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ARHGEF40 (Rho guanine nucleotide exchange factor 40)

Identity

Alias_namesRho guanine nucleotide exchange factor (GEF) 40
Alias_symbol (synonym)solo
FLJ10357
Other aliasSOLO
HGNC (Hugo) ARHGEF40
LocusID (NCBI) 55701
Atlas_Id 43264
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 21070260 and ends at 21090247 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IGDCC4 (15q22.31) / ARHGEF40 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)ARHGEF40   25516
Cards
Entrez_Gene (NCBI)ARHGEF40  55701  Rho guanine nucleotide exchange factor 40
AliasesSOLO
GeneCards (Weizmann)ARHGEF40
Ensembl hg19 (Hinxton)ENSG00000165801 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165801 [Gene_View]  chr14:21070260-21090247 [Contig_View]  ARHGEF40 [Vega]
ICGC DataPortalENSG00000165801
TCGA cBioPortalARHGEF40
AceView (NCBI)ARHGEF40
Genatlas (Paris)ARHGEF40
WikiGenes55701
SOURCE (Princeton)ARHGEF40
Genetics Home Reference (NIH)ARHGEF40
Genomic and cartography
GoldenPath hg38 (UCSC)ARHGEF40  -     chr14:21070260-21090247 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ARHGEF40  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblARHGEF40 - 14q11.2 [CytoView hg19]  ARHGEF40 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIARHGEF40 [Mapview hg19]  ARHGEF40 [Mapview hg38]
OMIM610018   
Gene and transcription
Genbank (Entrez)AK001219 AK024463 AK074057 AK126755 AL137291
RefSeq transcript (Entrez)NM_001278529 NM_001278530 NM_018071
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ARHGEF40
Cluster EST : UnigeneHs.35125 [ NCBI ]
CGAP (NCI)Hs.35125
Alternative Splicing GalleryENSG00000165801
Gene ExpressionARHGEF40 [ NCBI-GEO ]   ARHGEF40 [ EBI - ARRAY_EXPRESS ]   ARHGEF40 [ SEEK ]   ARHGEF40 [ MEM ]
Gene Expression Viewer (FireBrowse)ARHGEF40 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55701
GTEX Portal (Tissue expression)ARHGEF40
Human Protein AtlasENSG00000165801-ARHGEF40 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TER5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TER5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TER5
Splice isoforms : SwissVarQ8TER5
PhosPhoSitePlusQ8TER5
Domaine pattern : Prosite (Expaxy)DH_2 (PS50010)    PH_DOMAIN (PS50003)   
Domains : Interpro (EBI)DH-domain    PH_dom-like    PH_domain   
Domain families : Pfam (Sanger)RhoGEF (PF00621)   
Domain families : Pfam (NCBI)pfam00621   
Domain families : Smart (EMBL)PH (SM00233)  
Conserved Domain (NCBI)ARHGEF40
DMDM Disease mutations55701
Blocks (Seattle)ARHGEF40
SuperfamilyQ8TER5
Human Protein Atlas [tissue]ENSG00000165801-ARHGEF40 [tissue]
Peptide AtlasQ8TER5
HPRD13335
IPIIPI00790107   IPI00878303   IPI00878685   IPI00018134   IPI01026152   IPI01017949   IPI01025409   IPI01025773   
Protein Interaction databases
DIP (DOE-UCLA)Q8TER5
IntAct (EBI)Q8TER5
FunCoupENSG00000165801
BioGRIDARHGEF40
STRING (EMBL)ARHGEF40
ZODIACARHGEF40
Ontologies - Pathways
QuickGOQ8TER5
Ontology : AmiGORho guanyl-nucleotide exchange factor activity  cytoplasm  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
Ontology : EGO-EBIRho guanyl-nucleotide exchange factor activity  cytoplasm  regulation of Rho protein signal transduction  positive regulation of GTPase activity  
NDEx NetworkARHGEF40
Atlas of Cancer Signalling NetworkARHGEF40
Wikipedia pathwaysARHGEF40
Orthology - Evolution
OrthoDB55701
GeneTree (enSembl)ENSG00000165801
Phylogenetic Trees/Animal Genes : TreeFamARHGEF40
HOVERGENQ8TER5
HOGENOMQ8TER5
Homologs : HomoloGeneARHGEF40
Homology/Alignments : Family Browser (UCSC)ARHGEF40
Gene fusions - Rearrangements
Tumor Fusion PortalARHGEF40
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerARHGEF40 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ARHGEF40
dbVarARHGEF40
ClinVarARHGEF40
1000_GenomesARHGEF40 
Exome Variant ServerARHGEF40
ExAC (Exome Aggregation Consortium)ENSG00000165801
GNOMAD BrowserENSG00000165801
Genetic variants : HAPMAP55701
Genomic Variants (DGV)ARHGEF40 [DGVbeta]
DECIPHERARHGEF40 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisARHGEF40 
Mutations
ICGC Data PortalARHGEF40 
TCGA Data PortalARHGEF40 
Broad Tumor PortalARHGEF40
OASIS PortalARHGEF40 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICARHGEF40  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDARHGEF40
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ARHGEF40
DgiDB (Drug Gene Interaction Database)ARHGEF40
DoCM (Curated mutations)ARHGEF40 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ARHGEF40 (select a term)
intoGenARHGEF40
Cancer3DARHGEF40(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610018   
Orphanet
DisGeNETARHGEF40
MedgenARHGEF40
Genetic Testing Registry ARHGEF40
NextProtQ8TER5 [Medical]
TSGene55701
GENETestsARHGEF40
Target ValidationARHGEF40
Huge Navigator ARHGEF40 [HugePedia]
snp3D : Map Gene to Disease55701
BioCentury BCIQARHGEF40
ClinGenARHGEF40
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55701
Chemical/Pharm GKB GenePA166048969
Clinical trialARHGEF40
Miscellaneous
canSAR (ICR)ARHGEF40 (select the gene name)
Probes
Litterature
PubMed9 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineARHGEF40
EVEXARHGEF40
GoPubMedARHGEF40
iHOPARHGEF40
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:03:41 CET 2017

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