ARHGEF1 (Rho guanine nucleotide exchange factor 1)

2003-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
GEF1,IMD62,LBCL2,LSC,P115-RHOGEF,SUB1.5
FUSION GENES

Other Information

Locus ID:

NCBI: 9138
MIM: 601855
HGNC: 681
Ensembl: ENSG00000076928

Variants:

dbSNP: 9138
ClinVar: 9138
TCGA: ENSG00000076928
COSMIC: ARHGEF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076928ENST00000337665Q92888
ENSG00000076928ENST00000347545Q92888
ENSG00000076928ENST00000354532Q92888
ENSG00000076928ENST00000354532A0A024R0R1
ENSG00000076928ENST00000378152Q92888
ENSG00000076928ENST00000594258M0QYS3
ENSG00000076928ENST00000594417M0R1K8
ENSG00000076928ENST00000594521M0QZH8
ENSG00000076928ENST00000595723M0R2C7
ENSG00000076928ENST00000598812M0R3H5
ENSG00000076928ENST00000599589M0QYC1
ENSG00000076928ENST00000599846M0QZR4
ENSG00000076928ENST00000600517M0QXV6

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Platelet activationKEGGhsa04611
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth inhibition (RHOA activation)REACTOMER-HSA-193634
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
127481842003Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.78
197208752009P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium.60
127542112003Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement.50
214544922011Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).31
230706842012miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.31
151430722004Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells.28
123725942002B plexins activate Rho through PDZ-RhoGEF.27
210641652011Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.21
125254882003Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF.19

Citation

Dessen P

ARHGEF1 (Rho guanine nucleotide exchange factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/698/arhgef1