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ARHGDIA (Rho GDP dissociation inhibitor alpha)

Identity

Alias (NCBI)GDIA1
HEL-S-47e
NPHS8
RHOGDI
RHOGDI-1
HGNC (Hugo) ARHGDIA
HGNC Alias symbRHOGDI
HGNC Previous nameGDIA1
HGNC Previous nameRho GDP dissociation inhibitor (GDI) alpha
LocusID (NCBI) 396
Atlas_Id 50596
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 81867721 and ends at 81871337 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGDIA (17q25.3) / RNF213 (17q25.3)ARHGDIA (17q25.3) / SQSTM1 (5q35.3)ARHGDIA 17q25.3 / RNF213 17q25.3
ARHGDIA 17q25.3 / SQSTM1 5q35.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ARHGDIA   678
Cards
Entrez_Gene (NCBI)ARHGDIA    Rho GDP dissociation inhibitor alpha
AliasesGDIA1; HEL-S-47e; NPHS8; RHOGDI; 
RHOGDI-1
GeneCards (Weizmann)ARHGDIA
Ensembl hg19 (Hinxton)ENSG00000141522 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141522 [Gene_View]  ENSG00000141522 [Sequence]  chr17:81867721-81871337 [Contig_View]  ARHGDIA [Vega]
ICGC DataPortalENSG00000141522
TCGA cBioPortalARHGDIA
AceView (NCBI)ARHGDIA
Genatlas (Paris)ARHGDIA
SOURCE (Princeton)ARHGDIA
Genetics Home Reference (NIH)ARHGDIA
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGDIA  -     chr17:81867721-81871337 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGDIA  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathARHGDIA - 17q25.3 [CytoView hg19]  ARHGDIA - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000141522
Genome Data Viewer NCBIARHGDIA [Mapview hg19]  
OMIM601925   615244   
Gene and transcription
Genbank (Entrez)AF498926 AI391750 AI751683 AK293147 AK300816
RefSeq transcript (Entrez)NM_001185077 NM_001185078 NM_001301240 NM_001301241 NM_001301242 NM_001301243 NM_004309
Consensus coding sequences : CCDS (NCBI)ARHGDIA
Gene ExpressionARHGDIA [ NCBI-GEO ]   ARHGDIA [ EBI - ARRAY_EXPRESS ]   ARHGDIA [ SEEK ]   ARHGDIA [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGDIA [ Firebrowse - Broad ]
GenevisibleExpression of ARHGDIA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)396
GTEX Portal (Tissue expression)ARHGDIA
Human Protein AtlasENSG00000141522-ARHGDIA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52565   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52565  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52565
PhosPhoSitePlusP52565
Domains : Interpro (EBI)Ig_E-set    Rho_GDI    RhoGDI_dom_sf   
Domain families : Pfam (Sanger)Rho_GDI (PF02115)   
Domain families : Pfam (NCBI)pfam02115   
Conserved Domain (NCBI)ARHGDIA
PDB (RSDB)1CC0    1FSO    1FST    1FT0    1FT3    1HH4    1KMT    1QVY    1RHO    2BXW    2JHS    2JHT    2JHU    2JHV    2JHW    2JHX    2JHY    2JHZ    2JI0    2N80   
PDB Europe1CC0    1FSO    1FST    1FT0    1FT3    1HH4    1KMT    1QVY    1RHO    2BXW    2JHS    2JHT    2JHU    2JHV    2JHW    2JHX    2JHY    2JHZ    2JI0    2N80   
PDB (PDBSum)1CC0    1FSO    1FST    1FT0    1FT3    1HH4    1KMT    1QVY    1RHO    2BXW    2JHS    2JHT    2JHU    2JHV    2JHW    2JHX    2JHY    2JHZ    2JI0    2N80   
PDB (IMB)1CC0    1FSO    1FST    1FT0    1FT3    1HH4    1KMT    1QVY    1RHO    2BXW    2JHS    2JHT    2JHU    2JHV    2JHW    2JHX    2JHY    2JHZ    2JI0    2N80   
Structural Biology KnowledgeBase1CC0    1FSO    1FST    1FT0    1FT3    1HH4    1KMT    1QVY    1RHO    2BXW    2JHS    2JHT    2JHU    2JHV    2JHW    2JHX    2JHY    2JHZ    2JI0    2N80   
SCOP (Structural Classification of Proteins)1CC0    1FSO    1FST    1FT0    1FT3    1HH4    1KMT    1QVY    1RHO    2BXW    2JHS    2JHT    2JHU    2JHV    2JHW    2JHX    2JHY    2JHZ    2JI0    2N80   
CATH (Classification of proteins structures)1CC0    1FSO    1FST    1FT0    1FT3    1HH4    1KMT    1QVY    1RHO    2BXW    2JHS    2JHT    2JHU    2JHV    2JHW    2JHX    2JHY    2JHZ    2JI0    2N80   
SuperfamilyP52565
AlphaFold pdb e-kbP52565   
Human Protein Atlas [tissue]ENSG00000141522-ARHGDIA [tissue]
HPRD03565
Protein Interaction databases
DIP (DOE-UCLA)P52565
IntAct (EBI)P52565
BioGRIDARHGDIA
STRING (EMBL)ARHGDIA
ZODIACARHGDIA
Ontologies - Pathways
QuickGOP52565
Ontology : AmiGOimmunological synapse  Rho GDP-dissociation inhibitor activity  GTPase activator activity  fatty acid binding  protein binding  nucleus  cytosol  cytosol  cytoskeleton  negative regulation of cell adhesion  Rho protein signal transduction  regulation of cell shape  membrane  protein kinase binding  negative regulation of cell migration  small GTPase binding  regulation of protein localization  regulation of Rho protein signal transduction  negative regulation of apoptotic process  synapse  negative regulation of axonogenesis  positive regulation of axonogenesis  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  Hsp90 protein binding  extracellular exosome  cellular response to mechanical stimulus  cellular response to organic cyclic compound  cellular response to redox state  semaphorin-plexin signaling pathway  regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIimmunological synapse  Rho GDP-dissociation inhibitor activity  GTPase activator activity  fatty acid binding  protein binding  nucleus  cytosol  cytosol  cytoskeleton  negative regulation of cell adhesion  Rho protein signal transduction  regulation of cell shape  membrane  protein kinase binding  negative regulation of cell migration  small GTPase binding  regulation of protein localization  regulation of Rho protein signal transduction  negative regulation of apoptotic process  synapse  negative regulation of axonogenesis  positive regulation of axonogenesis  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  Hsp90 protein binding  extracellular exosome  cellular response to mechanical stimulus  cellular response to organic cyclic compound  cellular response to redox state  semaphorin-plexin signaling pathway  regulation of actin cytoskeleton reorganization  
Pathways : KEGGNeurotrophin signaling pathway    Vasopressin-regulated water reabsorption   
NDEx NetworkARHGDIA
Atlas of Cancer Signalling NetworkARHGDIA
Wikipedia pathwaysARHGDIA
Orthology - Evolution
OrthoDB396
GeneTree (enSembl)ENSG00000141522
Phylogenetic Trees/Animal Genes : TreeFamARHGDIA
Homologs : HomoloGeneARHGDIA
Homology/Alignments : Family Browser (UCSC)ARHGDIA
Gene fusions - Rearrangements
Fusion : MitelmanARHGDIA/RNF213 [17q25.3/17q25.3]  
Fusion : MitelmanARHGDIA/SQSTM1 [17q25.3/5q35.3]  
Fusion : QuiverARHGDIA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGDIA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGDIA
dbVarARHGDIA
ClinVarARHGDIA
MonarchARHGDIA
1000_GenomesARHGDIA 
Exome Variant ServerARHGDIA
GNOMAD BrowserENSG00000141522
Varsome BrowserARHGDIA
ACMGARHGDIA variants
VarityP52565
Genomic Variants (DGV)ARHGDIA [DGVbeta]
DECIPHERARHGDIA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGDIA 
Mutations
ICGC Data PortalARHGDIA 
TCGA Data PortalARHGDIA 
Broad Tumor PortalARHGDIA
OASIS PortalARHGDIA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGDIA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DARHGDIA
Mutations and Diseases : HGMDARHGDIA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaARHGDIA
DgiDB (Drug Gene Interaction Database)ARHGDIA
DoCM (Curated mutations)ARHGDIA
CIViC (Clinical Interpretations of Variants in Cancer)ARHGDIA
Cancer3DARHGDIA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601925    615244   
Orphanet12194   
DisGeNETARHGDIA
MedgenARHGDIA
Genetic Testing Registry ARHGDIA
NextProtP52565 [Medical]
GENETestsARHGDIA
Target ValidationARHGDIA
Huge Navigator ARHGDIA [HugePedia]
ClinGenARHGDIA
Clinical trials, drugs, therapy
MyCancerGenomeARHGDIA
Protein Interactions : CTDARHGDIA
Pharm GKB GenePA24963
PharosP52565
Clinical trialARHGDIA
Miscellaneous
canSAR (ICR)ARHGDIA
HarmonizomeARHGDIA
DataMed IndexARHGDIA
Probes
Litterature
PubMed168 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXARHGDIA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:00:00 CEST 2021

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