Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARHGEF15 (Rho guanine nucleotide exchange factor 15)

Identity

Alias_namesRho guanine nucleotide exchange factor (GEF) 15
Alias_symbol (synonym)KIAA0915
Vsm-RhoGEF
ARGEF15
FLJ13791
MGC44868
Other aliasE5
Ephexin5
HGNC (Hugo) ARHGEF15
LocusID (NCBI) 22899
Atlas_Id 42989
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 8310822 and ends at 8322516 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF15 (17p13.1) / ARHGEF15 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGEF15   15590
Cards
Entrez_Gene (NCBI)ARHGEF15  22899  Rho guanine nucleotide exchange factor 15
AliasesARGEF15; E5; Ephexin5; Vsm-RhoGEF
GeneCards (Weizmann)ARHGEF15
Ensembl hg19 (Hinxton)ENSG00000198844 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198844 [Gene_View]  chr17:8310822-8322516 [Contig_View]  ARHGEF15 [Vega]
ICGC DataPortalENSG00000198844
TCGA cBioPortalARHGEF15
AceView (NCBI)ARHGEF15
Genatlas (Paris)ARHGEF15
WikiGenes22899
SOURCE (Princeton)ARHGEF15
Genetics Home Reference (NIH)ARHGEF15
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGEF15  -     chr17:8310822-8322516 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGEF15  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblARHGEF15 - 17p13.1 [CytoView hg19]  ARHGEF15 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIARHGEF15 [Mapview hg19]  ARHGEF15 [Mapview hg38]
OMIM608504   
Gene and transcription
Genbank (Entrez)AB020722 AK023853 AK291626 AK300327 AL601528
RefSeq transcript (Entrez)NM_025014 NM_173728
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGEF15
Cluster EST : UnigeneHs.443109 [ NCBI ]
CGAP (NCI)Hs.443109
Alternative Splicing GalleryENSG00000198844
Gene ExpressionARHGEF15 [ NCBI-GEO ]   ARHGEF15 [ EBI - ARRAY_EXPRESS ]   ARHGEF15 [ SEEK ]   ARHGEF15 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGEF15 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22899
GTEX Portal (Tissue expression)ARHGEF15
Human Protein AtlasENSG00000198844-ARHGEF15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94989   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94989  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94989
Splice isoforms : SwissVarO94989
PhosPhoSitePlusO94989
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)   
Domains : Interpro (EBI)DH-domain    PH_dom-like   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)RhoGEF (SM00325)  
Conserved Domain (NCBI)ARHGEF15
DMDM Disease mutations22899
Blocks (Seattle)ARHGEF15
SuperfamilyO94989
Human Protein Atlas [tissue]ENSG00000198844-ARHGEF15 [tissue]
Peptide AtlasO94989
HPRD10535
IPIIPI00455852   IPI00909033   
Protein Interaction databases
DIP (DOE-UCLA)O94989
IntAct (EBI)O94989
FunCoupENSG00000198844
BioGRIDARHGEF15
STRING (EMBL)ARHGEF15
ZODIACARHGEF15
Ontologies - Pathways
QuickGOO94989
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytoplasm  dendrite  regulation of Rho protein signal transduction  positive regulation of GTPase activity  regulation of catalytic activity  positive regulation of stress fiber assembly  retina vasculature morphogenesis in camera-type eye  negative regulation of synapse maturation  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytoplasm  dendrite  regulation of Rho protein signal transduction  positive regulation of GTPase activity  regulation of catalytic activity  positive regulation of stress fiber assembly  retina vasculature morphogenesis in camera-type eye  negative regulation of synapse maturation  
NDEx NetworkARHGEF15
Atlas of Cancer Signalling NetworkARHGEF15
Wikipedia pathwaysARHGEF15
Orthology - Evolution
OrthoDB22899
GeneTree (enSembl)ENSG00000198844
Phylogenetic Trees/Animal Genes : TreeFamARHGEF15
HOVERGENO94989
HOGENOMO94989
Homologs : HomoloGeneARHGEF15
Homology/Alignments : Family Browser (UCSC)ARHGEF15
Gene fusions - Rearrangements
Tumor Fusion PortalARHGEF15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGEF15 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGEF15
dbVarARHGEF15
ClinVarARHGEF15
1000_GenomesARHGEF15 
Exome Variant ServerARHGEF15
ExAC (Exome Aggregation Consortium)ENSG00000198844
GNOMAD BrowserENSG00000198844
Genetic variants : HAPMAP22899
Genomic Variants (DGV)ARHGEF15 [DGVbeta]
DECIPHERARHGEF15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGEF15 
Mutations
ICGC Data PortalARHGEF15 
TCGA Data PortalARHGEF15 
Broad Tumor PortalARHGEF15
OASIS PortalARHGEF15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGEF15  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGEF15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGEF15
DgiDB (Drug Gene Interaction Database)ARHGEF15
DoCM (Curated mutations)ARHGEF15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGEF15 (select a term)
intoGenARHGEF15
Cancer3DARHGEF15(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608504   
Orphanet
DisGeNETARHGEF15
MedgenARHGEF15
Genetic Testing Registry ARHGEF15
NextProtO94989 [Medical]
TSGene22899
GENETestsARHGEF15
Target ValidationARHGEF15
Huge Navigator ARHGEF15 [HugePedia]
snp3D : Map Gene to Disease22899
BioCentury BCIQARHGEF15
ClinGenARHGEF15
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22899
Chemical/Pharm GKB GenePA24970
Clinical trialARHGEF15
Miscellaneous
canSAR (ICR)ARHGEF15 (select the gene name)
Probes
Litterature
PubMed15 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGEF15
EVEXARHGEF15
GoPubMedARHGEF15
iHOPARHGEF15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:03:39 CET 2017

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