ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)

2006-10-01  

Identity

HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
P114-RhoGEF,RP78,SA-RhoGEF,p114RhoGEF
FUSION GENES

Other Information

Locus ID:

NCBI: 23370
MIM: 616432
HGNC: 17090
Ensembl: ENSG00000268861

Variants:

dbSNP: 23370
ClinVar: 23370
TCGA: ENSG00000268861
COSMIC: ARHGEF18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000268861ENST00000668164A0A590UK10

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)REACTOMER-HSA-2173791
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

References

Pubmed IDYearTitleCitations
212583692011Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis.96
145124432003G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production.43
220069502011Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF.34
236484822013LKB1 controls human bronchial epithelial morphogenesis through p114RhoGEF-dependent RhoA activation.24
208107872010Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.18
231855722012Stimulation of cortical myosin phosphorylation by p114RhoGEF drives cell migration and tumor cell invasion.18
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.7
262170162015CRB3A Controls the Morphology and Cohesion of Cancer Cells through Ehm2/p114RhoGEF-Dependent Signaling.7
281326932017Biallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.7
304058542018Association between a Single Nucleotide Polymorphism in the 3'-UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population.1

Citation

Dessen P

ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43148/arhgef18