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ARHGEF25 (Rho guanine nucleotide exchange factor 25)

Identity

Alias_namesRho guanine nucleotide exchange factor (GEF) 25
Alias_symbol (synonym)GEFT
p63RhoGEF
Other alias
HGNC (Hugo) ARHGEF25
LocusID (NCBI) 115557
Atlas_Id 51659
Location 12q13.3  [Link to chromosome band 12q13]
Location_base_pair Starts at 57610180 and ends at 57617245 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
REV3L (6q21) / ARHGEF25 (12q13.3)REV3L 6q21 / ARHGEF25 12q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGEF25   30275
Cards
Entrez_Gene (NCBI)ARHGEF25  115557  Rho guanine nucleotide exchange factor 25
AliasesGEFT; p63RhoGEF
GeneCards (Weizmann)ARHGEF25
Ensembl hg19 (Hinxton)ENSG00000240771 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000240771 [Gene_View]  chr12:57610180-57617245 [Contig_View]  ARHGEF25 [Vega]
ICGC DataPortalENSG00000240771
TCGA cBioPortalARHGEF25
AceView (NCBI)ARHGEF25
Genatlas (Paris)ARHGEF25
WikiGenes115557
SOURCE (Princeton)ARHGEF25
Genetics Home Reference (NIH)ARHGEF25
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGEF25  -     chr12:57610180-57617245 +  12q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGEF25  -     12q13.3   [Description]    (hg19-Feb_2009)
EnsemblARHGEF25 - 12q13.3 [CytoView hg19]  ARHGEF25 - 12q13.3 [CytoView hg38]
Mapping of homologs : NCBIARHGEF25 [Mapview hg19]  ARHGEF25 [Mapview hg38]
OMIM610215   
Gene and transcription
Genbank (Entrez)AB370196 AF487514 AI677902 BC012860 BC018536
RefSeq transcript (Entrez)NM_001111270 NM_001347933 NM_133483 NM_182947
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGEF25
Cluster EST : UnigeneHs.61581 [ NCBI ]
CGAP (NCI)Hs.61581
Alternative Splicing GalleryENSG00000240771
Gene ExpressionARHGEF25 [ NCBI-GEO ]   ARHGEF25 [ EBI - ARRAY_EXPRESS ]   ARHGEF25 [ SEEK ]   ARHGEF25 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGEF25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115557
GTEX Portal (Tissue expression)ARHGEF25
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VW2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VW2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VW2
Splice isoforms : SwissVarQ86VW2
PhosPhoSitePlusQ86VW2
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)ARHGEF25    DH-domain    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)RhoGEF (SM00325)  
Conserved Domain (NCBI)ARHGEF25
DMDM Disease mutations115557
Blocks (Seattle)ARHGEF25
PDB (SRS)2RGN   
PDB (PDBSum)2RGN   
PDB (IMB)2RGN   
PDB (RSDB)2RGN   
Structural Biology KnowledgeBase2RGN   
SCOP (Structural Classification of Proteins)2RGN   
CATH (Classification of proteins structures)2RGN   
SuperfamilyQ86VW2
Human Protein AtlasENSG00000240771
Peptide AtlasQ86VW2
HPRD13573
IPIIPI00472259   IPI00182374   IPI00065255   IPI00892749   
Protein Interaction databases
DIP (DOE-UCLA)Q86VW2
IntAct (EBI)Q86VW2
FunCoupENSG00000240771
BioGRIDARHGEF25
STRING (EMBL)ARHGEF25
ZODIACARHGEF25
Ontologies - Pathways
QuickGOQ86VW2
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  cytosol  plasma membrane  myofibril  sarcomere  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  cytosol  plasma membrane  myofibril  sarcomere  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
NDEx NetworkARHGEF25
Atlas of Cancer Signalling NetworkARHGEF25
Wikipedia pathwaysARHGEF25
Orthology - Evolution
OrthoDB115557
GeneTree (enSembl)ENSG00000240771
Phylogenetic Trees/Animal Genes : TreeFamARHGEF25
HOVERGENQ86VW2
HOGENOMQ86VW2
Homologs : HomoloGeneARHGEF25
Homology/Alignments : Family Browser (UCSC)ARHGEF25
Gene fusions - Rearrangements
Fusion : MitelmanREV3L/ARHGEF25 [6q21/12q13.3]  [t(6;12)(q21;q13)]  
Fusion: TCGAREV3L 6q21 ARHGEF25 12q13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGEF25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGEF25
dbVarARHGEF25
ClinVarARHGEF25
1000_GenomesARHGEF25 
Exome Variant ServerARHGEF25
ExAC (Exome Aggregation Consortium)ARHGEF25 (select the gene name)
Genetic variants : HAPMAP115557
Genomic Variants (DGV)ARHGEF25 [DGVbeta]
DECIPHERARHGEF25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGEF25 
Mutations
ICGC Data PortalARHGEF25 
TCGA Data PortalARHGEF25 
Broad Tumor PortalARHGEF25
OASIS PortalARHGEF25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGEF25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGEF25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGEF25
DgiDB (Drug Gene Interaction Database)ARHGEF25
DoCM (Curated mutations)ARHGEF25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGEF25 (select a term)
intoGenARHGEF25
Cancer3DARHGEF25(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610215   
Orphanet
MedgenARHGEF25
Genetic Testing Registry ARHGEF25
NextProtQ86VW2 [Medical]
TSGene115557
GENETestsARHGEF25
Huge Navigator ARHGEF25 [HugePedia]
snp3D : Map Gene to Disease115557
BioCentury BCIQARHGEF25
ClinGenARHGEF25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115557
Chemical/Pharm GKB GenePA166048997
Clinical trialARHGEF25
Miscellaneous
canSAR (ICR)ARHGEF25 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGEF25
EVEXARHGEF25
GoPubMedARHGEF25
iHOPARHGEF25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:06:38 CEST 2017

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