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ARHGAP6 (Rho GTPase activating protein 6)

Identity

Alias_symbol (synonym)rhoGAPX-1
Other aliasRHOGAP6
RHOGAPX-1
HGNC (Hugo) ARHGAP6
LocusID (NCBI) 395
Atlas_Id 697
Location Xp22.2  [Link to chromosome band Xp22]
Location_base_pair Starts at 11137543 and ends at 11427785 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ARHGAP6 (Xp22.2) / BACH2 (6q15)ARHGAP6 (Xp22.2) / MBD1 (18q21.1)ARHGAP6 (Xp22.2) / PRCC (1q23.1)
CLDN18 (3q22.3) / ARHGAP6 (Xp22.2)MID1 (Xp22.2) / ARHGAP6 (Xp22.2)PSD4 (2q13) / ARHGAP6 (Xp22.2)
MID1 Xp22.2 / ARHGAP6 Xp22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGAP6   676
Cards
Entrez_Gene (NCBI)ARHGAP6  395  Rho GTPase activating protein 6
AliasesRHOGAP6; RHOGAPX-1
GeneCards (Weizmann)ARHGAP6
Ensembl hg19 (Hinxton)ENSG00000047648 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000047648 [Gene_View]  chrX:11137543-11427785 [Contig_View]  ARHGAP6 [Vega]
ICGC DataPortalENSG00000047648
TCGA cBioPortalARHGAP6
AceView (NCBI)ARHGAP6
Genatlas (Paris)ARHGAP6
WikiGenes395
SOURCE (Princeton)ARHGAP6
Genetics Home Reference (NIH)ARHGAP6
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP6  -     chrX:11137543-11427785 -  Xp22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP6  -     Xp22.2   [Description]    (hg19-Feb_2009)
EnsemblARHGAP6 - Xp22.2 [CytoView hg19]  ARHGAP6 - Xp22.2 [CytoView hg38]
Mapping of homologs : NCBIARHGAP6 [Mapview hg19]  ARHGAP6 [Mapview hg38]
OMIM300118   
Gene and transcription
Genbank (Entrez)AB208792 AF012272 AF022212 AF117067 AF177663
RefSeq transcript (Entrez)NM_001174 NM_001287242 NM_006125 NM_013422 NM_013423 NM_013427
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP6
Cluster EST : UnigeneHs.435291 [ NCBI ]
CGAP (NCI)Hs.435291
Alternative Splicing GalleryENSG00000047648
Gene ExpressionARHGAP6 [ NCBI-GEO ]   ARHGAP6 [ EBI - ARRAY_EXPRESS ]   ARHGAP6 [ SEEK ]   ARHGAP6 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)395
GTEX Portal (Tissue expression)ARHGAP6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43182   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43182  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43182
Splice isoforms : SwissVarO43182
PhosPhoSitePlusO43182
Domaine pattern : Prosite (Expaxy)RHOGAP (PS50238)   
Domains : Interpro (EBI)Rho_GTPase_activation_prot    RhoGAP6    RhoGAP_dom   
Domain families : Pfam (Sanger)RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam00620   
Domain families : Smart (EMBL)RhoGAP (SM00324)  
Conserved Domain (NCBI)ARHGAP6
DMDM Disease mutations395
Blocks (Seattle)ARHGAP6
SuperfamilyO43182
Human Protein AtlasENSG00000047648
Peptide AtlasO43182
HPRD02124
IPIIPI00011219   IPI00221121   IPI00221122   IPI00221123   IPI00872679   IPI00910889   IPI01009385   IPI00942333   
Protein Interaction databases
DIP (DOE-UCLA)O43182
IntAct (EBI)O43182
FunCoupENSG00000047648
BioGRIDARHGAP6
STRING (EMBL)ARHGAP6
ZODIACARHGAP6
Ontologies - Pathways
QuickGOO43182
Ontology : AmiGOSH3/SH2 adaptor activity  GTPase activator activity  cytoplasm  cytosol  actin filament  Rho protein signal transduction  positive regulation of signal transduction  actin cytoskeleton  SH3 domain binding  actin filament polymerization  positive regulation of GTPase activity  focal adhesion assembly  regulation of small GTPase mediated signal transduction  negative regulation of stress fiber assembly  negative regulation of focal adhesion assembly  
Ontology : EGO-EBISH3/SH2 adaptor activity  GTPase activator activity  cytoplasm  cytosol  actin filament  Rho protein signal transduction  positive regulation of signal transduction  actin cytoskeleton  SH3 domain binding  actin filament polymerization  positive regulation of GTPase activity  focal adhesion assembly  regulation of small GTPase mediated signal transduction  negative regulation of stress fiber assembly  negative regulation of focal adhesion assembly  
Pathways : BIOCARTARho cell motility signaling pathway [Genes]   
NDEx NetworkARHGAP6
Atlas of Cancer Signalling NetworkARHGAP6
Wikipedia pathwaysARHGAP6
Orthology - Evolution
OrthoDB395
GeneTree (enSembl)ENSG00000047648
Phylogenetic Trees/Animal Genes : TreeFamARHGAP6
HOVERGENO43182
HOGENOMO43182
Homologs : HomoloGeneARHGAP6
Homology/Alignments : Family Browser (UCSC)ARHGAP6
Gene fusions - Rearrangements
Fusion : MitelmanCLDN18/ARHGAP6 [3q22.3/Xp22.2]  [t(X;3)(p22;q22)]  
Fusion : MitelmanMID1/ARHGAP6 [Xp22.2/Xp22.2]  [t(X;X)(p22;p22)]  
Fusion: TCGAMID1 Xp22.2 ARHGAP6 Xp22.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP6
dbVarARHGAP6
ClinVarARHGAP6
1000_GenomesARHGAP6 
Exome Variant ServerARHGAP6
ExAC (Exome Aggregation Consortium)ARHGAP6 (select the gene name)
Genetic variants : HAPMAP395
Genomic Variants (DGV)ARHGAP6 [DGVbeta]
DECIPHERARHGAP6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP6 
Mutations
ICGC Data PortalARHGAP6 
TCGA Data PortalARHGAP6 
Broad Tumor PortalARHGAP6
OASIS PortalARHGAP6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch ARHGAP6
DgiDB (Drug Gene Interaction Database)ARHGAP6
DoCM (Curated mutations)ARHGAP6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP6 (select a term)
intoGenARHGAP6
Cancer3DARHGAP6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300118   
Orphanet
MedgenARHGAP6
Genetic Testing Registry ARHGAP6
NextProtO43182 [Medical]
TSGene395
GENETestsARHGAP6
Huge Navigator ARHGAP6 [HugePedia]
snp3D : Map Gene to Disease395
BioCentury BCIQARHGAP6
ClinGenARHGAP6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD395
Chemical/Pharm GKB GenePA24960
Clinical trialARHGAP6
Miscellaneous
canSAR (ICR)ARHGAP6 (select the gene name)
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP6
EVEXARHGAP6
GoPubMedARHGAP6
iHOPARHGAP6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:06:34 CEST 2017

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