ARHGEF26 (Rho guanine nucleotide exchange factor 26)

2003-05-01  

Identity

HGNC
ARHGEF26
LOCATION
3q25.2
LOCUSID
26084
ALIAS
CSGEF,HMFN1864,SGEF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26084
MIM: 617552
HGNC: 24490
Ensembl: ENSG00000114790

Variants:

dbSNP: 26084
ClinVar: 26084
TCGA: ENSG00000114790
COSMIC: ARHGEF26

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114790ENST00000356448Q96DR7
ENSG00000114790ENST00000356448A0A140VJU4
ENSG00000114790ENST00000465093Q96DR7
ENSG00000114790ENST00000465093A0A140VJU4
ENSG00000114790ENST00000465817Q96DR7
ENSG00000114790ENST00000496710Q96DR7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
287149742017Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.60
223838782012The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity.20
237750762013The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2.17
282026902017A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.10
126976792003Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells.8
267641862016SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.6
228249262012SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression.5
236616352013SGEF enhances EGFR stability through delayed EGFR trafficking from early to late endosomes.5
243994672014Grb2 interacts with SGEF and antagonizes the ability of SGEF to enhance EGF-induced ERK1/2 activation.3
274379492016Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration.1

Citation

Dessen P

ARHGEF26 (Rho guanine nucleotide exchange factor 26)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42280/arhgef26