Identity
HGNC
LOCATION
12q13.3
LOCUSID
ALIAS
GEFT,p63RhoGEF
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 115557
MIM: 610215
HGNC: 30275
Ensembl: ENSG00000240771
Variants:
dbSNP: 115557
ClinVar: 115557
TCGA: ENSG00000240771
COSMIC: ARHGEF25
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000240771 | ENST00000286494 | Q86VW2 |
| ENSG00000240771 | ENST00000333972 | Q86VW2 |
| ENSG00000240771 | ENST00000616622 | Q86VW2 |
| ENSG00000240771 | ENST00000616622 | A0A024RBA8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38225540 | 2024 | Lnc-PSMA8-1 activated by GEFT promotes rhabdomyosarcoma progression via upregulation of mTOR expression by sponging miR-144-3p. | 0 |
| 38225540 | 2024 | Lnc-PSMA8-1 activated by GEFT promotes rhabdomyosarcoma progression via upregulation of mTOR expression by sponging miR-144-3p. | 0 |
| 36977438 | 2023 | Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42. | 0 |
| 36977438 | 2023 | Guanine nucleotide exchange factor T exerts the cancer-promoting function in cholangiocarcinoma by enhancing the Wnt-GSK-3β-β-catenin cascade via regulation of Rac1/Cdc42. | 0 |
| 27833100 | 2016 | Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq. | 10 |
| 27833100 | 2016 | Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq. | 10 |
| 26435194 | 2015 | Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization. | 46 |
| 26435194 | 2015 | Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization. | 46 |
| 24356540 | 2014 | Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients. | 19 |
| 24356540 | 2014 | Increased level of p63RhoGEF and RhoA/Rho kinase activity in hypertensive patients. | 19 |
| 23380069 | 2013 | p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells. | 16 |
| 23884432 | 2013 | Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location. | 7 |
| 23380069 | 2013 | p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells. | 16 |
| 23884432 | 2013 | Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location. | 7 |
| 21832057 | 2011 | Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells. | 13 |
Citation
Dessen P
ARHGEF25 (Rho guanine nucleotide exchange factor 25)
Atlas Genet Cytogenet Oncol Haematol. 2010-09-01
Online version: http://atlasgeneticsoncology.org/gene/51659/arhgef25
