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ARHGAP25 (Rho GTPase activating protein 25)

Identity

Alias_symbol (synonym)KIAA0053
Other aliasHEL-S-308
KAIA0053
HGNC (Hugo) ARHGAP25
LocusID (NCBI) 9938
Atlas_Id 43140
Location 2p13.3  [Link to chromosome band 2p13]
Location_base_pair Starts at 68734781 and ends at 68826825 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MBOAT2 (2p25.1) / ARHGAP25 (2p13.3)MBOAT2 2p25.1 / ARHGAP25 2p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP25   28951
Cards
Entrez_Gene (NCBI)ARHGAP25  9938  Rho GTPase activating protein 25
AliasesHEL-S-308; KAIA0053
GeneCards (Weizmann)ARHGAP25
Ensembl hg19 (Hinxton)ENSG00000163219 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163219 [Gene_View]  chr2:68734781-68826825 [Contig_View]  ARHGAP25 [Vega]
ICGC DataPortalENSG00000163219
TCGA cBioPortalARHGAP25
AceView (NCBI)ARHGAP25
Genatlas (Paris)ARHGAP25
WikiGenes9938
SOURCE (Princeton)ARHGAP25
Genetics Home Reference (NIH)ARHGAP25
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP25  -     chr2:68734781-68826825 +  2p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP25  -     2p13.3   [Description]    (hg19-Feb_2009)
EnsemblARHGAP25 - 2p13.3 [CytoView hg19]  ARHGAP25 - 2p13.3 [CytoView hg38]
Mapping of homologs : NCBIARHGAP25 [Mapview hg19]  ARHGAP25 [Mapview hg38]
OMIM610587   
Gene and transcription
Genbank (Entrez)AK290396 AK297056 AK297157 AK298669 AK303591
RefSeq transcript (Entrez)NM_001007231 NM_001166276 NM_001166277 NM_014882
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP25
Cluster EST : UnigeneHs.531807 [ NCBI ]
CGAP (NCI)Hs.531807
Alternative Splicing GalleryENSG00000163219
Gene ExpressionARHGAP25 [ NCBI-GEO ]   ARHGAP25 [ EBI - ARRAY_EXPRESS ]   ARHGAP25 [ SEEK ]   ARHGAP25 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9938
GTEX Portal (Tissue expression)ARHGAP25
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42331   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42331  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42331
Splice isoforms : SwissVarP42331
PhosPhoSitePlusP42331
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)   
Domains : Interpro (EBI)PH_dom-like    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00169    pfam00620   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP25
DMDM Disease mutations9938
Blocks (Seattle)ARHGAP25
PDB (SRS)1V89   
PDB (PDBSum)1V89   
PDB (IMB)1V89   
PDB (RSDB)1V89   
Structural Biology KnowledgeBase1V89   
SCOP (Structural Classification of Proteins)1V89   
CATH (Classification of proteins structures)1V89   
SuperfamilyP42331
Human Protein AtlasENSG00000163219
Peptide AtlasP42331
HPRD09805
IPIIPI00400909   IPI00383530   IPI00930670   IPI00479720   IPI00944931   IPI00915867   IPI00946781   IPI00946052   IPI00945074   IPI00945893   IPI00922736   
Protein Interaction databases
DIP (DOE-UCLA)P42331
IntAct (EBI)P42331
FunCoupENSG00000163219
BioGRIDARHGAP25
STRING (EMBL)ARHGAP25
ZODIACARHGAP25
Ontologies - Pathways
QuickGOP42331
Ontology : AmiGOGTPase activator activity  cytosol  signal transduction  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  cytosol  signal transduction  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGAP25
Atlas of Cancer Signalling NetworkARHGAP25
Wikipedia pathwaysARHGAP25
Orthology - Evolution
OrthoDB9938
GeneTree (enSembl)ENSG00000163219
Phylogenetic Trees/Animal Genes : TreeFamARHGAP25
HOVERGENP42331
HOGENOMP42331
Homologs : HomoloGeneARHGAP25
Homology/Alignments : Family Browser (UCSC)ARHGAP25
Gene fusions - Rearrangements
Fusion : MitelmanMBOAT2/ARHGAP25 [2p25.1/2p13.3]  [t(2;2)(p13;p25)]  
Fusion: TCGAMBOAT2 2p25.1 ARHGAP25 2p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP25
dbVarARHGAP25
ClinVarARHGAP25
1000_GenomesARHGAP25 
Exome Variant ServerARHGAP25
ExAC (Exome Aggregation Consortium)ARHGAP25 (select the gene name)
Genetic variants : HAPMAP9938
Genomic Variants (DGV)ARHGAP25 [DGVbeta]
DECIPHERARHGAP25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP25 
Mutations
ICGC Data PortalARHGAP25 
TCGA Data PortalARHGAP25 
Broad Tumor PortalARHGAP25
OASIS PortalARHGAP25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP25
DgiDB (Drug Gene Interaction Database)ARHGAP25
DoCM (Curated mutations)ARHGAP25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP25 (select a term)
intoGenARHGAP25
Cancer3DARHGAP25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610587   
Orphanet
MedgenARHGAP25
Genetic Testing Registry ARHGAP25
NextProtP42331 [Medical]
TSGene9938
GENETestsARHGAP25
Huge Navigator ARHGAP25 [HugePedia]
snp3D : Map Gene to Disease9938
BioCentury BCIQARHGAP25
ClinGenARHGAP25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9938
Chemical/Pharm GKB GenePA134941737
Clinical trialARHGAP25
Miscellaneous
canSAR (ICR)ARHGAP25 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP25
EVEXARHGAP25
GoPubMedARHGAP25
iHOPARHGAP25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:06:32 CEST 2017

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