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ARHGAP8 (Rho GTPase activating protein 8)

Identity

Alias_symbol (synonym)FLJ20185
BPGAP1
Other aliasPP610
HGNC (Hugo) ARHGAP8
LocusID (NCBI) 23779
Atlas_Id 43142
Location 22q13.31  [Link to chromosome band 22q13]
Location_base_pair Starts at 44752558 and ends at 44862784 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGAP8 (22q13.31) / ACLY (17q21.2)ARHGAP8 (22q13.31) / GTPBP4 (10p15.3)PRR5 (22q13.31) / ARHGAP8 (22q13.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)ARHGAP8   677
Cards
Entrez_Gene (NCBI)ARHGAP8  23779  Rho GTPase activating protein 8
AliasesBPGAP1; PP610
GeneCards (Weizmann)ARHGAP8
Ensembl hg19 (Hinxton)ENSG00000241484 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000241484 [Gene_View]  ENSG00000241484 [Sequence]  chr22:44752558-44862784 [Contig_View]  ARHGAP8 [Vega]
ICGC DataPortalENSG00000241484
TCGA cBioPortalARHGAP8
AceView (NCBI)ARHGAP8
Genatlas (Paris)ARHGAP8
WikiGenes23779
SOURCE (Princeton)ARHGAP8
Genetics Home Reference (NIH)ARHGAP8
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGAP8  -     chr22:44752558-44862784 +  22q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGAP8  -     22q13.31   [Description]    (hg19-Feb_2009)
EnsemblARHGAP8 - 22q13.31 [CytoView hg19]  ARHGAP8 - 22q13.31 [CytoView hg38]
Mapping of homologs : NCBIARHGAP8 [Mapview hg19]  ARHGAP8 [Mapview hg38]
OMIM609405   
Gene and transcription
Genbank (Entrez)AF544240 AI284954 AK001306 AK022305 AW673723
RefSeq transcript (Entrez)NM_001017526 NM_001198726 NM_181335
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGAP8
Cluster EST : UnigeneHs.102336 [ NCBI ]
CGAP (NCI)Hs.102336
Alternative Splicing GalleryENSG00000241484
Gene ExpressionARHGAP8 [ NCBI-GEO ]   ARHGAP8 [ EBI - ARRAY_EXPRESS ]   ARHGAP8 [ SEEK ]   ARHGAP8 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGAP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23779
GTEX Portal (Tissue expression)ARHGAP8
Human Protein AtlasENSG00000241484-ARHGAP8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP85298   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP85298  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP85298
Splice isoforms : SwissVarP85298
PhosPhoSitePlusP85298
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)    RHOGAP (PS50238)   
Domains : Interpro (EBI)CRAL-TRIO_dom    Rho_GTPase_activation_prot    RhoGAP_dom   
Domain families : Pfam (Sanger)CRAL_TRIO_2 (PF13716)    RhoGAP (PF00620)   
Domain families : Pfam (NCBI)pfam13716    pfam00620   
Domain families : Smart (EMBL)RhoGAP (SM00324)  SEC14 (SM00516)  
Conserved Domain (NCBI)ARHGAP8
DMDM Disease mutations23779
Blocks (Seattle)ARHGAP8
SuperfamilyP85298
Human Protein Atlas [tissue]ENSG00000241484-ARHGAP8 [tissue]
Peptide AtlasP85298
HPRD06448
Protein Interaction databases
DIP (DOE-UCLA)P85298
IntAct (EBI)P85298
FunCoupENSG00000241484
BioGRIDARHGAP8
STRING (EMBL)ARHGAP8
ZODIACARHGAP8
Ontologies - Pathways
QuickGOP85298
Ontology : AmiGOGTPase activator activity  GTPase activator activity  protein binding  cytoplasm  cytosol  signal transduction  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  positive regulation of ERK1 and ERK2 cascade  
Ontology : EGO-EBIGTPase activator activity  GTPase activator activity  protein binding  cytoplasm  cytosol  signal transduction  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  positive regulation of ERK1 and ERK2 cascade  
NDEx NetworkARHGAP8
Atlas of Cancer Signalling NetworkARHGAP8
Wikipedia pathwaysARHGAP8
Orthology - Evolution
OrthoDB23779
GeneTree (enSembl)ENSG00000241484
Phylogenetic Trees/Animal Genes : TreeFamARHGAP8
HOVERGENP85298
HOGENOMP85298
Homologs : HomoloGeneARHGAP8
Homology/Alignments : Family Browser (UCSC)ARHGAP8
Gene fusions - Rearrangements
Fusion : QuiverARHGAP8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGAP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGAP8
dbVarARHGAP8
ClinVarARHGAP8
1000_GenomesARHGAP8 
Exome Variant ServerARHGAP8
ExAC (Exome Aggregation Consortium)ENSG00000241484
GNOMAD BrowserENSG00000241484
Genetic variants : HAPMAP23779
Genomic Variants (DGV)ARHGAP8 [DGVbeta]
DECIPHERARHGAP8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGAP8 
Mutations
ICGC Data PortalARHGAP8 
TCGA Data PortalARHGAP8 
Broad Tumor PortalARHGAP8
OASIS PortalARHGAP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGAP8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGAP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGAP8
DgiDB (Drug Gene Interaction Database)ARHGAP8
DoCM (Curated mutations)ARHGAP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGAP8 (select a term)
intoGenARHGAP8
Cancer3DARHGAP8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609405   
Orphanet
DisGeNETARHGAP8
MedgenARHGAP8
Genetic Testing Registry ARHGAP8
NextProtP85298 [Medical]
TSGene23779
GENETestsARHGAP8
Target ValidationARHGAP8
Huge Navigator ARHGAP8 [HugePedia]
snp3D : Map Gene to Disease23779
BioCentury BCIQARHGAP8
ClinGenARHGAP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23779
Chemical/Pharm GKB GenePA24961
Clinical trialARHGAP8
Miscellaneous
canSAR (ICR)ARHGAP8 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGAP8
EVEXARHGAP8
GoPubMedARHGAP8
iHOPARHGAP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:14:47 CEST 2018
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