Identity
HGNC
LOCATION
Xp22.2
LOCUSID
ALIAS
RHOGAP6,RHOGAPX-1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 395
MIM: 300118
HGNC: 676
Ensembl: ENSG00000047648
Variants:
dbSNP: 395
ClinVar: 395
TCGA: ENSG00000047648
COSMIC: ARHGAP6
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Rho GTPases | REACTOME | R-HSA-194315 |
| Rho GTPase cycle | REACTOME | R-HSA-194840 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38287795 | 2024 | ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK Signaling. | 0 |
| 38287795 | 2024 | ARHGAP6 Suppresses Breast Cancer Tumor Growth by Promoting Ferroptosis via RhoA-ROCK1-p38 MAPK Signaling. | 0 |
| 36715867 | 2023 | ARHGAP6 inhibits bladder cancer cell viability, migration, and invasion via β-catenin signaling and enhances mitomycin C sensitivity. | 1 |
| 37409526 | 2023 | RhoGAP6 interacts with COPI to regulate protein transport. | 0 |
| 36715867 | 2023 | ARHGAP6 inhibits bladder cancer cell viability, migration, and invasion via β-catenin signaling and enhances mitomycin C sensitivity. | 1 |
| 37409526 | 2023 | RhoGAP6 interacts with COPI to regulate protein transport. | 0 |
| 34338998 | 2021 | MiR-96-5p is an oncogene in lung adenocarcinoma and facilitates tumor progression through ARHGAP6 downregulation. | 8 |
| 34338998 | 2021 | MiR-96-5p is an oncogene in lung adenocarcinoma and facilitates tumor progression through ARHGAP6 downregulation. | 8 |
| 30816546 | 2019 | ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells. | 11 |
| 30816546 | 2019 | ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells. | 11 |
| 23251683 | 2012 | Amelogenesis imperfecta in two families with defined AMELX deletions in ARHGAP6. | 12 |
| 23251683 | 2012 | Amelogenesis imperfecta in two families with defined AMELX deletions in ARHGAP6. | 12 |
| 19960375 | 2010 | Identification of Rho GTPase activating protein 6 isoform 1 variant as a new molecular marker in human colorectal tumors. | 5 |
| 20628086 | 2010 | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. | 15 |
| 19960375 | 2010 | Identification of Rho GTPase activating protein 6 isoform 1 variant as a new molecular marker in human colorectal tumors. | 5 |
Citation
Dessen P
ARHGAP6 (Rho GTPase activating protein 6)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/697/arhgap6
