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ARHGDIB (Rho GDP dissociation inhibitor beta)

Identity

Alias_namesRAP1GN1
GDIA2
GDID4
Rho GDP dissociation inhibitor (GDI) beta
Alias_symbol (synonym)Ly-GDI
RhoGDI2
Other aliasD4
LYGDI
HGNC (Hugo) ARHGDIB
LocusID (NCBI) 397
Atlas_Id 49851
Location 12p12.3  [Link to chromosome band 12p12]
Location_base_pair Starts at 15094950 and ends at 15114562 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARHGDIB (12p12.3) / ARHGDIB (12p12.3)ARHGDIB (12p12.3) / CASQ2 (1p13.1)ARHGDIB (12p12.3) / ENO1 (1p36.23)
ARHGDIB (12p12.3) / RP11-677C1.2 ()PITPNB (22q12.1) / ARHGDIB (12p12.3)ARHGDIB 12p12.3 RP11-677C1.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGDIB   679
Cards
Entrez_Gene (NCBI)ARHGDIB  397  Rho GDP dissociation inhibitor beta
AliasesD4; GDIA2; GDID4; LYGDI; 
Ly-GDI; RAP1GN1; RhoGDI2
GeneCards (Weizmann)ARHGDIB
Ensembl hg19 (Hinxton)ENSG00000111348 [Gene_View]  chr12:15094950-15114562 [Contig_View]  ARHGDIB [Vega]
Ensembl hg38 (Hinxton)ENSG00000111348 [Gene_View]  chr12:15094950-15114562 [Contig_View]  ARHGDIB [Vega]
ICGC DataPortalENSG00000111348
TCGA cBioPortalARHGDIB
AceView (NCBI)ARHGDIB
Genatlas (Paris)ARHGDIB
WikiGenes397
SOURCE (Princeton)ARHGDIB
Genetics Home Reference (NIH)ARHGDIB
Genomic and cartography
GoldenPath hg19 (UCSC)ARHGDIB  -     chr12:15094950-15114562 -  12p12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ARHGDIB  -     12p12.3   [Description]    (hg38-Dec_2013)
EnsemblARHGDIB - 12p12.3 [CytoView hg19]  ARHGDIB - 12p12.3 [CytoView hg38]
Mapping of homologs : NCBIARHGDIB [Mapview hg19]  ARHGDIB [Mapview hg38]
OMIM602843   
Gene and transcription
Genbank (Entrez)AA143425 AB451315 AB451445 AF498927 AK311807
RefSeq transcript (Entrez)NM_001175 NM_001321420 NM_001321421 NM_001321422 NM_001321423
RefSeq genomic (Entrez)NC_000012 NC_018923 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)ARHGDIB
Cluster EST : UnigeneHs.504877 [ NCBI ]
CGAP (NCI)Hs.504877
Alternative Splicing GalleryENSG00000111348
Gene ExpressionARHGDIB [ NCBI-GEO ]   ARHGDIB [ EBI - ARRAY_EXPRESS ]   ARHGDIB [ SEEK ]   ARHGDIB [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGDIB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)397
GTEX Portal (Tissue expression)ARHGDIB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52566   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52566  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52566
Splice isoforms : SwissVarP52566
PhosPhoSitePlusP52566
Domains : Interpro (EBI)Ig_E-set    Rho_GDI    RhoGDI_domain   
Domain families : Pfam (Sanger)Rho_GDI (PF02115)   
Domain families : Pfam (NCBI)pfam02115   
Conserved Domain (NCBI)ARHGDIB
DMDM Disease mutations397
Blocks (Seattle)ARHGDIB
PDB (SRS)1DS6   
PDB (PDBSum)1DS6   
PDB (IMB)1DS6   
PDB (RSDB)1DS6   
Structural Biology KnowledgeBase1DS6   
SCOP (Structural Classification of Proteins)1DS6   
CATH (Classification of proteins structures)1DS6   
SuperfamilyP52566
Human Protein AtlasENSG00000111348
Peptide AtlasP52566
HPRD04162
IPIIPI00003817   IPI01015187   IPI01011820   IPI01013112   IPI01012413   
Protein Interaction databases
DIP (DOE-UCLA)P52566
IntAct (EBI)P52566
FunCoupENSG00000111348
BioGRIDARHGDIB
STRING (EMBL)ARHGDIB
ZODIACARHGDIB
Ontologies - Pathways
QuickGOP52566
Ontology : AmiGOGTPase activity  Rho GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  cytoplasm  cytosol  cytosol  cytoskeleton  movement of cell or subcellular component  negative regulation of cell adhesion  multicellular organism development  membrane  cytoplasmic, membrane-bounded vesicle  regulation of Rho protein signal transduction  regulation of Rho protein signal transduction  positive regulation of GTPase activity  Rac GTPase binding  regulation of catalytic activity  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  extracellular exosome  cellular response to redox state  negative regulation of trophoblast cell migration  regulation of actin cytoskeleton reorganization  
Ontology : EGO-EBIGTPase activity  Rho GDP-dissociation inhibitor activity  GTPase activator activity  protein binding  cytoplasm  cytosol  cytosol  cytoskeleton  movement of cell or subcellular component  negative regulation of cell adhesion  multicellular organism development  membrane  cytoplasmic, membrane-bounded vesicle  regulation of Rho protein signal transduction  regulation of Rho protein signal transduction  positive regulation of GTPase activity  Rac GTPase binding  regulation of catalytic activity  regulation of catalytic activity  regulation of small GTPase mediated signal transduction  extracellular exosome  cellular response to redox state  negative regulation of trophoblast cell migration  regulation of actin cytoskeleton reorganization  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    TNFR1 Signaling Pathway [Genes]    Caspase Cascade in Apoptosis [Genes]    D4-GDI Signaling Pathway [Genes]   
Pathways : KEGGNeurotrophin signaling pathway    Vasopressin-regulated water reabsorption   
NDEx NetworkARHGDIB
Atlas of Cancer Signalling NetworkARHGDIB
Wikipedia pathwaysARHGDIB
Orthology - Evolution
OrthoDB397
GeneTree (enSembl)ENSG00000111348
Phylogenetic Trees/Animal Genes : TreeFamARHGDIB
HOVERGENP52566
HOGENOMP52566
Homologs : HomoloGeneARHGDIB
Homology/Alignments : Family Browser (UCSC)ARHGDIB
Gene fusions - Rearrangements
Fusion: TCGAARHGDIB 12p12.3 RP11-677C1.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGDIB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGDIB
dbVarARHGDIB
ClinVarARHGDIB
1000_GenomesARHGDIB 
Exome Variant ServerARHGDIB
ExAC (Exome Aggregation Consortium)ARHGDIB (select the gene name)
Genetic variants : HAPMAP397
Genomic Variants (DGV)ARHGDIB [DGVbeta]
DECIPHER (Syndromes)12:15094950-15114562  ENSG00000111348
CONAN: Copy Number AnalysisARHGDIB 
Mutations
ICGC Data PortalARHGDIB 
TCGA Data PortalARHGDIB 
Broad Tumor PortalARHGDIB
OASIS PortalARHGDIB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGDIB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGDIB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGDIB
DgiDB (Drug Gene Interaction Database)ARHGDIB
DoCM (Curated mutations)ARHGDIB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGDIB (select a term)
intoGenARHGDIB
Cancer3DARHGDIB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602843   
Orphanet
MedgenARHGDIB
Genetic Testing Registry ARHGDIB
NextProtP52566 [Medical]
TSGene397
GENETestsARHGDIB
Huge Navigator ARHGDIB [HugePedia]
snp3D : Map Gene to Disease397
BioCentury BCIQARHGDIB
ClinGenARHGDIB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD397
Chemical/Pharm GKB GenePA24964
Clinical trialARHGDIB
Miscellaneous
canSAR (ICR)ARHGDIB (select the gene name)
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGDIB
EVEXARHGDIB
GoPubMedARHGDIB
iHOPARHGDIB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:56:24 CET 2017

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