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ARHGAP45 (Rho GTPase activating protein 45)

Identity

Alias_namesHMHA1
histocompatibility (minor) HA-1
Alias_symbol (synonym)KIAA0223
HA-1
Other aliasHLA-HA1
HGNC (Hugo) ARHGAP45
LocusID (NCBI) 23526
Atlas_Id 55800
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1065923 and ends at 1087831 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP45   17102
Cards
Entrez_Gene (NCBI)ARHGAP45  23526  Rho GTPase activating protein 45
AliasesHA-1; HLA-HA1; HMHA1
GeneCards (Weizmann)ARHGAP45
Ensembl hg19 (Hinxton)ENSG00000180448 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180448 [Gene_View]  chr19:1065923-1087831 [Contig_View]  ARHGAP45 [Vega]
ICGC DataPortalENSG00000180448
TCGA cBioPortalARHGAP45
AceView (NCBI)ARHGAP45
Genatlas (Paris)ARHGAP45
WikiGenes23526
SOURCE (Princeton)ARHGAP45
Genetics Home Reference (NIH)ARHGAP45
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP45  -     chr19:1065923-1087831 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP45  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblARHGAP45 - 19p13.3 [CytoView hg19]  ARHGAP45 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIARHGAP45 [Mapview hg19]  ARHGAP45 [Mapview hg38]
OMIM601155   
Gene and transcription
Genbank (Entrez)AA811117 AK122776 AK128097 AK300341 AK304271
RefSeq transcript (Entrez)NM_001258328 NM_001282334 NM_001282335 NM_001321232 NM_012292
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP45
Cluster EST : UnigeneHs.710732 [ NCBI ]
CGAP (NCI)Hs.710732
Alternative Splicing GalleryENSG00000180448
Gene ExpressionARHGAP45 [ NCBI-GEO ]   ARHGAP45 [ EBI - ARRAY_EXPRESS ]   ARHGAP45 [ SEEK ]   ARHGAP45 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP45 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23526
GTEX Portal (Tissue expression)ARHGAP45
Human Protein AtlasENSG00000180448-ARHGAP45 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92619   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92619  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92619
Splice isoforms : SwissVarQ92619
PhosPhoSitePlusQ92619
Domaine pattern : Prosite (Expaxy)F_BAR (PS51741)    RHOGAP (PS50238)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)F_BAR    FCH_dom    PE/DAG-bd    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00620   
Domain families : Smart (EMBL)C1 (SM00109)  FCH (SM00055)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP45
DMDM Disease mutations23526
Blocks (Seattle)ARHGAP45
PDB (SRS)3D25    3FT3   
PDB (PDBSum)3D25    3FT3   
PDB (IMB)3D25    3FT3   
PDB (RSDB)3D25    3FT3   
Structural Biology KnowledgeBase3D25    3FT3   
SCOP (Structural Classification of Proteins)3D25    3FT3   
CATH (Classification of proteins structures)3D25    3FT3   
SuperfamilyQ92619
Human Protein Atlas [tissue]ENSG00000180448-ARHGAP45 [tissue]
Peptide AtlasQ92619
HPRD03097
IPIIPI00943093   IPI00022471   IPI01011549   IPI00640700   IPI01013340   IPI01015186   
Protein Interaction databases
DIP (DOE-UCLA)Q92619
IntAct (EBI)Q92619
FunCoupENSG00000180448
BioGRIDARHGAP45
STRING (EMBL)ARHGAP45
ZODIACARHGAP45
Ontologies - Pathways
QuickGOQ92619
Ontology : AmiGOGTPase activator activity  protein binding  extracellular region  cytosol  membrane  secretory granule lumen  intracellular signal transduction  azurophil granule lumen  neutrophil degranulation  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activator activity  protein binding  extracellular region  cytosol  membrane  secretory granule lumen  intracellular signal transduction  azurophil granule lumen  neutrophil degranulation  positive regulation of GTPase activity  metal ion binding  regulation of small GTPase mediated signal transduction  
NDEx NetworkARHGAP45
Atlas of Cancer Signalling NetworkARHGAP45
Wikipedia pathwaysARHGAP45
Orthology - Evolution
OrthoDB23526
GeneTree (enSembl)ENSG00000180448
Phylogenetic Trees/Animal Genes : TreeFamARHGAP45
HOVERGENQ92619
HOGENOMQ92619
Homologs : HomoloGeneARHGAP45
Homology/Alignments : Family Browser (UCSC)ARHGAP45
Gene fusions - Rearrangements
Tumor Fusion PortalARHGAP45
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP45 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP45
dbVarARHGAP45
ClinVarARHGAP45
1000_GenomesARHGAP45 
Exome Variant ServerARHGAP45
ExAC (Exome Aggregation Consortium)ENSG00000180448
GNOMAD BrowserENSG00000180448
Genetic variants : HAPMAP23526
Genomic Variants (DGV)ARHGAP45 [DGVbeta]
DECIPHERARHGAP45 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP45 
Mutations
ICGC Data PortalARHGAP45 
TCGA Data PortalARHGAP45 
Broad Tumor PortalARHGAP45
OASIS PortalARHGAP45 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDARHGAP45
BioMutasearch ARHGAP45
DgiDB (Drug Gene Interaction Database)ARHGAP45
DoCM (Curated mutations)ARHGAP45 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP45 (select a term)
intoGenARHGAP45
Cancer3DARHGAP45(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601155   
Orphanet
DisGeNETARHGAP45
MedgenARHGAP45
Genetic Testing Registry ARHGAP45
NextProtQ92619 [Medical]
TSGene23526
GENETestsARHGAP45
Target ValidationARHGAP45
Huge Navigator ARHGAP45 [HugePedia]
snp3D : Map Gene to Disease23526
BioCentury BCIQARHGAP45
ClinGenARHGAP45
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23526
Chemical/Pharm GKB GenePA128394633
Clinical trialARHGAP45
Miscellaneous
canSAR (ICR)ARHGAP45 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP45
EVEXARHGAP45
GoPubMedARHGAP45
iHOPARHGAP45
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:03:36 CET 2017

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