| Nomenclature |
|---|
| HGNC (Hugo) | ARHGAP35 4591 |
| Cards |
|---|
| Entrez_Gene (NCBI) | ARHGAP35 2909 Rho GTPase activating protein 35 |
| Aliases | GRF-1; GRLF1; P190-A; P190A; |
| p190ARhoGAP; p190RhoGAP |
| GeneCards (Weizmann) | ARHGAP35 |
| Ensembl hg19 (Hinxton) | ENSG00000160007 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000160007 [Gene_View] ENSG00000160007 [Sequence] chr19:46918676-47005076 [Contig_View] ARHGAP35 [Vega] |
| ICGC DataPortal | ENSG00000160007 |
| TCGA cBioPortal | ARHGAP35 |
| AceView (NCBI) | ARHGAP35 |
| Genatlas (Paris) | ARHGAP35 |
| WikiGenes | 2909 |
| SOURCE (Princeton) | ARHGAP35 |
| Genetics Home Reference (NIH) | ARHGAP35 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | ARHGAP35 - chr19:46918676-47005076 + 19q13.32 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | ARHGAP35 - 19q13.32 [Description] (hg19-Feb_2009) |
| GoldenPath | ARHGAP35 - 19q13.32 [CytoView hg19] ARHGAP35 - 19q13.32 [CytoView hg38] |
| ImmunoBase | ENSG00000160007 |
| Mapping of homologs : NCBI | ARHGAP35 [Mapview hg19] ARHGAP35 [Mapview hg38] |
| OMIM | 605277 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB051509 AF159851 AK096123 AK097314 AK298356 |
| RefSeq transcript (Entrez) | NM_004491 NM_024342 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | ARHGAP35 |
| Alternative Splicing Gallery | ENSG00000160007 |
| Gene Expression | ARHGAP35 [ NCBI-GEO ] ARHGAP35 [ EBI - ARRAY_EXPRESS ]
ARHGAP35 [ SEEK ] ARHGAP35 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | ARHGAP35 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2909 |
| GTEX Portal (Tissue expression) | ARHGAP35 |
| Human Protein Atlas | ENSG00000160007-ARHGAP35 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q9NRY4 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q9NRY4 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q9NRY4 |
| Splice isoforms : SwissVar | Q9NRY4 |
| PhosPhoSitePlus | Q9NRY4 |
| Domaine pattern : Prosite (Expaxy) | FF (PS51676) PG1 (PS51852) PG2 (PS51853) RHOGAP (PS50238) |
| Domains : Interpro (EBI) | FF_domain FF_domain_sf P-loop_NTPase pG1 Rho_GTPase_activation_prot RhoGAP-FF1 RhoGAP_dom RhoGAP_pG2 Small_GTPase |
| Domain families : Pfam (Sanger) | FF (PF01846) Ras (PF00071) RhoGAP (PF00620) RhoGAP-FF1 (PF16512) |
| Domain families : Pfam (NCBI) | pfam01846 pfam00071 pfam00620 pfam16512 |
| Domain families : Smart (EMBL) | FF (SM00441) RhoGAP (SM00324) |
| Conserved Domain (NCBI) | ARHGAP35 |
| DMDM Disease mutations | 2909 |
| Blocks (Seattle) | ARHGAP35 |
| PDB (RSDB) | 2K85 3C5H 3FK2 |
| PDB Europe | 2K85 3C5H 3FK2 |
| PDB (PDBSum) | 2K85 3C5H 3FK2 |
| PDB (IMB) | 2K85 3C5H 3FK2 |
| Structural Biology KnowledgeBase | 2K85 3C5H 3FK2 |
| SCOP (Structural Classification of Proteins) | 2K85 3C5H 3FK2 |
| CATH (Classification of proteins structures) | 2K85 3C5H 3FK2 |
| Superfamily | Q9NRY4 |
| Human Protein Atlas [tissue] | ENSG00000160007-ARHGAP35 [tissue] |
| Peptide Atlas | Q9NRY4 |
| HPRD | 05592 |
| IPI | IPI00334715 IPI00718985 IPI01015086 IPI00976800 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q9NRY4 |
| IntAct (EBI) | Q9NRY4 |
| FunCoup | ENSG00000160007 |
| BioGRID | ARHGAP35 |
| STRING (EMBL) | ARHGAP35 |
| ZODIAC | ARHGAP35 |
| Ontologies - Pathways |
|---|
| QuickGO | Q9NRY4 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific neural tube closure DNA binding transcription corepressor activity GTPase activity GTPase activator activity GTPase activator activity GTP binding phospholipid binding nucleus cytosol plasma membrane transcription, DNA-templated signal transduction axon guidance axonal fasciculation regulation of actin polymerization or depolymerization regulation of cell shape positive regulation of neuron projection development actin cytoskeleton cell migration central nervous system neuron axonogenesis mammary gland development forebrain development establishment or maintenance of actin cytoskeleton polarity cellular response to extracellular stimulus regulation of actin cytoskeleton organization negative regulation of Rho protein signal transduction ciliary basal body camera-type eye development negative regulation of vascular permeability positive regulation of GTPase activity wound healing, spreading of cells positive regulation of cilium assembly negative regulation of transcription, DNA-templated regulation of axonogenesis regulation of small GTPase mediated signal transduction neuron projection guidance |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II RNA polymerase II regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific neural tube closure DNA binding transcription corepressor activity GTPase activity GTPase activator activity GTPase activator activity GTP binding phospholipid binding nucleus cytosol plasma membrane transcription, DNA-templated signal transduction axon guidance axonal fasciculation regulation of actin polymerization or depolymerization regulation of cell shape positive regulation of neuron projection development actin cytoskeleton cell migration central nervous system neuron axonogenesis mammary gland development forebrain development establishment or maintenance of actin cytoskeleton polarity cellular response to extracellular stimulus regulation of actin cytoskeleton organization negative regulation of Rho protein signal transduction ciliary basal body camera-type eye development negative regulation of vascular permeability positive regulation of GTPase activity wound healing, spreading of cells positive regulation of cilium assembly negative regulation of transcription, DNA-templated regulation of axonogenesis regulation of small GTPase mediated signal transduction neuron projection guidance |
| Pathways : KEGG | Focal adhesion Leukocyte transendothelial migration Regulation of actin cytoskeleton |
| NDEx Network | ARHGAP35 |
| Atlas of Cancer Signalling Network | ARHGAP35 |
| Wikipedia pathways | ARHGAP35 |
| Orthology - Evolution |
|---|
| OrthoDB | 2909 |
| GeneTree (enSembl) | ENSG00000160007 |
| Phylogenetic Trees/Animal Genes : TreeFam | ARHGAP35 |
| HOGENOM | Q9NRY4 |
| Homologs : HomoloGene | ARHGAP35 |
| Homology/Alignments : Family Browser (UCSC) | ARHGAP35 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | ARHGAP35/COL22A1 [19q13.32/8q24.23] |
| Fusion Portal | ARHGAP35 19q13.32 COL22A1 8q24.23 BRCA |
| Fusion : Quiver | ARHGAP35 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | ARHGAP35 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | ARHGAP35 |
| dbVar | ARHGAP35 |
| ClinVar | ARHGAP35 |
| 1000_Genomes | ARHGAP35 |
| Exome Variant Server | ARHGAP35 |
| ExAC (Exome Aggregation Consortium) | ENSG00000160007 |
| GNOMAD Browser | ENSG00000160007 |
| Varsome Browser | ARHGAP35 |
| Genetic variants : HAPMAP | 2909 |
| Genomic Variants (DGV) | ARHGAP35 [DGVbeta] |
| DECIPHER | ARHGAP35 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | ARHGAP35 |
| Mutations |
|---|
| ICGC Data Portal | ARHGAP35 |
| TCGA Data Portal | ARHGAP35 |
| Broad Tumor Portal | ARHGAP35 |
| OASIS Portal | ARHGAP35 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | ARHGAP35 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | ARHGAP35 |
| Mutations and Diseases : HGMD | ARHGAP35 |
| intOGen Portal | ARHGAP35 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search ARHGAP35 |
| DgiDB (Drug Gene Interaction Database) | ARHGAP35 |
| DoCM (Curated mutations) | ARHGAP35 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | ARHGAP35 (select a term) |
| intoGen | ARHGAP35 |
| Cancer3D | ARHGAP35(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 605277 |
| Orphanet | |
| DisGeNET | ARHGAP35 |
| Medgen | ARHGAP35 |
| Genetic Testing Registry | ARHGAP35
|
| NextProt | Q9NRY4 [Medical] |
| TSGene | 2909 |
| GENETests | ARHGAP35 |
| Target Validation | ARHGAP35 |
| Huge Navigator |
ARHGAP35 [HugePedia] |
| snp3D : Map Gene to Disease | 2909 |
| BioCentury BCIQ | ARHGAP35 |
| ClinGen | ARHGAP35 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 2909 |
| Chemical/Pharm GKB Gene | PA28988 |
| Clinical trial | ARHGAP35 |
| Miscellaneous |
|---|
| canSAR (ICR) | ARHGAP35 (select the gene name) |
| DataMed Index | ARHGAP35 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 74 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | ARHGAP35 |
| EVEX | ARHGAP35 |
| GoPubMed | ARHGAP35 |
| iHOP | ARHGAP35 |
