Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ARHGEF19 (Rho guanine nucleotide exchange factor 19)

Identity

Alias_namesRho guanine nucleotide exchange factor (GEF) 19
Alias_symbol (synonym)FLJ33962
WGEF
Other alias
HGNC (Hugo) ARHGEF19
LocusID (NCBI) 128272
Atlas_Id 43149
Location 1p36.13  [Link to chromosome band 1p36]
Location_base_pair Starts at 16197854 and ends at 16212671 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF19 (1p36.13) / ANO7P1 ()EPHA2 (1p36.13) / ARHGEF19 (1p36.13)ARHGEF19 1p36.13 ANO7L1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGEF19   26604
Cards
Entrez_Gene (NCBI)ARHGEF19  128272  Rho guanine nucleotide exchange factor 19
AliasesWGEF
GeneCards (Weizmann)ARHGEF19
Ensembl hg19 (Hinxton)ENSG00000142632 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142632 [Gene_View]  chr1:16197854-16212671 [Contig_View]  ARHGEF19 [Vega]
ICGC DataPortalENSG00000142632
TCGA cBioPortalARHGEF19
AceView (NCBI)ARHGEF19
Genatlas (Paris)ARHGEF19
WikiGenes128272
SOURCE (Princeton)ARHGEF19
Genetics Home Reference (NIH)ARHGEF19
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGEF19  -     chr1:16197854-16212671 -  1p36.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGEF19  -     1p36.13   [Description]    (hg19-Feb_2009)
EnsemblARHGEF19 - 1p36.13 [CytoView hg19]  ARHGEF19 - 1p36.13 [CytoView hg38]
Mapping of homologs : NCBIARHGEF19 [Mapview hg19]  ARHGEF19 [Mapview hg38]
OMIM612496   
Gene and transcription
Genbank (Entrez)AF088037 AK091281 AK297707 AL137736 BC012982
RefSeq transcript (Entrez)NM_153213
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGEF19
Cluster EST : UnigeneHs.591532 [ NCBI ]
CGAP (NCI)Hs.591532
Alternative Splicing GalleryENSG00000142632
Gene ExpressionARHGEF19 [ NCBI-GEO ]   ARHGEF19 [ EBI - ARRAY_EXPRESS ]   ARHGEF19 [ SEEK ]   ARHGEF19 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGEF19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)128272
GTEX Portal (Tissue expression)ARHGEF19
Human Protein AtlasENSG00000142632-ARHGEF19 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IW93   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IW93  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IW93
Splice isoforms : SwissVarQ8IW93
PhosPhoSitePlusQ8IW93
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)    SH3 (PS50002)   
Domains : Interpro (EBI)DH-domain    PH_dom-like    PH_domain    SH3_domain   
Domain families : Pfam (Sanger)RhoGEF (PF00621)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00621    pfam14604   
Domain families : Smart (EMBL)PH (SM00233)  RhoGEF (SM00325)  SH3 (SM00326)  
Conserved Domain (NCBI)ARHGEF19
DMDM Disease mutations128272
Blocks (Seattle)ARHGEF19
SuperfamilyQ8IW93
Human Protein Atlas [tissue]ENSG00000142632-ARHGEF19 [tissue]
Peptide AtlasQ8IW93
HPRD10659
IPIIPI00642092   IPI00217197   IPI01013154   IPI00513885   IPI00644601   
Protein Interaction databases
DIP (DOE-UCLA)Q8IW93
IntAct (EBI)Q8IW93
FunCoupENSG00000142632
BioGRIDARHGEF19
STRING (EMBL)ARHGEF19
ZODIACARHGEF19
Ontologies - Pathways
QuickGOQ8IW93
Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytosol  G-protein coupled receptor signaling pathway  regulation of actin cytoskeleton organization  regulation of Rho protein signal transduction  wound healing  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  GTPase activator activity  protein binding  cytosol  G-protein coupled receptor signaling pathway  regulation of actin cytoskeleton organization  regulation of Rho protein signal transduction  wound healing  positive regulation of apoptotic process  positive regulation of GTPase activity  regulation of small GTPase mediated signal transduction  Wnt signaling pathway, planar cell polarity pathway  
NDEx NetworkARHGEF19
Atlas of Cancer Signalling NetworkARHGEF19
Wikipedia pathwaysARHGEF19
Orthology - Evolution
OrthoDB128272
GeneTree (enSembl)ENSG00000142632
Phylogenetic Trees/Animal Genes : TreeFamARHGEF19
HOVERGENQ8IW93
HOGENOMQ8IW93
Homologs : HomoloGeneARHGEF19
Homology/Alignments : Family Browser (UCSC)ARHGEF19
Gene fusions - Rearrangements
Fusion : MitelmanARHGEF19/ANO7P1 [1p36.13/-]  
Fusion: TCGA_MDACCARHGEF19 1p36.13 ANO7L1 BRCA
Fusion PortalARHGEF19 1p36.13 ANO7L1 BRCA
Fusion : QuiverARHGEF19
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGEF19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGEF19
dbVarARHGEF19
ClinVarARHGEF19
1000_GenomesARHGEF19 
Exome Variant ServerARHGEF19
ExAC (Exome Aggregation Consortium)ENSG00000142632
GNOMAD BrowserENSG00000142632
Genetic variants : HAPMAP128272
Genomic Variants (DGV)ARHGEF19 [DGVbeta]
DECIPHERARHGEF19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGEF19 
Mutations
ICGC Data PortalARHGEF19 
TCGA Data PortalARHGEF19 
Broad Tumor PortalARHGEF19
OASIS PortalARHGEF19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGEF19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGEF19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGEF19
DgiDB (Drug Gene Interaction Database)ARHGEF19
DoCM (Curated mutations)ARHGEF19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGEF19 (select a term)
intoGenARHGEF19
Cancer3DARHGEF19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612496   
Orphanet
DisGeNETARHGEF19
MedgenARHGEF19
Genetic Testing Registry ARHGEF19
NextProtQ8IW93 [Medical]
TSGene128272
GENETestsARHGEF19
Target ValidationARHGEF19
Huge Navigator ARHGEF19 [HugePedia]
snp3D : Map Gene to Disease128272
BioCentury BCIQARHGEF19
ClinGenARHGEF19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD128272
Chemical/Pharm GKB GenePA134887028
Clinical trialARHGEF19
Miscellaneous
canSAR (ICR)ARHGEF19 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGEF19
EVEXARHGEF19
GoPubMedARHGEF19
iHOPARHGEF19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jun 18 19:09:54 CEST 2018

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