ARHGEF39 (Rho guanine nucleotide exchange factor 39)

2006-10-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
C9orf100
FUSION GENES

Other Information

Locus ID:

NCBI: 84904
HGNC: 25909
Ensembl: ENSG00000137135

Variants:

dbSNP: 84904
ClinVar: 84904
TCGA: ENSG00000137135
COSMIC: ARHGEF39

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137135ENST00000378387Q8N4T4
ENSG00000137135ENST00000475323Q8N4T4
ENSG00000137135ENST00000490638Q8N4T4

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NRAGE signals death through JNKREACTOMER-HSA-193648
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (12/13) signalling eventsREACTOMER-HSA-416482

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
293829222018ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients.6
223272802012C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma.4
288714492018ARHGEF39 promotes gastric cancer cell proliferation and migration via Akt signaling pathway.3

Citation

Dessen P

ARHGEF39 (Rho guanine nucleotide exchange factor 39)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43176/arhgef39