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ARHGAP32 (Rho GTPase activating protein 32)

Identity

Alias_symbol (synonym)GRIT
KIAA0712
MGC1892
RICS
GC-GAP
Other aliasPX-RICS
p200RhoGAP
p250GAP
HGNC (Hugo) ARHGAP32
LocusID (NCBI) 9743
Atlas_Id 43468
Location 11q24.3  [Link to chromosome band 11q24]
Location_base_pair Starts at 128965060 and ends at 129192198 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP32 (11q24.3) / AHNAK (11q12.3)ARHGAP32 (11q24.3) / C20orf24 (20q11.23)ARHGAP32 (11q24.3) / CAPRIN1 (11p13)
ARHGAP32 (11q24.3) / CWF19L2 (11q22.3)ARHGAP32 (11q24.3) / DONSON (21q22.11)ARHGAP32 (11q24.3) / EPB41L2 (6q23.1)
ARHGAP32 (11q24.3) / FCHSD2 (11q13.4)ARHGAP32 (11q24.3) / LARP4 (12q13.12)HSP90AA1 (14q32.31) / ARHGAP32 (11q24.3)
YWHAB (20q13.12) / ARHGAP32 (11q24.3)ARHGAP32 11q24.3 / AHNAK 11q12.3ARHGAP32 11q24.3 / C20orf24 20q11.23
ARHGAP32 11q24.3 / CWF19L2 11q22.3ARHGAP32 11q24.3 / FCHSD2 11q13.4YWHAB 20q13.12 / ARHGAP32 11q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP32   17399
Cards
Entrez_Gene (NCBI)ARHGAP32  9743  Rho GTPase activating protein 32
AliasesGC-GAP; GRIT; PX-RICS; RICS; 
p200RhoGAP; p250GAP
GeneCards (Weizmann)ARHGAP32
Ensembl hg19 (Hinxton)ENSG00000134909 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134909 [Gene_View]  chr11:128965060-129192198 [Contig_View]  ARHGAP32 [Vega]
ICGC DataPortalENSG00000134909
TCGA cBioPortalARHGAP32
AceView (NCBI)ARHGAP32
Genatlas (Paris)ARHGAP32
WikiGenes9743
SOURCE (Princeton)ARHGAP32
Genetics Home Reference (NIH)ARHGAP32
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP32  -     chr11:128965060-129192198 -  11q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP32  -     11q24.3   [Description]    (hg19-Feb_2009)
EnsemblARHGAP32 - 11q24.3 [CytoView hg19]  ARHGAP32 - 11q24.3 [CytoView hg38]
Mapping of homologs : NCBIARHGAP32 [Mapview hg19]  ARHGAP32 [Mapview hg38]
OMIM608541   
Gene and transcription
Genbank (Entrez)AB018255 AB079856 AB088416 AK001257 AK023715
RefSeq transcript (Entrez)NM_001142685 NM_014715
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP32
Cluster EST : UnigeneHs.440379 [ NCBI ]
CGAP (NCI)Hs.440379
Alternative Splicing GalleryENSG00000134909
Gene ExpressionARHGAP32 [ NCBI-GEO ]   ARHGAP32 [ EBI - ARRAY_EXPRESS ]   ARHGAP32 [ SEEK ]   ARHGAP32 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP32 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9743
GTEX Portal (Tissue expression)ARHGAP32
Protein : pattern, domain, 3D structure
UniProt/SwissProtA7KAX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA7KAX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA7KAX9
Splice isoforms : SwissVarA7KAX9
PhosPhoSitePlusA7KAX9
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)Phox    Rho_GTPase_activation_prot    RhoGAP_dom    SH3_domain   
Domain families : Pfam (Sanger)PX (PF00787)    RhoGAP (PF00620)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00787    pfam00620    pfam14604   
Domain families : Smart (EMBL)RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)ARHGAP32
DMDM Disease mutations9743
Blocks (Seattle)ARHGAP32
PDB (SRS)3IUG   
PDB (PDBSum)3IUG   
PDB (IMB)3IUG   
PDB (RSDB)3IUG   
Structural Biology KnowledgeBase3IUG   
SCOP (Structural Classification of Proteins)3IUG   
CATH (Classification of proteins structures)3IUG   
SuperfamilyA7KAX9
Human Protein AtlasENSG00000134909
Peptide AtlasA7KAX9
HPRD12257
IPIIPI00787743   IPI00900354   IPI01018779   IPI00953595   IPI00982807   IPI00975858   
Protein Interaction databases
DIP (DOE-UCLA)A7KAX9
IntAct (EBI)A7KAX9
FunCoupENSG00000134909
BioGRIDARHGAP32
STRING (EMBL)ARHGAP32
ZODIACARHGAP32
Ontologies - Pathways
QuickGOA7KAX9
Ontology : AmiGOGolgi membrane  fibrillar center  GTPase activator activity  GTPase activator activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  Golgi apparatus  cytosol  cell cortex  small GTPase mediated signal transduction  endosome membrane  postsynaptic density  actin cytoskeleton  cell junction  phosphatidylinositol binding  dendritic spine  positive regulation of GTPase activity  postsynaptic membrane  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGolgi membrane  fibrillar center  GTPase activator activity  GTPase activator activity  protein binding  nucleoplasm  endoplasmic reticulum membrane  Golgi apparatus  cytosol  cell cortex  small GTPase mediated signal transduction  endosome membrane  postsynaptic density  actin cytoskeleton  cell junction  phosphatidylinositol binding  dendritic spine  positive regulation of GTPase activity  postsynaptic membrane  regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGAP32
Atlas of Cancer Signalling NetworkARHGAP32
Wikipedia pathwaysARHGAP32
Orthology - Evolution
OrthoDB9743
GeneTree (enSembl)ENSG00000134909
Phylogenetic Trees/Animal Genes : TreeFamARHGAP32
HOVERGENA7KAX9
HOGENOMA7KAX9
Homologs : HomoloGeneARHGAP32
Homology/Alignments : Family Browser (UCSC)ARHGAP32
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP32/AHNAK [11q24.3/11q12.3]  
Fusion : MitelmanARHGAP32/C20orf24 [11q24.3/20q11.23]  [t(11;20)(q24;q11)]  
Fusion : MitelmanARHGAP32/CWF19L2 [11q24.3/11q22.3]  [t(11;11)(q22;q24)]  
Fusion : MitelmanARHGAP32/FCHSD2 [11q24.3/11q13.4]  [t(11;11)(q13;q24)]  
Fusion : MitelmanYWHAB/ARHGAP32 [20q13.12/11q24.3]  [t(11;20)(q24;q13)]  
Fusion: TCGAARHGAP32 11q24.3 AHNAK 11q12.3 BRCA
Fusion: TCGAARHGAP32 11q24.3 C20orf24 20q11.23 BRCA
Fusion: TCGAARHGAP32 11q24.3 CWF19L2 11q22.3 PRAD
Fusion: TCGAARHGAP32 11q24.3 FCHSD2 11q13.4 BRCA
Fusion: TCGAYWHAB 20q13.12 ARHGAP32 11q24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP32 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP32
dbVarARHGAP32
ClinVarARHGAP32
1000_GenomesARHGAP32 
Exome Variant ServerARHGAP32
ExAC (Exome Aggregation Consortium)ARHGAP32 (select the gene name)
Genetic variants : HAPMAP9743
Genomic Variants (DGV)ARHGAP32 [DGVbeta]
DECIPHERARHGAP32 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP32 
Mutations
ICGC Data PortalARHGAP32 
TCGA Data PortalARHGAP32 
Broad Tumor PortalARHGAP32
OASIS PortalARHGAP32 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP32  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP32
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP32
DgiDB (Drug Gene Interaction Database)ARHGAP32
DoCM (Curated mutations)ARHGAP32 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP32 (select a term)
intoGenARHGAP32
Cancer3DARHGAP32(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608541   
Orphanet
MedgenARHGAP32
Genetic Testing Registry ARHGAP32
NextProtA7KAX9 [Medical]
TSGene9743
GENETestsARHGAP32
Target ValidationARHGAP32
Huge Navigator ARHGAP32 [HugePedia]
snp3D : Map Gene to Disease9743
BioCentury BCIQARHGAP32
ClinGenARHGAP32
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9743
Chemical/Pharm GKB GenePA165543138
Clinical trialARHGAP32
Miscellaneous
canSAR (ICR)ARHGAP32 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP32
EVEXARHGAP32
GoPubMedARHGAP32
iHOPARHGAP32
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:47:09 CEST 2017

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