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ARHGAP35 (Rho GTPase activating protein 35)

Identity

Alias_namesGRLF1
glucocorticoid receptor DNA binding factor 1
Alias_symbol (synonym)GRF-1
p190ARhoGAP
P190A
KIAA1722
p190RhoGAP
Other aliasP190-A
HGNC (Hugo) ARHGAP35
LocusID (NCBI) 2909
Atlas_Id 52237
Location 19q13.32  [Link to chromosome band 19q13]
Location_base_pair Starts at 47421933 and ends at 47508333 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGAP35 (19q13.32) / ARHGAP35 (19q13.32)ARHGAP35 (19q13.32) / COL22A1 (8q24.23)ARHGAP35 (19q13.32) / RERE (1p36.23)
ARHGAP35 (19q13.32) / VRK3 (19q13.33)HCFC1 (Xq28) / ARHGAP35 (19q13.32)P4HTM (3p21.31) / ARHGAP35 (19q13.32)
SLC6A1 (3p25.3) / ARHGAP35 (19q13.32)ARHGAP35 19q13.32 / COL22A1 8q24.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP35   4591
Cards
Entrez_Gene (NCBI)ARHGAP35  2909  Rho GTPase activating protein 35
AliasesGRF-1; GRLF1; P190-A; P190A; 
p190ARhoGAP; p190RhoGAP
GeneCards (Weizmann)ARHGAP35
Ensembl hg19 (Hinxton)ENSG00000160007 [Gene_View]  chr19:47421933-47508333 [Contig_View]  ARHGAP35 [Vega]
Ensembl hg38 (Hinxton)ENSG00000160007 [Gene_View]  chr19:47421933-47508333 [Contig_View]  ARHGAP35 [Vega]
ICGC DataPortalENSG00000160007
TCGA cBioPortalARHGAP35
AceView (NCBI)ARHGAP35
Genatlas (Paris)ARHGAP35
WikiGenes2909
SOURCE (Princeton)ARHGAP35
Genetics Home Reference (NIH)ARHGAP35
Genomic and cartography
GoldenPath hg19 (UCSC)ARHGAP35  -     chr19:47421933-47508333 +  19q13.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARHGAP35  -     19q13.32   [Description]    (hg38-Dec_2013)
EnsemblARHGAP35 - 19q13.32 [CytoView hg19]  ARHGAP35 - 19q13.32 [CytoView hg38]
Mapping of homologs : NCBIARHGAP35 [Mapview hg19]  ARHGAP35 [Mapview hg38]
OMIM605277   
Gene and transcription
Genbank (Entrez)AB051509 AF159851 AK096123 AK097314 AK298356
RefSeq transcript (Entrez)NM_004491 NM_024342
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)ARHGAP35
Cluster EST : UnigeneHs.509447 [ NCBI ]
CGAP (NCI)Hs.509447
Alternative Splicing GalleryENSG00000160007
Gene ExpressionARHGAP35 [ NCBI-GEO ]   ARHGAP35 [ EBI - ARRAY_EXPRESS ]   ARHGAP35 [ SEEK ]   ARHGAP35 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP35 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2909
GTEX Portal (Tissue expression)ARHGAP35
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRY4
Splice isoforms : SwissVarQ9NRY4
PhosPhoSitePlusQ9NRY4
Domaine pattern : Prosite (Expaxy)FF (PS51676)    RHOGAP (PS50238)   
Domains : Interpro (EBI)FF_domain    P-loop_NTPase    Rho_GTPase_activation_prot    RhoGAP-FF1    RhoGAP_dom    Small_GTPase   
Domain families : Pfam (Sanger)FF (PF01846)    Ras (PF00071)    RhoGAP (PF00620)    RhoGAP-FF1 (PF16512)   
Domain families : Pfam (NCBI)pfam01846    pfam00071    pfam00620    pfam16512   
Domain families : Smart (EMBL)FF (SM00441)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP35
DMDM Disease mutations2909
Blocks (Seattle)ARHGAP35
PDB (SRS)2K85    3C5H    3FK2   
PDB (PDBSum)2K85    3C5H    3FK2   
PDB (IMB)2K85    3C5H    3FK2   
PDB (RSDB)2K85    3C5H    3FK2   
Structural Biology KnowledgeBase2K85    3C5H    3FK2   
SCOP (Structural Classification of Proteins)2K85    3C5H    3FK2   
CATH (Classification of proteins structures)2K85    3C5H    3FK2   
SuperfamilyQ9NRY4
Human Protein AtlasENSG00000160007
Peptide AtlasQ9NRY4
HPRD05592
IPIIPI00334715   IPI00718985   IPI01015086   IPI00976800   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRY4
IntAct (EBI)Q9NRY4
FunCoupENSG00000160007
BioGRIDARHGAP35
STRING (EMBL)ARHGAP35
ZODIACARHGAP35
Ontologies - Pathways
QuickGOQ9NRY4
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  neural tube closure  DNA binding  transcription corepressor activity  GTPase activator activity  GTP binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  small GTPase mediated signal transduction  regulation of cell shape  positive regulation of neuron projection development  actin cytoskeleton  forebrain development  negative regulation of Rho protein signal transduction  camera-type eye development  negative regulation of vascular permeability  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of transcription, DNA-templated  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II regulatory region sequence-specific DNA binding  transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding  neural tube closure  DNA binding  transcription corepressor activity  GTPase activator activity  GTP binding  nucleus  cytoplasm  cytosol  transcription, DNA-templated  small GTPase mediated signal transduction  regulation of cell shape  positive regulation of neuron projection development  actin cytoskeleton  forebrain development  negative regulation of Rho protein signal transduction  camera-type eye development  negative regulation of vascular permeability  positive regulation of GTPase activity  positive regulation of GTPase activity  negative regulation of transcription, DNA-templated  regulation of small GTPase mediated signal transduction  
Pathways : KEGGFocal adhesion    Leukocyte transendothelial migration    Regulation of actin cytoskeleton   
NDEx NetworkARHGAP35
Atlas of Cancer Signalling NetworkARHGAP35
Wikipedia pathwaysARHGAP35
Orthology - Evolution
OrthoDB2909
GeneTree (enSembl)ENSG00000160007
Phylogenetic Trees/Animal Genes : TreeFamARHGAP35
HOVERGENQ9NRY4
HOGENOMQ9NRY4
Homologs : HomoloGeneARHGAP35
Homology/Alignments : Family Browser (UCSC)ARHGAP35
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP35/COL22A1 [19q13.32/8q24.23]  
Fusion: TCGAARHGAP35 19q13.32 COL22A1 8q24.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP35 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP35
dbVarARHGAP35
ClinVarARHGAP35
1000_GenomesARHGAP35 
Exome Variant ServerARHGAP35
ExAC (Exome Aggregation Consortium)ARHGAP35 (select the gene name)
Genetic variants : HAPMAP2909
Genomic Variants (DGV)ARHGAP35 [DGVbeta]
DECIPHER (Syndromes)19:47421933-47508333  ENSG00000160007
CONAN: Copy Number AnalysisARHGAP35 
Mutations
ICGC Data PortalARHGAP35 
TCGA Data PortalARHGAP35 
Broad Tumor PortalARHGAP35
OASIS PortalARHGAP35 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP35  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP35
intOGen PortalARHGAP35
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP35
DgiDB (Drug Gene Interaction Database)ARHGAP35
DoCM (Curated mutations)ARHGAP35 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP35 (select a term)
intoGenARHGAP35
Cancer3DARHGAP35(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605277   
Orphanet
MedgenARHGAP35
Genetic Testing Registry ARHGAP35
NextProtQ9NRY4 [Medical]
TSGene2909
GENETestsARHGAP35
Huge Navigator ARHGAP35 [HugePedia]
snp3D : Map Gene to Disease2909
BioCentury BCIQARHGAP35
ClinGenARHGAP35
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2909
Chemical/Pharm GKB GenePA28988
Clinical trialARHGAP35
Miscellaneous
canSAR (ICR)ARHGAP35 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP35
EVEXARHGAP35
GoPubMedARHGAP35
iHOPARHGAP35
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:56:22 CET 2017

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