPase mediated signal transduction  negative regulation of small GTPase mediated signal transduction  negative regulation of small GTPase mediated signal transduction  activation of GTPase activity  
NDEx NetworkARHGAP25
Atlas of Cancer Signalling NetworkARHGAP25
Wikipedia pathwaysARHGAP25
Orthology - Evolution
OrthoDB9938
GeneTree (enSembl)ENSG00000163219
Phylogenetic Trees/Animal Genes : TreeFamARHGAP25
Homologs : HomoloGeneARHGAP25
Homology/Alignments : Family Browser (UCSC)ARHGAP25
Gene fusions - Rearrangements
Fusion : MitelmanMBOAT2/ARHGAP25 [2p25.1/2p13.3]  
Fusion : QuiverARHGAP25
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP25
dbVarARHGAP25
ClinVarARHGAP25
MonarchARHGAP25
1000_GenomesARHGAP25 
Exome Variant ServerARHGAP25
GNOMAD BrowserENSG00000163219
Varsome BrowserARHGAP25
ACMGARHGAP25 variants
VarityP42331
Genomic Variants (DGV)ARHGAP25 [DGVbeta]
DECIPHERARHGAP25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP25 
Mutations
ICGC Data PortalARHGAP25 
TCGA Data PortalARHGAP25 
Broad Tumor PortalARHGAP25
OASIS PortalARHGAP25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP25  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARHGAP25
Mutations and Diseases : HGMDARHGAP25
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARHGAP25
DgiDB (Drug Gene Interaction Database)ARHGAP25
DoCM (Curated mutations)ARHGAP25
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP25
Cancer3DARHGAP25
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610587   
Orphanet
DisGeNETARHGAP25
MedgenARHGAP25
Genetic Testing Registry ARHGAP25
NextProtP42331 [Medical]
GENETestsARHGAP25
Target ValidationARHGAP25
Huge Navigator ARHGAP25 [HugePedia]
ClinGenARHGAP25
Clinical trials, drugs, therapy
MyCancerGenomeARHGAP25
Protein Interactions : CTDARHGAP25
Pharm GKB GenePA134941737
PharosP42331
Clinical trialARHGAP25
Miscellaneous
canSAR (ICR)ARHGAP25
HarmonizomeARHGAP25
DataMed IndexARHGAP25
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARHGAP25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 14:59:57 CEST 2021

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