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ARHGAP32 (Rho GTPase activating protein 32)

Identity

Alias (NCBI)GC-GAP
GRIT
PX-RICS
RICS
p200RhoGAP
p250GAP
HGNC (Hugo) ARHGAP32
HGNC Alias symbGRIT
KIAA0712
MGC1892
RICS
GC-GAP
LocusID (NCBI) 9743
Atlas_Id 43468
Location 11q24.3  [Link to chromosome band 11q24]
Location_base_pair Starts at 128965060 and ends at 129024188 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP32 (11q24.3) / AHNAK (11q12.3)ARHGAP32 (11q24.3) / C20orf24 (20q11.23)ARHGAP32 (11q24.3) / CAPRIN1 (11p13)
ARHGAP32 (11q24.3) / CWF19L2 (11q22.3)ARHGAP32 (11q24.3) / DONSON (21q22.11)ARHGAP32 (11q24.3) / EPB41L2 (6q23.1)
ARHGAP32 (11q24.3) / FCHSD2 (11q13.4)ARHGAP32 (11q24.3) / LARP4 (12q13.12)HSP90AA1 (14q32.31) / ARHGAP32 (11q24.3)
YWHAB (20q13.12) / ARHGAP32 (11q24.3)ARHGAP32 11q24.3 / AHNAK 11q12.3ARHGAP32 11q24.3 / C20orf24 20q11.23
ARHGAP32 11q24.3 / CWF19L2 11q22.3ARHGAP32 11q24.3 / FCHSD2 11q13.4YWHAB 20q13.12 / ARHGAP32 11q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(p13;q24) ARHGAP32/CAPRIN1


External links

 

Nomenclature
HGNC (Hugo)ARHGAP32   17399
Cards
Entrez_Gene (NCBI)ARHGAP32    Rho GTPase activating protein 32
AliasesGC-GAP; GRIT; PX-RICS; RICS; 
p200RhoGAP; p250GAP
GeneCards (Weizmann)ARHGAP32
Ensembl hg19 (Hinxton)ENSG00000134909 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134909 [Gene_View]  ENSG00000134909 [Sequence]  chr11:128965060-129024188 [Contig_View]  ARHGAP32 [Vega]
ICGC DataPortalENSG00000134909
TCGA cBioPortalARHGAP32
AceView (NCBI)ARHGAP32
Genatlas (Paris)ARHGAP32
SOURCE (Princeton)ARHGAP32
Genetics Home Reference (NIH)ARHGAP32
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP32  -     chr11:128965060-129024188 -  11q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP32  -     11q24.3   [Description]    (hg19-Feb_2009)
GoldenPathARHGAP32 - 11q24.3 [CytoView hg19]  ARHGAP32 - 11q24.3 [CytoView hg38]
ImmunoBaseENSG00000134909
Genome Data Viewer NCBIARHGAP32 [Mapview hg19]  
OMIM608541   
Gene and transcription
Genbank (Entrez)AB018255 AB079856 AB088416 AK001257 AK023715
RefSeq transcript (Entrez)NM_001142685 NM_001378024 NM_001378025 NM_014715
Consensus coding sequences : CCDS (NCBI)ARHGAP32
Gene ExpressionARHGAP32 [ NCBI-GEO ]   ARHGAP32 [ EBI - ARRAY_EXPRESS ]   ARHGAP32 [ SEEK ]   ARHGAP32 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP32 [ Firebrowse - Broad ]
GenevisibleExpression of ARHGAP32 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9743
GTEX Portal (Tissue expression)ARHGAP32
Human Protein AtlasENSG00000134909-ARHGAP32 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA7KAX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA7KAX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA7KAX9
PhosPhoSitePlusA7KAX9
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)PX_ARHGAP32    PX_dom_sf    Rho_GTPase_activation_prot    RhoGAP_dom    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)RhoGAP (PF00620)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00620    pfam14604   
Domain families : Smart (EMBL)RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)ARHGAP32
PDB (RSDB)3IUG   
PDB Europe3IUG   
PDB (PDBSum)3IUG   
PDB (IMB)3IUG   
Structural Biology KnowledgeBase3IUG   
SCOP (Structural Classification of Proteins)3IUG   
CATH (Classification of proteins structures)3IUG   
SuperfamilyA7KAX9
AlphaFold pdb e-kbA7KAX9   
Human Protein Atlas [tissue]ENSG00000134909-ARHGAP32 [tissue]
HPRD12257
Protein Interaction databases
DIP (DOE-UCLA)A7KAX9
IntAct (EBI)A7KAX9
BioGRIDARHGAP32
STRING (EMBL)ARHGAP32
ZODIACARHGAP32
Ontologies - Pathways
QuickGOA7KAX9
Ontology : AmiGOGolgi membrane  fibrillar center  fibrillar center  GTPase activator activity  protein binding  nucleoplasm  nucleoplasm  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  cytosol  cell cortex  small GTPase mediated signal transduction  endosome membrane  postsynaptic density  actin cytoskeleton  dendritic spine  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  phosphatidylinositol phosphate binding  
Ontology : EGO-EBIGolgi membrane  fibrillar center  fibrillar center  GTPase activator activity  protein binding  nucleoplasm  nucleoplasm  endoplasmic reticulum membrane  Golgi apparatus  Golgi apparatus  cytosol  cell cortex  small GTPase mediated signal transduction  endosome membrane  postsynaptic density  actin cytoskeleton  dendritic spine  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  phosphatidylinositol phosphate binding  
NDEx NetworkARHGAP32
Atlas of Cancer Signalling NetworkARHGAP32
Wikipedia pathwaysARHGAP32
Orthology - Evolution
OrthoDB9743
GeneTree (enSembl)ENSG00000134909
Phylogenetic Trees/Animal Genes : TreeFamARHGAP32
Homologs : HomoloGeneARHGAP32
Homology/Alignments : Family Browser (UCSC)ARHGAP32
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP32/AHNAK [11q24.3/11q12.3]  
Fusion : MitelmanARHGAP32/C20orf24 [11q24.3/20q11.23]  
Fusion : MitelmanARHGAP32/CWF19L2 [11q24.3/11q22.3]  
Fusion : MitelmanARHGAP32/FCHSD2 [11q24.3/11q13.4]  
Fusion : MitelmanYWHAB/ARHGAP32 [20q13.12/11q24.3]  
Fusion : QuiverARHGAP32
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP32 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP32
dbVarARHGAP32
ClinVarARHGAP32
MonarchARHGAP32
1000_GenomesARHGAP32 
Exome Variant ServerARHGAP32
GNOMAD BrowserENSG00000134909
Varsome BrowserARHGAP32
ACMGARHGAP32 variants
VarityA7KAX9
Genomic Variants (DGV)ARHGAP32 [DGVbeta]
DECIPHERARHGAP32 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP32 
Mutations
ICGC Data PortalARHGAP32 
TCGA Data PortalARHGAP32 
Broad Tumor PortalARHGAP32
OASIS PortalARHGAP32 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP32  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARHGAP32
Mutations and Diseases : HGMDARHGAP32
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARHGAP32
DgiDB (Drug Gene Interaction Database)ARHGAP32
DoCM (Curated mutations)ARHGAP32
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP32
Cancer3DARHGAP32
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608541   
Orphanet
DisGeNETARHGAP32
MedgenARHGAP32
Genetic Testing Registry ARHGAP32
NextProtA7KAX9 [Medical]
GENETestsARHGAP32
Target ValidationARHGAP32
Huge Navigator ARHGAP32 [HugePedia]
ClinGenARHGAP32
Clinical trials, drugs, therapy
MyCancerGenomeARHGAP32
Protein Interactions : CTDARHGAP32
Pharm GKB GenePA165543138
PharosA7KAX9
Clinical trialARHGAP32
Miscellaneous
canSAR (ICR)ARHGAP32
HarmonizomeARHGAP32
DataMed IndexARHGAP32
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARHGAP32
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 14:59:58 CEST 2021

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