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ARHGAP35 (Rho GTPase activating protein 35)

Identity

Alias (NCBI)GRF-1
GRLF1
P190-A
P190A
p190ARhoGAP
p190RhoGAP
HGNC (Hugo) ARHGAP35
HGNC Alias symbGRF-1
p190ARhoGAP
P190A
KIAA1722
p190RhoGAP
HGNC Previous nameGRLF1
HGNC Previous nameglucocorticoid receptor DNA binding factor 1
LocusID (NCBI) 2909
Atlas_Id 52237
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 46860997 and ends at 47005076 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP35 (19q13.32) / ARHGAP35 (19q13.32)ARHGAP35 (19q13.32) / COL22A1 (8q24.23)ARHGAP35 (19q13.32) / RERE (1p36.23)
ARHGAP35 (19q13.32) / VRK3 (19q13.33)HCFC1 (Xq28) / ARHGAP35 (19q13.32)P4HTM (3p21.31) / ARHGAP35 (19q13.32)
SLC6A1 (3p25.3) / ARHGAP35 (19q13.32)ARHGAP35 19q13.32 / COL22A1 8q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(8;19)(q24;q13) ARHGAP35/COL22A1

External links

Nomenclature
HGNC (Hugo)ARHGAP35   4591
Cards
Entrez_Gene (NCBI)ARHGAP35    Rho GTPase activating protein 35
AliasesGRF-1; GRLF1; P190-A; P190A; 
p190ARhoGAP; p190RhoGAP
GeneCards (Weizmann)ARHGAP35
Ensembl hg19 (Hinxton)ENSG00000160007 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160007 [Gene_View]  ENSG00000160007 [Sequence]  chr19:46860997-47005076 [Contig_View]  ARHGAP35 [Vega]
ICGC DataPortalENSG00000160007
TCGA cBioPortalARHGAP35
AceView (NCBI)ARHGAP35
Genatlas (Paris)ARHGAP35
SOURCE (Princeton)ARHGAP35
Genetics Home Reference (NIH)ARHGAP35
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP35  -     chr19:46860997-47005076 +  19q13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP35  -     19q13.32   [Description]    (hg19-Feb_2009)
GoldenPathARHGAP35 - 19q13.32 [CytoView hg19]  ARHGAP35 - 19q13.32 [CytoView hg38]
ImmunoBaseENSG00000160007
genome Data Viewer NCBIARHGAP35 [Mapview hg19]  
OMIM605277   
Gene and transcription
Genbank (Entrez)AB051509 AF159851 AK096123 AK097314 AK298356
RefSeq transcript (Entrez)NM_004491 NM_024342
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP35
Alternative Splicing GalleryENSG00000160007
Gene ExpressionARHGAP35 [ NCBI-GEO ]   ARHGAP35 [ EBI - ARRAY_EXPRESS ]   ARHGAP35 [ SEEK ]   ARHGAP35 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP35 [ Firebrowse - Broad ]
GenevisibleExpression of ARHGAP35 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2909
GTEX Portal (Tissue expression)ARHGAP35
Human Protein AtlasENSG00000160007-ARHGAP35 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRY4
Splice isoforms : SwissVarQ9NRY4
PhosPhoSitePlusQ9NRY4
Domaine pattern : Prosite (Expaxy)FF (PS51676)    PG1 (PS51852)    PG2 (PS51853)    RHOGAP (PS50238)   
Domains : Interpro (EBI)FF_domain    FF_domain_sf    P-loop_NTPase    pG1    Rho_GTPase_activation_prot    RhoGAP-FF1    RhoGAP_dom    RhoGAP_pG2    Small_GTPase   
Domain families : Pfam (Sanger)FF (PF01846)    Ras (PF00071)    RhoGAP (PF00620)    RhoGAP-FF1 (PF16512)   
Domain families : Pfam (NCBI)pfam01846    pfam00071    pfam00620    pfam16512   
Domain families : Smart (EMBL)FF (SM00441)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP35
Blocks (Seattle)ARHGAP35
PDB (RSDB)2K85    3C5H    3FK2   
PDB Europe2K85    3C5H    3FK2   
PDB (PDBSum)2K85    3C5H    3FK2   
PDB (IMB)2K85    3C5H    3FK2   
Structural Biology KnowledgeBase2K85    3C5H    3FK2   
SCOP (Structural Classification of Proteins)2K85    3C5H    3FK2   
CATH (Classification of proteins structures)2K85    3C5H    3FK2   
SuperfamilyQ9NRY4
Human Protein Atlas [tissue]ENSG00000160007-ARHGAP35 [tissue]
Peptide AtlasQ9NRY4
HPRD05592
IPIIPI00334715   IPI00718985   IPI01015086   IPI00976800   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRY4
IntAct (EBI)Q9NRY4
BioGRIDARHGAP35
STRING (EMBL)ARHGAP35
ZODIACARHGAP35
Ontologies - Pathways
QuickGOQ9NRY4
Ontology : AmiGOneural tube closure  DNA binding  GTPase activity  GTPase activator activity  GTPase activator activity  GTP binding  phospholipid binding  nucleus  cytosol  plasma membrane  signal transduction  axon guidance  axonal fasciculation  regulation of actin polymerization or depolymerization  regulation of cell shape  positive regulation of neuron projection development  actin cytoskeleton  cell migration  central nervous system neuron axonogenesis  mammary gland development  forebrain development  establishment or maintenance of actin cytoskeleton polarity  cellular response to extracellular stimulus  regulation of actin cytoskeleton organization  negative regulation of Rho protein signal transduction  ciliary basal body  camera-type eye development  negative regulation of vascular permeability  positive regulation of GTPase activity  wound healing, spreading of cells  positive regulation of cilium assembly  regulation of axonogenesis  regulation of small GTPase mediated signal transduction  neuron projection guidance  
Ontology : EGO-EBIneural tube closure  DNA binding  GTPase activity  GTPase activator activity  GTPase activator activity  GTP binding  phospholipid binding  nucleus  cytosol  plasma membrane  signal transduction  axon guidance  axonal fasciculation  regulation of actin polymerization or depolymerization  regulation of cell shape  positive regulation of neuron projection development  actin cytoskeleton  cell migration  central nervous system neuron axonogenesis  mammary gland development  forebrain development  establishment or maintenance of actin cytoskeleton polarity  cellular response to extracellular stimulus  regulation of actin cytoskeleton organization  negative regulation of Rho protein signal transduction  ciliary basal body  camera-type eye development  negative regulation of vascular permeability  positive regulation of GTPase activity  wound healing, spreading of cells  positive regulation of cilium assembly  regulation of axonogenesis  regulation of small GTPase mediated signal transduction  neuron projection guidance  
Pathways : KEGGFocal adhesion    Leukocyte transendothelial migration    Regulation of actin cytoskeleton   
NDEx NetworkARHGAP35
Atlas of Cancer Signalling NetworkARHGAP35
Wikipedia pathwaysARHGAP35
Orthology - Evolution
OrthoDB2909
GeneTree (enSembl)ENSG00000160007
Phylogenetic Trees/Animal Genes : TreeFamARHGAP35
HOGENOMQ9NRY4
Homologs : HomoloGeneARHGAP35
Homology/Alignments : Family Browser (UCSC)ARHGAP35
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP35/COL22A1 [19q13.32/8q24.23]  
Fusion PortalARHGAP35 19q13.32 COL22A1 8q24.23 BRCA
Fusion : QuiverARHGAP35
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP35 [hg38]
dbVarARHGAP35
ClinVarARHGAP35
MonarchARHGAP35
1000_GenomesARHGAP35 
Exome Variant ServerARHGAP35
GNOMAD BrowserENSG00000160007
Varsome BrowserARHGAP35
Genomic Variants (DGV)ARHGAP35 [DGVbeta]
DECIPHERARHGAP35 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP35 
Mutations
ICGC Data PortalARHGAP35 
TCGA Data PortalARHGAP35 
Broad Tumor PortalARHGAP35
OASIS PortalARHGAP35 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP35  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARHGAP35
Mutations and Diseases : HGMDARHGAP35
intOGen PortalARHGAP35
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP35
DgiDB (Drug Gene Interaction Database)ARHGAP35
DoCM (Curated mutations)ARHGAP35 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP35 (select a term)
intoGenARHGAP35
Cancer3DARHGAP35(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605277   
Orphanet
DisGeNETARHGAP35
MedgenARHGAP35
Genetic Testing Registry ARHGAP35
NextProtQ9NRY4 [Medical]
GENETestsARHGAP35
Target ValidationARHGAP35
Huge Navigator ARHGAP35 [HugePedia]
ClinGenARHGAP35
Clinical trials, drugs, therapy
MyCancerGenomeARHGAP35
Protein Interactions : CTD
Pharm GKB GenePA28988
PharosQ9NRY4
Clinical trialARHGAP35
Miscellaneous
canSAR (ICR)ARHGAP35 (select the gene name)
HarmonizomeARHGAP35
DataMed IndexARHGAP35
Probes
Litterature
PubMed76 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARHGAP35
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:05:59 CET 2021
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