Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ARHGAP42 (Rho GTPase activating protein 42)

Identity

Alias_symbol (synonym)FLJ32810
GRAF3
Other aliasAD031
TMEM133
HGNC (Hugo) ARHGAP42
LocusID (NCBI) 143872
Atlas_Id 60472
Location 11q22.1  [Link to chromosome band 11q22]
Location_base_pair Starts at 100687240 and ends at 100993945 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP42 (11q22.1) / ARHGAP42 (11q22.1)ARHGAP42 (11q22.1) / PGR (11q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  ARHGAP42/PGR (11q22)
ARHGAP42/TMEM123 (11q22)

External links

Nomenclature
HGNC (Hugo)ARHGAP42   26545
Cards
Entrez_Gene (NCBI)ARHGAP42  143872  Rho GTPase activating protein 42
AliasesAD031; GRAF3; TMEM133
GeneCards (Weizmann)ARHGAP42
Ensembl hg19 (Hinxton)ENSG00000165895 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165895 [Gene_View]  ENSG00000165895 [Sequence]  chr11:100687240-100993945 [Contig_View]  ARHGAP42 [Vega]
ICGC DataPortalENSG00000165895
TCGA cBioPortalARHGAP42
AceView (NCBI)ARHGAP42
Genatlas (Paris)ARHGAP42
WikiGenes143872
SOURCE (Princeton)ARHGAP42
Genetics Home Reference (NIH)ARHGAP42
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP42  -     chr11:100687240-100993945 +  11q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP42  -     11q22.1   [Description]    (hg19-Feb_2009)
GoldenPathARHGAP42 - 11q22.1 [CytoView hg19]  ARHGAP42 - 11q22.1 [CytoView hg38]
ImmunoBaseENSG00000165895
Mapping of homologs : NCBIARHGAP42 [Mapview hg19]  ARHGAP42 [Mapview hg38]
OMIM615936   
Gene and transcription
Genbank (Entrez)AF247167 AI672473 AI677857 AK023666 AK057372
RefSeq transcript (Entrez)NM_001367945 NM_032021 NM_152432
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP42
Alternative Splicing GalleryENSG00000165895
Gene ExpressionARHGAP42 [ NCBI-GEO ]   ARHGAP42 [ EBI - ARRAY_EXPRESS ]   ARHGAP42 [ SEEK ]   ARHGAP42 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP42 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143872
GTEX Portal (Tissue expression)ARHGAP42
Human Protein AtlasENSG00000165895-ARHGAP42 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6NI28   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6NI28  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6NI28
Splice isoforms : SwissVarA6NI28
PhosPhoSitePlusA6NI28
Domaine pattern : Prosite (Expaxy)PH_DOMAIN (PS50003)    RHOGAP (PS50238)    SH3 (PS50002)   
Domains : Interpro (EBI)AH/BAR_dom_sf    PH-like_dom_sf    PH_domain    Rho_GTPase_activation_prot    RhoGAP_dom    SH3-like_dom_sf    SH3_domain   
Domain families : Pfam (Sanger)PH (PF00169)    RhoGAP (PF00620)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00169    pfam00620    pfam14604   
Domain families : Smart (EMBL)PH (SM00233)  RhoGAP (SM00324)  SH3 (SM00326)  
Conserved Domain (NCBI)ARHGAP42
DMDM Disease mutations143872
Blocks (Seattle)ARHGAP42
SuperfamilyA6NI28
Human Protein Atlas [tissue]ENSG00000165895-ARHGAP42 [tissue]
Peptide AtlasA6NI28
IPIIPI00902744   IPI00939716   IPI00981572   
Protein Interaction databases
DIP (DOE-UCLA)A6NI28
IntAct (EBI)A6NI28
FunCoupENSG00000165895
BioGRIDARHGAP42
STRING (EMBL)ARHGAP42
ZODIACARHGAP42
Ontologies - Pathways
QuickGOA6NI28
Ontology : AmiGOnegative regulation of systemic arterial blood pressure  GTPase activator activity  GTPase activator activity  cellular_component  signal transduction  negative regulation of Rho protein signal transduction  activation of GTPase activity  negative regulation of vascular smooth muscle contraction  
Ontology : EGO-EBInegative regulation of systemic arterial blood pressure  GTPase activator activity  GTPase activator activity  cellular_component  signal transduction  negative regulation of Rho protein signal transduction  activation of GTPase activity  negative regulation of vascular smooth muscle contraction  
NDEx NetworkARHGAP42
Atlas of Cancer Signalling NetworkARHGAP42
Wikipedia pathwaysARHGAP42
Orthology - Evolution
OrthoDB143872
GeneTree (enSembl)ENSG00000165895
Phylogenetic Trees/Animal Genes : TreeFamARHGAP42
HOGENOMA6NI28
Homologs : HomoloGeneARHGAP42
Homology/Alignments : Family Browser (UCSC)ARHGAP42
Gene fusions - Rearrangements
Fusion : QuiverARHGAP42
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP42 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP42
dbVarARHGAP42
ClinVarARHGAP42
1000_GenomesARHGAP42 
Exome Variant ServerARHGAP42
ExAC (Exome Aggregation Consortium)ENSG00000165895
GNOMAD BrowserENSG00000165895
Varsome BrowserARHGAP42
Genetic variants : HAPMAP143872
Genomic Variants (DGV)ARHGAP42 [DGVbeta]
DECIPHERARHGAP42 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP42 
Mutations
ICGC Data PortalARHGAP42 
TCGA Data PortalARHGAP42 
Broad Tumor PortalARHGAP42
OASIS PortalARHGAP42 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP42  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARHGAP42
Mutations and Diseases : HGMDARHGAP42
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP42
DgiDB (Drug Gene Interaction Database)ARHGAP42
DoCM (Curated mutations)ARHGAP42 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP42 (select a term)
intoGenARHGAP42
Cancer3DARHGAP42(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615936   
Orphanet
DisGeNETARHGAP42
MedgenARHGAP42
Genetic Testing Registry ARHGAP42
NextProtA6NI28 [Medical]
TSGene143872
GENETestsARHGAP42
Target ValidationARHGAP42
Huge Navigator ARHGAP42 [HugePedia]
snp3D : Map Gene to Disease143872
BioCentury BCIQARHGAP42
ClinGenARHGAP42
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD143872
Chemical/Pharm GKB GenePA165543186
Clinical trialARHGAP42
Miscellaneous
canSAR (ICR)ARHGAP42 (select the gene name)
HarmonizomeARHGAP42
DataMed IndexARHGAP42
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP42
EVEXARHGAP42
GoPubMedARHGAP42
iHOPARHGAP42
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 10 11:25:07 CEST 2020
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