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ARHGAP5 (Rho GTPase activating protein 5)

Identity

Alias_namesGFI2
growth factor independent 2
Alias_symbol (synonym)RhoGAP5
p190-B
p190BRhoGAP
Other alias
HGNC (Hugo) ARHGAP5
LocusID (NCBI) 394
Atlas_Id 50686
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 32077289 and ends at 32159728 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP5 (14q12) / AKAP6 (14q12)ARHGAP5 (14q12) / ARHGAP5 (14q12)ARHGAP5 (14q12) / NUBPL (14q12)
ARHGAP5 (14q12) / TPGS2 (18q12.2)KIAA0391 (14q13.2) / ARHGAP5 (14q12)SMYD3 (1q44) / ARHGAP5 (14q12)
TBK1 (12q14.2) / ARHGAP5 (14q12)ARHGAP5 14q12 C18orf10ARHGAP5 14q12 / NUBPL 14q12
TBK1 12q14.2 / ARHGAP5 14q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP5   675
Cards
Entrez_Gene (NCBI)ARHGAP5  394  Rho GTPase activating protein 5
AliasesGFI2; RhoGAP5; p190-B; p190BRhoGAP
GeneCards (Weizmann)ARHGAP5
Ensembl hg19 (Hinxton)ENSG00000100852 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100852 [Gene_View]  chr14:32077289-32159728 [Contig_View]  ARHGAP5 [Vega]
ICGC DataPortalENSG00000100852
TCGA cBioPortalARHGAP5
AceView (NCBI)ARHGAP5
Genatlas (Paris)ARHGAP5
WikiGenes394
SOURCE (Princeton)ARHGAP5
Genetics Home Reference (NIH)ARHGAP5
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP5  -     chr14:32077289-32159728 +  14q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP5  -     14q12   [Description]    (hg19-Feb_2009)
EnsemblARHGAP5 - 14q12 [CytoView hg19]  ARHGAP5 - 14q12 [CytoView hg38]
Mapping of homologs : NCBIARHGAP5 [Mapview hg19]  ARHGAP5 [Mapview hg38]
OMIM602680   
Gene and transcription
Genbank (Entrez)AB209751 AK023014 AK023468 AK292966 AK307454
RefSeq transcript (Entrez)NM_001030055 NM_001173
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP5
Cluster EST : UnigeneHs.592313 [ NCBI ]
CGAP (NCI)Hs.592313
Alternative Splicing GalleryENSG00000100852
Gene ExpressionARHGAP5 [ NCBI-GEO ]   ARHGAP5 [ EBI - ARRAY_EXPRESS ]   ARHGAP5 [ SEEK ]   ARHGAP5 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)394
GTEX Portal (Tissue expression)ARHGAP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13017   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13017  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13017
Splice isoforms : SwissVarQ13017
PhosPhoSitePlusQ13017
Domaine pattern : Prosite (Expaxy)FF (PS51676)    RHOGAP (PS50238)   
Domains : Interpro (EBI)FF_domain    P-loop_NTPase    Rho_GTPase_activation_prot    RhoGAP-FF1    RhoGAP_dom    Small_GTPase   
Domain families : Pfam (Sanger)FF (PF01846)    Ras (PF00071)    RhoGAP (PF00620)    RhoGAP-FF1 (PF16512)   
Domain families : Pfam (NCBI)pfam01846    pfam00071    pfam00620    pfam16512   
Domain families : Smart (EMBL)FF (SM00441)  RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP5
DMDM Disease mutations394
Blocks (Seattle)ARHGAP5
PDB (SRS)2EE4    2EE5   
PDB (PDBSum)2EE4    2EE5   
PDB (IMB)2EE4    2EE5   
PDB (RSDB)2EE4    2EE5   
Structural Biology KnowledgeBase2EE4    2EE5   
SCOP (Structural Classification of Proteins)2EE4    2EE5   
CATH (Classification of proteins structures)2EE4    2EE5   
SuperfamilyQ13017
Human Protein AtlasENSG00000100852
Peptide AtlasQ13017
HPRD04060
IPIIPI00646885   IPI00013988   IPI00744108   IPI00895772   IPI00654612   IPI01026496   IPI01026143   IPI01025914   IPI01026063   
Protein Interaction databases
DIP (DOE-UCLA)Q13017
IntAct (EBI)Q13017
FunCoupENSG00000100852
BioGRIDARHGAP5
STRING (EMBL)ARHGAP5
ZODIACARHGAP5
Ontologies - Pathways
QuickGOQ13017
Ontology : AmiGOGTPase activity  GTPase activator activity  protein binding  GTP binding  cytoplasm  endoplasmic reticulum  cytosol  cytosol  cell adhesion  Rho protein signal transduction  membrane  mammary gland development  SH2 domain binding  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIGTPase activity  GTPase activator activity  protein binding  GTP binding  cytoplasm  endoplasmic reticulum  cytosol  cytosol  cell adhesion  Rho protein signal transduction  membrane  mammary gland development  SH2 domain binding  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  
Pathways : BIOCARTARho cell motility signaling pathway [Genes]    PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    D4-GDI Signaling Pathway [Genes]   
Pathways : KEGGFocal adhesion    Leukocyte transendothelial migration   
NDEx NetworkARHGAP5
Atlas of Cancer Signalling NetworkARHGAP5
Wikipedia pathwaysARHGAP5
Orthology - Evolution
OrthoDB394
GeneTree (enSembl)ENSG00000100852
Phylogenetic Trees/Animal Genes : TreeFamARHGAP5
HOVERGENQ13017
HOGENOMQ13017
Homologs : HomoloGeneARHGAP5
Homology/Alignments : Family Browser (UCSC)ARHGAP5
Gene fusions - Rearrangements
Fusion : MitelmanARHGAP5/TPGS2 [14q12/18q12.2]  
Fusion : MitelmanTBK1/ARHGAP5 [12q14.2/14q12]  [t(12;14)(q14;q12)]  
Fusion: TCGAARHGAP5 14q12 C18orf10 LUAD
Fusion: TCGAARHGAP5 14q12 NUBPL 14q12 LUSC
Fusion: TCGATBK1 12q14.2 ARHGAP5 14q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP5
dbVarARHGAP5
ClinVarARHGAP5
1000_GenomesARHGAP5 
Exome Variant ServerARHGAP5
ExAC (Exome Aggregation Consortium)ARHGAP5 (select the gene name)
Genetic variants : HAPMAP394
Genomic Variants (DGV)ARHGAP5 [DGVbeta]
DECIPHERARHGAP5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP5 
Mutations
ICGC Data PortalARHGAP5 
TCGA Data PortalARHGAP5 
Broad Tumor PortalARHGAP5
OASIS PortalARHGAP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP5
DgiDB (Drug Gene Interaction Database)ARHGAP5
DoCM (Curated mutations)ARHGAP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP5 (select a term)
intoGenARHGAP5
Cancer3DARHGAP5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602680   
Orphanet
MedgenARHGAP5
Genetic Testing Registry ARHGAP5
NextProtQ13017 [Medical]
TSGene394
GENETestsARHGAP5
Huge Navigator ARHGAP5 [HugePedia]
snp3D : Map Gene to Disease394
BioCentury BCIQARHGAP5
ClinGenARHGAP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD394
Chemical/Pharm GKB GenePA24959
Clinical trialARHGAP5
Miscellaneous
canSAR (ICR)ARHGAP5 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP5
EVEXARHGAP5
GoPubMedARHGAP5
iHOPARHGAP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:06:34 CEST 2017

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